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| Product | Description | |
|---|---|---|
| Mycothiol disulfide - Stabilised with trifluoroacetic acid ammonium salt | Mycothiol Disulfide is an indispensable biomedical compound,diligently aiding in studying an extensive array of tenacious bacterial infections. Its unparalleled prowess lies in its capacity to effectively obstruct bacterial proliferation while effortlessly surmounting drug resistance mechanisms. Elevating its impact further is a fortified formulation merged with the trifluoroacetic acid ammonium salt embodies unfaltering stability and amplified effectiveness. Synonyms: 1-O-[2-[[(2R)-2-(Acetylamino)-3-mercapto-1-oxopropyl]amino]-2-deoxy-α-D-glucopyranosyl]-D-myo-inositol disulfide; AcCys-GlcN-Ins. CAS No. 192126-76-4. Molecular formula: C34H58N4O24S2. Mole weight: 970.97. |  |
| mycothiol S-conjugate amidase | The enzyme that is found in actinomycetes is involved in the detoxification of oxidizing agents and electrophilic antibiotics. The enzyme has low activity with 1-O-(2-acetamido-2-deoxy-α-D-glucopyranosyl)-1D-myo-inositol as substrate (cf. EC 3.5.1.103, N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-α-D-glucopyranoside deacetylase). Group: Enzymes. Synonyms: MCA. Enzyme Commission Number: EC 3.5.1.115. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4395; mycothiol S-conjugate amidase; EC 3.5.1.115; MCA. Cat No: EXWM-4395. |  |
| mycothiol synthase | This enzyme catalyses the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes, including Mycobacterium. The enzyme is a member of a large family of GCN5-related N-acetyltransferases (GNATs). The enzyme has been purified from Mycobacterium tuberculosis H37Rv. Acetyl-CoA is the preferred CoA thioester but propionyl-CoA is also a substrate. Group: Enzymes. Synonyms: MshD. Enzyme Commission Number: EC 2.3.1.189. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2131; mycothiol synthase; EC 2.3.1.189; MshD. Cat No: EXWM-2131. | |
| arsenate-mycothiol transferase | Reduction of arsenate is part of a defence mechanism of the cell against toxic arsenate. The product arseno-mycothiol is reduced by EC 1.20.4.3 (mycoredoxin) to arsenite and mycothiol-mycoredoxin disulfide. Finally, a second mycothiol recycles mycoredoxin and forms mycothione. Group: Enzymes. Synonyms: ArsC1; ArsC2; mycothiol:arsenate transferase. Enzyme Commission Number: EC 2.8.4.2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3428; arsenate-mycothiol transferase; EC 2.8.4.2; ArsC1; ArsC2; mycothiol:arsenate transferase. Cat No: EXWM-3428. | |
| S-(hydroxymethyl)mycothiol dehydrogenase | S-hydroxymethylmycothiol is believed to form spontaneously from formaldehyde and mycothiol. This enzyme oxidizes the product of this spontaneous reaction to S-formylmycothiol, in a reaction that is analogous to EC 1.1.1.284, S-(hydroxymethyl)glutathione dehydrogenase. Group: Enzymes. Synonyms: NAD/factor-dependent formaldehyde dehydrogenase; mycothiol-dependent formaldehyde dehydrogenase. Enzyme Commission Number: EC 1.1.1.306. CAS No. 192140-85-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0217; S-(hydroxymethyl)mycothiol dehydrogenase; EC 1.1.1.306; 192140-85-5; NAD/factor-dependent formaldehyde dehydrogenase; mycothiol-dependent formaldehyde dehydrogenase. Cat No: EXWM-0217. | |
| D-inositol-3-phosphate glycosyltransferase | The enzyme, which belongs to the GT-B fold superfamily, catalyses the first dedicated reaction in the biosynthesis of mycothiol. The substrate was initially believed to be inositol, but eventually shown to be D-myo-inositol 3-phosphate. A substantial conformational change occurs upon UDP binding, which generates the binding site for D-myo-inositol 3-phosphate. Group: Enzymes. Synonyms: mycothiol glycosyltransferases; MshA; UDP-N-acetyl-D-glucosamine:1D-myo-inositol 3-phosphate α-D-glycosyltransferase. Enzyme Commission Number: EC 2.4.1.250. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2480; D-inositol-3-phosphate glycosyltransferase; EC 2.4.1.250; mycothiol glycosyltransferases; MshA; UDP-N-acetyl-D-glucosamine:1D-myo-inositol 3-phosphate α-D-glycosyltransferase. Cat No: EXWM-2480. | |
