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| Product | Description | |
|---|---|---|
| MPC-3100 | MPC-3100 is a recently discovered fully synthetic purine-based Hsp90 Inhibitor exhibiting anticancer properties. Group: Biochemicals. Alternative Names: (2S)-1-[4-[2-[6-Amino-8-[(6-bromo-1,3-benzodioxol-5-yl)thio]-9H-purin-9-yl]ethyl]-1-piperidinyl]-2-hydroxy-1-propanone. Grades: Highly Purified. CAS No. 958025-66-6. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| MPC-3100 | MPC-3100 targets the N-terminal ATP-binding site of Hsp90 and blocks the activity of ATPase. In the Her2-luciferase degradation assay, MPC-3100 reduces this client protein of Hsp90 with IC50 value of 60nM. In HCT-116 cell lines, MPC-3100 inhibits cell proliferation with IC50 value of 540 nM. Besides that, MPC-3100 shows a broad spectrum anti-proliferative activity against various cancer cell lines, such as NCI-N87 and DU-145. MPC-3100 also inhibits tumor growth in the NCI-N87 gastric cancer xenograft mode. Moreover, PK studies show that MPC-3100 displays a superior oral PK profile, good overall exposure and a reasonable hepatic clearance rate. Phase I clinical studies demonstrate MPC-3100 is safe and tolerated when administered at doses below 600 mg per day. Synonyms: MPC-3100; MPC 3100; MPC3100. Grades: >98%. CAS No. 958025-66-6. Molecular formula: C22H25BrN6O4S. Mole weight: 549.40. |  |
| 3-? (4-?Morpholinyl) ?propanoic Acid Hydrochloride | 3-? (4-?Morpholinyl) ?propanoic Acid Hydrochloride is a reagent used in the synthesis of an ester prodrug of MPC-3100 (M326505), a recently discovered fully synthetic purine-based Hsp90 Inhibitor exhibiting anticancer properties. Group: Biochemicals. Grades: Highly Purified. CAS No. 6319-95-5. Pack Sizes: 500mg, 1g. Molecular Formula: C7H13NO3; HCl, Molecular Weight: 159.183646. US Biological Life Sciences. | Worldwide |
| MPC-0767 | MPC-0767 is a novel L-alanine ester pro-drug of MPC-3100, designed to have improved aqueous solubility compared to MPC-3100. Synonyms: MPC-0767; MPC 0767; MPC0767. Grades: >98%. CAS No. 1310540-32-9. Molecular formula: C26H36BrN7O9S2. Mole weight: 733.64. | |
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