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| Product | Description | |
|---|---|---|
| MPEP | MPEP is a potent, selective, noncompetitive, orally active and systemically active mGlu5 receptor antagonist, with an IC 50 of 36 nM for completely inhibiting quisqualate-stimulated phosphoinositide (PI) hydrolysis. MPEP has anxiolytic-or antidepressant-like effects [1] [2]. MPEP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 96206-92-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14609A. |  |
| MPEP | MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibiting no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors. Grades: >98%. CAS No. 96206-92-7. Molecular formula: C14H11N. Mole weight: 193.24. |  |
| MPEP hydrochloride | MPEP hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 219911-35-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| MPEP Hydrochloride | MPEP Hydrochloride is a potent, selective, noncompetitive, orally active and systemically active mGlu5 receptor antagonist, with an IC 50 of 36 nM for completely inhibiting quisqualate-stimulated phosphoinositide (PI) hydrolysis. MPEP Hydrochloride has anxiolytic-or antidepressant-like effects [1] [2]. MPEP (Hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 219911-35-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14609. | |
| MPEP Hydrochloride | Potent and selective antagonist for metabotropic glutamate receptor subtype 5 (mGluR5); Systemically active in vivo. Synonyms: 2-Methyl-6-(phenylethynyl)pyridine Hydrochloride. Grades: >98%. CAS No. 219911-35-0. Molecular formula: C14H12ClN. Mole weight: 229.7. | |
| MPEP Hydrochloride (6-Methyl-2- (phenylethynyl) pyridine Hydrochloride) | A non-competitive, highly potent antagonist selective for mGlu5 receptors (IC50 = 36nM). Also a positive allosteric modulator of mGlu4 and weak anatagonist of nMDA receptors. Biologically active admitted systematically. Widely used in assessing the functional roles of mGlu5 receptors in a variety of research areas, such as learning and memory, sleep, neuroprotection, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson's disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 96206-92-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 2-Methyl-6- (phenylethynyl) pyridine, Hydrochloride (MPEP) | A potent, subtype selective mGluR5 antagonist. Group: Biochemicals. Alternative Names: MPEP. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Mmpep | Mmpep. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-[(3-Methoxyphenyl)ethynyl]-6-methylpyridine Hydrochloride; M-MPEP Hydrochloride. Product Category: Heterocyclic Organic Compound. CAS No. 823198-78-3. Molecular formula: C15H14ClNO. Mole weight: 259.73. Purity: 0.96. IUPACName: 2-[2-(3-methoxyphenyl)ethynyl]-6-methylpyridine;hydrochloride. Canonical SMILES: CC1=CC=CC(=N1)C#CC2=CC(=CC=C2)OC.Cl. Product ID: ACM823198783. Alfa Chemistry ISO 9001:2015 Certified. Categories: MMPIP. |  |
| 2-Methyl-6-[ (3-methoxyphenyl) ethynyl]pyridine hydrochloride | 2-Methyl-6-[ (3-methoxyphenyl) ethynyl]pyridine hydrochloride. Group: Biochemicals. Alternative Names: 2-[(3-Methoxyphenyl)ethynyl]-6-methylpyridine hydrochloride; M-MPEP hydrochloride. Grades: Highly Purified. CAS No. 823198-78-3. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C15H14ClNO. US Biological Life Sciences. | Worldwide |
| BMT-145027 | BMT-145027 is a potent mGluR5 PAM without inherent agonist activity with an EC50 of 47 nM. BMT-145027 is a non-MPEP site PAM to demonstrate in vivo efficacy. Synonyms: BMT-145027; BMT 145027; BMT145027; 3-[4-chloro-3-(trifluoromethyl)phenyl]-4-cyclopropyl-6-phenyl-2H-pyrazolo[3,4-b]pyridine-5-carbonitrile. CAS No. 2018282-44-3. Molecular formula: C23H14ClF3N4. Mole weight: 438.83. | |
