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N-Methyl-L-alanine is a reactant used in the preparation of site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity. Synonyms: N-Me-L-Ala-OH HCl; N-Methyl-L-alanine; (2S)-2-(methylamino)propanoic acid. Grade: ≥ 98% (TLC). CAS No. 3913-67-5. Molecular formula: C4H9NO2·HCl. Mole weight: 139.62.
N-Methyl-L-alanine hydrochloride 98+% (TLC)
N-Methyl-L-alanine hydrochloride 98+% (TLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g, 100g. US Biological Life Sciences.
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N-Methyl-L-Alanine methyl ester hydrochloride
N-Methyl-L-Alanine methyl ester hydrochloride. Group: Biochemicals. Alternative Names: N-Me-L-Ala-OMe·HCl. Grades: Highly Purified. CAS No. 35023-55-3. Pack Sizes: 500mg, 1g, 2g, 5g. US Biological Life Sciences.
N-Methyl-L-alanine tert-butyl ester hydrochloride 98+% (NMR). Group: Biochemicals. Grades: Reagent Grade. CAS No. 103614-40-0. Pack Sizes: 250mg, 1g, 5g, 10g. US Biological Life Sciences.
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Boc-N-methyl-L-alanine
Boc-N-methyl-L-alanine. Group: Biochemicals. Alternative Names: N-[ (1, 1-Dimethylethoxy) carbonyl]-N-methyl-L-alanine; (S) -2-[ (tert-Butoxycarbonyl) (methyl) amino]propanoic acid; N-Methyl-N- (tert-butyloxycarbonyl) alanine. Grades: Highly Purified. CAS No. 16948-16-6. Pack Sizes: 10g, 25g, 50g, 100g, 250g. Molecular Formula: C9H17NO4. US Biological Life Sciences.
Worldwide
Native Bacillus sp. Sarcosine Oxidase
Sarcosine oxidase is an enzyme (EC 1.5.3.1) that catalyzes the oxidative demethylation of sarcosine to yield glycine, H2O2, 5,10-CH2-tetrahydrofolate in a reaction requiring H4-tetrahydrofolate and oxygen. Corynebacterial sarcosine oxidase is a heterotetramer and is produced as an inducible enzyme when Corynebacterium sp.is grown with sarcosine as source of carbon and energy. Monomeric sarcosine oxidase (msox) is a flavoenzyme that catalyzes the oxidative demethylation of sarcosine (n-methylglycine) to yield glycine, formaldehyde, and hydrogen peroxide. monomeric sarcosine oxidase can oxidize other secondary amino acids such as n-methyl-l-alanine, n-ethylglycine, and l-proline. Applications: Sarcosine oxidase has been used in a study as part of a multienzyme cascade, that when immobilized constructed amperometric biosensors. sarcosine oxidase has also been used in a study to investigate oxidation of amines by flavoproteins. Group: Enzymes. Synonyms: Sarcosine oxidase; EC 1.5.3.1; 9029-22-5; sarcosine:oxygen oxidoreductase (demethylating). Enzyme Commission Number: EC 1.5.3.1. CAS No. 9029-22-5. SAO. Activity: 25-50 units/mg solid. Storage: -20°C. Form: lyophilized powder; No stabilizers added. Source: Bacillus sp. Sarcosine oxidase; EC 1.5.3.1; 9029-22-5; sarcosine:oxygen oxidoreductase (demethylating). Cat No: NATE-0664.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is N-methyl-L-alanine:NADP+ oxidoreductase (demethylating, deaminating). Group: Enzymes. Enzyme Commission Number: EC 1.4.1.17. CAS No. 56379-51-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1450; N-methylalanine dehydrogenase; EC 1.4.1.17; 56379-51-2. Cat No: EXWM-1450.
Mertansine
Mertansine, the cytotoxic component in antibody-drug conjugates, is attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker or SMCC (4-(3-mercapto-2,5-dioxo-1 pyrrolidinylmethyl)-cylohexanecarboxylic acid) linkerto create an antibody-drug conjugate. It derives from a maytansine. Synonyms: (14S,16S,33S,2R,4R,10E,12Z,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-(3-mercaptopropanoyl)-N-methyl-L-alaninate; N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine; DM 1; Maytansinoid DM 1; N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine; DM-1; DM1; DM1 Compound; DM1 [Maytansinoid]. Grade: ≥95%. CAS No. 139504-50-0. Molecular formula: C35H48ClN3O10S. Mole weight: 738.29.
N-Me-L-Ala-maytansinol
N-Me-L-Ala-maytansinol is a hydrophobic, cell permeable payload used in the preparation of antibody-drug conjugate (ADC). Synonyms: AP3 Intermidate 1; Maytansinol 3-(S)-α-N-methylaminopropionate; Maytansine, N2'-deacetyl-; (1S,2R,3S,5S,6S,16Z,18Z,20R,21S)-11-Chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10(26),11,13,16,18-pentaen-6-yl N-methyl-L-alaninate; Maytansinol-Ala. Grade: 90%. CAS No. 77668-69-0. Molecular formula: C32H44ClN3O9. Mole weight: 650.17.
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