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| Product | Description | |
|---|---|---|
| mycothiol S-conjugate amidase | The enzyme that is found in actinomycetes is involved in the detoxification of oxidizing agents and electrophilic antibiotics. The enzyme has low activity with 1-O-(2-acetamido-2-deoxy-α-D-glucopyranosyl)-1D-myo-inositol as substrate (cf. EC 3.5.1.103, N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-α-D-glucopyranoside deacetylase). Group: Enzymes. Synonyms: MCA. Enzyme Commission Number: EC 3.5.1.115. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4395; mycothiol S-conjugate amidase; EC 3.5.1.115; MCA. Cat No: EXWM-4395. |  |
| mycothiol synthase | This enzyme catalyses the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes, including Mycobacterium. The enzyme is a member of a large family of GCN5-related N-acetyltransferases (GNATs). The enzyme has been purified from Mycobacterium tuberculosis H37Rv. Acetyl-CoA is the preferred CoA thioester but propionyl-CoA is also a substrate. Group: Enzymes. Synonyms: MshD. Enzyme Commission Number: EC 2.3.1.189. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2131; mycothiol synthase; EC 2.3.1.189; MshD. Cat No: EXWM-2131. | |
| arsenate-mycothiol transferase | Reduction of arsenate is part of a defence mechanism of the cell against toxic arsenate. The product arseno-mycothiol is reduced by EC 1.20.4.3 (mycoredoxin) to arsenite and mycothiol-mycoredoxin disulfide. Finally, a second mycothiol recycles mycoredoxin and forms mycothione. Group: Enzymes. Synonyms: ArsC1; ArsC2; mycothiol:arsenate transferase. Enzyme Commission Number: EC 2.8.4.2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3428; arsenate-mycothiol transferase; EC 2.8.4.2; ArsC1; ArsC2; mycothiol:arsenate transferase. Cat No: EXWM-3428. | |
| S-(hydroxymethyl)mycothiol dehydrogenase | S-hydroxymethylmycothiol is believed to form spontaneously from formaldehyde and mycothiol. This enzyme oxidizes the product of this spontaneous reaction to S-formylmycothiol, in a reaction that is analogous to EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase. Group: Enzymes. Synonyms: NAD/factor-dependent formaldehyde dehydrogenase; mycothiol-dependent formaldehyde dehydrogenase. Enzyme Commission Number: EC 1.1.1.306. CAS No. 192140-85-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0217; S-(hydroxymethyl)mycothiol dehydrogenase; EC 1.1.1.306; 192140-85-5; NAD/factor-dependent formaldehyde dehydrogenase; mycothiol-dependent formaldehyde dehydrogenase. Cat No: EXWM-0217. | |
| D-inositol-3-phosphate glycosyltransferase | The enzyme, which belongs to the GT-B fold superfamily, catalyses the first dedicated reaction in the biosynthesis of mycothiol. The substrate was initially believed to be inositol, but eventually shown to be D-myo-inositol 3-phosphate. A substantial conformational change occurs upon UDP binding, which generates the binding site for D-myo-inositol 3-phosphate. Group: Enzymes. Synonyms: mycothiol glycosyltransferases; MshA; UDP-N-acetyl-D-glucosamine:1D-myo-inositol 3-phosphate α-D-glycosyltransferase. Enzyme Commission Number: EC 2.4.1.250. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2480; D-inositol-3-phosphate glycosyltransferase; EC 2.4.1.250; mycothiol glycosyltransferases; MshA; UDP-N-acetyl-D-glucosamine:1D-myo-inositol 3-phosphate α-D-glycosyltransferase. Cat No: EXWM-2480. | |
| L-cysteine:1D-myo-inositol 2-amino-2-deoxy-α-D-glucopyranoside ligase | This enzyme is a key enzyme in the biosynthesis of mycothiol, a small molecular weight thiol found in Mycobacteria spp. and other actinomycetes. Mycothiol plays a fundamental role in these organisms by helping to provide protection from the effects of reactive oxygen species and electrophiles, including many antibiotics. The enzyme may represent a novel target for new classes of antituberculars. Group: Enzymes. Synonyms: MshC; MshC ligase; Cys:GlcN-Ins ligase; mycothiol ligase. Enzyme Commission Number: EC 6.3.1.13. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5716; L-cysteine:1D-myo-inositol 2-amino-2-deoxy-α-D-glucopyranoside ligase; EC 6.3.1.13; MshC; MshC ligase; Cys:GlcN-Ins ligase; mycothiol ligase. Cat No: EXWM-5716. | |
| mycoredoxin | Reduction of arsenate is part of a defense mechanism of the cell against toxic arsenate. The substrate arseno-mycothiol is formed by EC 2.8.4.2 (arsenate:mycothiol transferase). A second mycothiol recycles mycoredoxin and forms mycothione. Group: Enzymes. Synonyms: Mrx1; MrxI. Enzyme Commission Number: EC 1.20.4.3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1242; mycoredoxin; EC 1.20.4.3; Mrx1; MrxI. Cat No: EXWM-1242. | |
| mycothione reductase | Contains FAD. No activity with glutathione, trypanothione or coenzyme A as substrate. Group: Enzymes. Synonyms: mycothiol-disulfide reductase. Enzyme Commission Number: EC 1.8.1.15. CAS No. 252212-92-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1641; mycothione reductase; EC 1.8.1.15; 252212-92-3; mycothiol-disulfide reductase. Cat No: EXWM-1641. | |
| N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-α-D-glucopyranoside deacetylase | This enzyme is considered the key enzyme and rate limiting step in the mycothiol biosynthesis pathway. In addition to acetylase activity, the enzyme possesses weak activity of EC 3.5.1.115, mycothiol S-conjugate amidase, and shares sequence similarity with that enzyme. The enzyme requires a divalent transition metal ion for activity, believed to be Zn2+. Group: Enzymes. Synonyms: MshB. Enzyme Commission Number: EC 3.5.1.103. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4382; N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-α-D-glucopyranoside deacetylase; EC 3.5.1.103; MshB. Cat No: EXWM-4382. | |
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