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| Product | Description | |
|---|---|---|
| MTEP hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| MTEP hydrochloride | Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. MTEP is a negative allosteric modulator of the mGlu5a receptor subtype (Ki = 42 nM; IC50=110 nM). MTEP at 0.3 mg/kg produces antidepressant effects in several rodent models of depression. It also demonstrates neuroprotective potential by preventing excitotoxic neuronal damage when administered through either intrahippocampal or intraperitoneal injection. Additionally, MTEP demonstrates an anxiolytic-like phenotype in rodent models similar to that of benzodiazepines while lacking undesirable sedative and addictive effects. Synonyms: 3-((2-Methyl-1,3-thiazol-4-yl)ethyn-yl)pyridine hydrochloride; MTEP. Grades: >98%. CAS No. 1186195-60-7. Molecular formula: C11H9ClN2S. Mole weight: 236.72. |  |
| MTEP hydrochloride | MTEP hydrochloride is a potent, non-competitive and highly selective mGluR5 antagonist, with an IC 50 of 5 nM and a K i of 16 nM. MTEP hydrochloride shows antidepressant and anxiolytic-like effects. MTEP hydrochloride can be used for Parkinson's disease research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1186195-60-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13206. |  |
| MTEP Hydrochloride | MTEP Hydrochloride. Group: Biochemicals. Alternative Names: 3-[ (2-Methyl-4-thiazolyl) ethynyl]pyridine; 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine Hydrochloride. Grades: Highly Purified. CAS No. 329205-68-7. Pack Sizes: 10mg. Molecular Formula: C11H9ClN2S, Molecular Weight: 236.72. US Biological Life Sciences. |  Worldwide |
| MTEP Hydrochloride (3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine Hydrochloride) | A non-competitive, potent antagonist highly selective for mGlu5 receptors (IC50 = 5nM). Biologically active admitted orally or systematically. Widely used in assessing the functional roles of mGlu5 receptors in a variety of research areas, such as neuroprotection, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson's disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 1186195-60-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
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