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| Product | Description | |
|---|---|---|
| MRX-2843 | MRX-2843, also known as UNC2371, is a potent and orally active MERTK and FLT3 inhibitor. MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia. MRX-2843 in combination with an irreversible EGFR TKI as a novel strategy for treatment of patients with wtEGFR NSCLC. MRX-2843 treatment induces apoptosis and inhibits colony formation in AML cell lines and primary patient samples expressing MERTK and/or FLT3-ITD, with a wide therapeutic window compared with that of normal human cord blood cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MRX-2843; MRX 2843; MRX2843; UNC2371; UNC-2371; UNC 2371; UNC2371A; UNC-2371A; UNC 2371A. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1429882-07-4. Molecular formula: C29H40N6O. Mole weight: 488.68. Purity: >95%. IUPACName: (1r,4r)-4-(2-((2-cyclopropylethyl)amino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol. Canonical SMILES: O[C@H]1CC[C@H](N2C=C(C3=CC=C(CN4CCN(C)CC4)C=C3)C5=CN=C(NCCC6CC6)N=C52)CC1. Product ID: ACM1429882074. Alfa Chemistry ISO 9001:2015 Certified. |  |
| MRX-2843 | MRX-2843 is a dual inhibitor of MerTK and FLT3 with IC50 values of 1.3 and 1 nM, respectively. It induces apoptosis and inhibits colony formation in AML cell lines and other tumor cells expressing MERTK and/or FLT3-ITD. Treatment with MRX-2843 significantly prolonged survival of AML mouse models. Synonyms: 4-[2-(2-cyclopropylethylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol. Grades: ≥95%. CAS No. 1429882-07-4. Molecular formula: C29H40N6O. Mole weight: 488.68. |  |
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