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| Product | Description | |
|---|---|---|
| MS023 | MS023 is a Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. MS023 displayed high potency for type I PRMTs including PRMT1, -3, -4, -6, and -8 but was completely inactive against type II and type III PRMTs, protein lysine methyltransferases and DNA methyltransferases. Synonyms: MS023; MS-023; MS 023. Grades: 98%. CAS No. 1831110-54-3. Molecular formula: C17H25N3O. Mole weight: 287.41. |  |
| MS023 dihydrochloride | MS023 dihydrochloride is a potent, selective and cell-active human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively. Synonyms: N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine dihydrochloride; N-{[4-(4-Isopropoxyphenyl)-1H-pyrrol-3-yl]methyl}-N-methyl-1,2-ethanediamine dihydrochloride; 1,2-Ethanediamine, N1-methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-, hydrochloride (1:2). Grades: ≥95%. CAS No. 1992047-64-9. Molecular formula: C17H27Cl2N3O. Mole weight: 360.32. | |
| MS023 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| MS023 hydrochloride | Cas No. 2108631-19-0. | |
| MS 023 dihydrochloride | MS 023 is a potent and selective type I PRMT inhibitor (IC50= 8, 8, 30, 83 and 119 nM for PRMT6, PRMT8, PRMT1, PRMT4 and PRMT3, respectively). Importantly, MS023 does not inhibit any type II PRMTs (PRMT5 and 9) and type III PRMT (PRMT7) at concentrations up to 10 μM. MS023 displays high potency for type I PRMTs including PRMT1, -3, -4, -6, and -8 but is completely inactive against type II and type III PRMTs, protein lysine methyltransferases and DNA methyltransferases. Synonyms: MS 023 dihydrochloride; MS023 dihydrochloride; MS-023 dihydrochloride; N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine dihydrochloride. Grades: ≥98% by HPLC. Molecular formula: C17H25N3O.2HCl. Mole weight: 360.32. | |
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