| Methoxy-PEPy | Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist. Synonyms: methoxy-PEPy; 524924-76-3; 3-methoxy-5-(pyridin-2-ylethynyl)pyridine; MPEPy; 3-methoxy-5-pyridin-2-ylethynylpyridine; 3-methoxy-5-(2-pyridin-2-ylethynyl)pyridine; 0868W4SS6C; 3-methoxy-5-(2-pyridinylethynyl)pyridine; 3-Methoxy-5-(2-(2-pyridinyl)ethynyl)pyridine; Pyridine, 3-methoxy-5-(2-(2-pyridinyl)ethynyl)-; CHEMBL1169452; MLS003509087; UNII-0868W4SS6C; CHEMBL118498; SCHEMBL3959103; VRTFKUFTEWQHDD-UHFFFAOYSA-N; BCP16183; ZVA92476; BDBM50366854; AKOS030526834; CS-3634; NCGC00390782-01; 3-Methoxy-5-pyridin-2-ylethynyl-pyridine; HY-12510; MS-23156; SMR002157261; VU0418523-2; F85101; 3-methoxy-5-[2-(pyridin-2-yl)ethynyl]pyridine; A913545. Grades: >98%. CAS No. 524924-76-3. Molecular formula: C13H10N2O. Mole weight: 210.23. | |
| MTEP | Potent and selective antagonist for mGluR5. 5-fold higher anxiolytic activity than MPEP. Antidepressant. Neuroprotective. Produces anti-parkinsonian-like effects in rats. Group: Biochemicals. Alternative Names: 3-pyridine. Grades: Highly Purified. CAS No. 329205-68-7. Pack Sizes: 5mg, 25mg. Molecular Formula: C11H8N2S. US Biological Life Sciences. | Worldwide |
| Raseglurant | Raseglurant is a negative allosteric modulator of the mGlu5 receptor and derivative of MPEP. It can be used for the treatment of migraine, gastroesophageal reflux disease, and dental anxiety. Phase II clinical trials for all of the aforementioned indications were discontinued due to the observation of possible predictive signs of hepatotoxicity in patients with long-term use. Uses: Migraine, gastroesophageal reflux disease, and dental anxiety. Synonyms: ADX10059; ADX 10059; ADX-10059; 2-[(3-Fluorophenyl)ethynyl]-4,6-dimethyl-3-pyridinamine. Grades: 98%. CAS No. 757950-09-7. Molecular formula: C15H13FN2. Mole weight: 240.28. | |
| VU 0285683 | VU 0285683 is a negative allosteric modulator of mGlu5 receptors with high affinity for the MPEP binding site. VU 0285683 exhibits anxiolytic activity in rodent models of anxiety. Synonyms: VU0285683, VU 0285683, VU-0285683; 3-Fluoro-5-[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]-benzonitrile. Grades: ≥98% by HPLC. CAS No. 327056-22-4. Molecular formula: C14H7FN4O. Mole weight: 266.23. | |
| VU0364289 | VU0364289 is a highly selective mGlu5 positive allosteric modulator (PAM) (binds to the MPEP (HY-14609A) site), with an EC 50 of 1.6 μM. VU0364289 can reverse amphetamine-induced hyperlocomotion in a dose-dependent manner, which can be used for schizophrenia and other psychiatric research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1242443-29-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120727. | |
| VU 29 | VU 29 is a potent positive allosteric potentiator at the rat mGlu5 receptor (EC50 = 9 nM) with selectivity for mGlu5 over mGlu1 and mGlu2 receptors (EC50 = 557 nM and 1.51 μM for mGlu1 and mGlu2, respectively). VU 29 binds to the MPEP allosteric site (Ki app = 244 nM). VU 29 was shown to potentiate both DHPG-induced LTP and threshold θ-burst stimulation (TBS)-induced LTP in rat hippocampal slices. Synonyms: N-(1,3-Diphenyl-1H-pyrazolo-5-yl)-4-nitrobenzamide; DPAP; VU-29; VU 29; VU29; 4-nitro-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide. Grades: ≥99% by HPLC. CAS No. 890764-36-0. Molecular formula: C22H16N4O3. Mole weight: 384.39. | |
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