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| Product | Description | |
|---|---|---|
| MRT67307 | MRT67307 is a dual inhibitor of the IKKε and TBK-1 with IC 50 s of 160 and 19 nM, respectively [1]. MRT67307 also inhibits ULK1 and ULK2 with IC 50 s of 45 and 38 nM, respectively. MRT67307 also blocks autophagy in cells [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1190378-57-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13018. |  |
| MRT67307 | This active molecular is a potent ULK1/2 inhibitor and the IC50 value is 2.9 nM and 1.1 nM. MRT68921 is also a SIK inhibitor. Synonyms: MRT67307; MRT 67307; MRT-67307; N- [3- [ [5-cyclopropyl-2- [3- (morpholin-4-ylmethyl) anilino] pyrimidin-4-yl] amino] propyl] cyclobutanecarboxamide, 1190379-70-4 (HCl). Grades: 98%. CAS No. 1190378-57-4. Molecular formula: C26H36N6O2. Mole weight: 464.61. |  |
| MRT67307 HCl | MRT67307 is a potent and dual IKK? and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. It is an inhibitor for ULK1 and ULK2 with IC50 value of 45 and 38nM, respectively. ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation. Synonyms: MRT 67307 HCl; MRT-67307 HCl; MRT67307 HCl. Grades: 99.80 %. Molecular formula: C26H36N6O2· xHCl. Mole weight: 464.6 (free-base). | |
| MRT67307 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| IKK epsilon/TBK1 Inhibitor II, MRT67307 (TANK Binding Kinase 1/IKKinducible Inhibitor II, N- (3- (5-Cyclopropyl -2- (3- (morpholino methyl ) phenylamino) pyrimidin-4-ylamino) propyl ) cyclobutane carboxamide) | A cell-permeable BX795 analog that acts as a potent, ATP-competitive, and reversible dual kinase inhibitor of TBK1/IKK epsilon (IC50 = 19 and 160nM, respectively) with excellent selectivity over IKKalpha and IKKbeta (IC50 > 10uM). Interacts with the TBK1 kinase dimer interface and stabilizes the inactive DFG-out conformation. Also blocks the activity of MARK (microtubule- associated protein (MAP)-microtubule affinity regulating kinase) 1, 2, 3, and 4 (IC50 = 27, 52, 36, and 41nM, respectively), SIK2 (IC50 = 67nM) and Aurora B, JAK2, and MLK1,3 (> than 90% inhibition at 1uM) in a 108-kinase panel. Increases TNF-alpha-stimulated NF-kB-dependent gene transcription in wild-type macrophages and enhances CREB-dependent gene transcription by promoting dephosphorylation of CREB-regulated transcription coactivator (CRTC3). Shown to aid TLR-stimulated production of anti-Inflammatory cytokines in macrophages while suppressing the secretion of pro-inflammatory cytokines. In response to pro-inflammÂ… Group: Biochemicals. Grades: Highly Purified. CAS No. 495-85-2. Pack Sizes: 5mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. |  Worldwide |
| MRT 67307 dihydrochloride | MRT 67307 is a salt inducible kinase (SIK) inhibitor (IC50 values are 67, 250 and 430 nM for SIK2, SIK1 and SIK3 respectively). MRT67307 potently inhibits ULK1 and ULK2 in vitro and block autophagy in cells. ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation. Synonyms: MRT 67307 dihydrochloride; MRT67307 dihydrochloride; MRT-67307 dihydrochloride; N- [3- [ [5-Cyclopropyl-2- [ [3- (4-morpholinylmethyl) phenyl] amino] -4-pyrimidinyl] amino] propyl] cyclobutanecarboxamide dihydrochloride. Grades: ≥98% by HPLC. Molecular formula: C26H36N6O2.2HCl. Mole weight: 537.52. | |
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