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| Product | Description | |
|---|---|---|
| MRT-92 | MRT-92 is a potent and selective Smoothened (Smo) receptor inhibitor. MRT-92 displays subnanomolar antagonist activity against Smo in various Hh cell-based assays. MRT-92 inhibits rodent cerebellar granule cell proliferation induced by Hh pathway activation through pharmacologic (half maximal inhibitory concentration [IC50] = 0.4 nM) or genetic manipulation. Synonyms: MRT-92; MRT 92; MRT92. CAS No. 1428315-82-5. Molecular formula: C33H34N4O5. Mole weight: 566.657. |  |
| MRT-92 HCl salt | MRT-92 is a selective Smoothened (Smo) receptor inhibitor. It shows subnanomolar antagonist activity against Smo in various Hh cell-based assays. MRT-92 inhibits rodent cerebellar granule cell proliferation induced by Hh pathway activation through pharmacologic (IC50 value is 0.4 nM) or genetic manipulation. Smo is the target of anticancer drugs, so MRT-92 may be become a drug candidate for treatment of cancer. Uses: Cancer. Synonyms: MRT-92 HCl salt; MRT 92 HCl salt; MRT92 HCl salt; 3, 4, 5-trimethoxy-N- (N- (4-methyl-3- (4-phenethylbenzamido) phenyl) carbamimidoyl) benzamide hydrochloride. Grades: 98%. CAS No. 1428307-52-1. Molecular formula: C33H35ClN4O5. Mole weight: 603.13. | |
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