| L-cysteine:1D-myo-inositol 2-amino-2-deoxy-α-D-glucopyranoside ligase | This enzyme is a key enzyme in the biosynthesis of mycothiol, a small molecular weight thiol found in Mycobacteria spp. and other actinomycetes. Mycothiol plays a fundamental role in these organisms by helping to provide protection from the effects of reactive oxygen species and electrophiles, including many antibiotics. The enzyme may represent a novel target for new classes of antituberculars. Group: Enzymes. Synonyms: MshC; MshC ligase; Cys:GlcN-Ins ligase; mycothiol ligase. Enzyme Commission Number: EC 6.3.1.13. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5716; L-cysteine:1D-myo-inositol 2-amino-2-deoxy-α-D-glucopyranoside ligase; EC 6.3.1.13; MshC; MshC ligase; Cys:GlcN-Ins ligase; mycothiol ligase. Cat No: EXWM-5716. | |
| mycoredoxin | Reduction of arsenate is part of a defense mechanism of the cell against toxic arsenate. The substrate arseno-mycothiol is formed by EC 2.8.4.2 (arsenate:mycothiol transferase). A second mycothiol recycles mycoredoxin and forms mycothione. Group: Enzymes. Synonyms: Mrx1; MrxI. Enzyme Commission Number: EC 1.20.4.3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1242; mycoredoxin; EC 1.20.4.3; Mrx1; MrxI. Cat No: EXWM-1242. | |
| Mycothione | Mycothione is an efficacious antioxidant and detoxifying compound aiding in the research of an extensive array of drug-resistant microbial afflictions, including the notorious tuberculosis. Synonyms: Mycothione; MSSM; (2R, 2'R) -3, 3'-disulfanediylbis{2- (acetylamino) -N- [ (2R, 3R, 4R, 5S, 6R) -4, 5-dihydroxy-6- (hydroxymethyl) -2-{ [ (1S, 2R, 3R, 4S, 5S, 6R) -2, 3, 4, 5, 6-pentahydroxycyclohexyl] oxy}tetrahydro-2H-pyran-3-yl] propanamide}; Mycothiol disulfide; CHEBI:16086; Q27098374; (2R)-2-acetamido-3-[[(2R)-2-acetamido-3-[[(2R,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[(2R,3R,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxyoxan-3-yl]amino]-3-oxopropyl]disulfanyl]-N-[(2R,3R,4R,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[(2R,3R,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxyoxan-3-yl]propanamide; 2-acetylamino-3-[2-acetylamino-2-[[4,5-dihydroxy-6-(hydroxymethyl)-2-(2,3,4,5,6-pentahydroxycyclohexoxy)-tetrahydropyran-3-yl]carbamoyl]ethyl]disulfanyl-N-[4,5-dihydroxy-6-(hydroxymethyl)-2-(2,3,4,5,6-pentahydroxycyclohexoxy)-tetrahydropyran-3-yl]-propanamide. Molecular formula: C34H58N4O24S2. Mole weight: 970.97. | |
| mycothione reductase | Contains FAD. No activity with glutathione, trypanothione or coenzyme A as substrate. Group: Enzymes. Synonyms: mycothiol-disulfide reductase. Enzyme Commission Number: EC 1.8.1.15. CAS No. 252212-92-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1641; mycothione reductase; EC 1.8.1.15; 252212-92-3; mycothiol-disulfide reductase. Cat No: EXWM-1641. | |
| N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-α-D-glucopyranoside deacetylase | This enzyme is considered the key enzyme and rate limiting step in the mycothiol biosynthesis pathway. In addition to acetylase activity, the enzyme possesses weak activity of EC 3.5.1.115, mycothiol S-conjugate amidase, and shares sequence similarity with that enzyme. The enzyme requires a divalent transition metal ion for activity, believed to be Zn2+. Group: Enzymes. Synonyms: MshB. Enzyme Commission Number: EC 3.5.1.103. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4382; N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-α-D-glucopyranoside deacetylase; EC 3.5.1.103; MshB. Cat No: EXWM-4382. | |
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