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| Product | Description | |
|---|---|---|
| 5'-DMT-2'-O-TBDMS-N1-Methyl-PseudoUridine-CE-Phosphoramidite | It is a modified ribonucleoside analogue suitable for incorporation into small interfering RNA (siRNA) to enhance RNA stability in biological applications such as gene silencing. Synonyms: 5'-Dimethoxytrityl-1-methyl-pseudouridine, 2'-O-TBDMS-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 5-[5-O-[bis(4-methoxyphenyl)?phenylmethyl]?-3-O-[[bis(1-methylethyl)?amino]?(2-cyanoethoxy)?phosphino]?-2-O-[(1,?1-dimethylethyl)?dimethylsilyl]?-β-D-ribofuranosyl]?-1-methyl-2,?4(1H,?3H)?-pyrimidinedione; 2'-O-TBDMS-N1-Me-Pseudouridine CEP; 5'-O-DMTr-2'-O-TBDMS-N1-methylpseudouridine 3'-(cyanoethyl-N,N-diisopropyl)phosphoramidite; 5'-O-DMT-2'-O-TBDMS-N1-Me-pU Phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(t-butyldimethylsilyl)-N1-methyl-Pseudouridine-3'-cyanoethyl Phosphoramidite. Grade: ≥98%. CAS No. 875302-45-7. Molecular formula: C46H63N4O9PSi. Mole weight: 875.07. |  |
| 1-MethylpseudoUridine | N1-methyl-pseudoUridine (1-Methylpseudouridine), a methylpseudoUridine, outperforms 5 mC and 5 mC/N1-methyl-pseudoUridine in translation. N1-methyl-pseudoUridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density. Synonyms: N1-Methylpseudouridine; 2,4(1H,3H)-Pyrimidinedione, 1-methyl-5-b-D-ribofuranosyl-; (-)-1-Methyl-5-(β-D-ribofuranosyl)-2,4(1H,3H)-pyrimidinedione; Antibiotic U-50228; U-50228; 1-N-Me-pseudouridine; (1S)-1,4-anhydro-1-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-D-ribitol; Uracil, 1-methyl-5-b-D-ribofuranosyl-. Grade: ≥95%. CAS No. 13860-38-3. Molecular formula: C10H14N2O6. Mole weight: 258.23. | |
| ALC-0315 LNP-Cap 1 EGFP mRNA (m1Ψ) | This product is a LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating EGFP mRNA. EGFP mRNA, a common fluorescence reporter, translates into enhanced green fluorescent protein, which exhibits an excitation wavelength of 488 nm and emission at 507 nm. The loaded EGFP mRNA is capped with the CAP 1 structure and modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. |  |
| ALC-0315 LNP-Cap 1 Fluc mRNA (m1Ψ) | This product is a LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. The loaded Firefly Luciferase mRNA is capped with the CAP 1 structure and modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| ALC-0315 LNP-EGFP mRNA (m1Ψ) | This product is a LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating EGFP mRNA. EGFP mRNA, a common fluorescence reporter, translates into enhanced green fluorescent protein, which exhibits an excitation wavelength of 488 nm and emission at 507 nm. The loaded EGFP mRNA is modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| ALC-0315 LNP-Fluc mRNA (m1Ψ) | This product is a LNP prepared with ionizable lipid (ALC-0315), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. The loaded Firefly Luciferase mRNA is modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| CD34+ Cells Targeted SM102 LNP-EGFP mRNA (m1Ψ) | This product is a LNP prepared from SM102 as the ionizable lipid and modified with CD34 antibody. It's specifically designed for targeted delivery of EGFP mRNA to CD34 positive cells. EGFP mRNA, a common fluorescence reporter, translates into enhanced green fluorescent protein, which exhibits an excitation wavelength of 488 nm and emission at 507 nm. The loaded EGFP mRNA is modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| DLin-MC3-DMA LNP-Cap 1 EGFP mRNA (m1Ψ) | This product is a LNP prepared with ionizable lipid (DLin-MC3-DMA), helper lipid, cholesterol and PEGylated lipid, encapsulating EGFP mRNA. EGFP mRNA, a common fluorescence reporter, translates into enhanced green fluorescent protein, which exhibits an excitation wavelength of 488 nm and emission at 507 nm. The loaded EGFP mRNA is capped with the CAP 1 structure and modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| DLin-MC3-DMA LNP-Cap 1 Fluc mRNA (m1Ψ) | This product is a LNP prepared with ionizable lipid (DLin-MC3-DMA), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. The loaded Firefly Luciferase mRNA is capped with the CAP 1 structure and modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| DLin-MC3-DMA LNP-Cap 1 OVA mRNA (m1Ψ) | This product is a LNP prepared with ionizable lipid (DLin-MC3-DMA), helper lipid, cholesterol and PEGylated lipid, encapsulating OVA mRNA. OVA(ovalbumin) is the predominant glycoprotein in egg whites and is known for its immunogenic properties, making it an ideal model antigen for studying immune responses. The loaded OVA mRNA is capped with the CAP 1 structure and modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| DLin-MC3-DMA LNP-EGFP mRNA (m1Ψ) | This product is a LNP prepared with ionizable lipid (DLin-MC3-DMA), helper lipid, cholesterol and PEGylated lipid, encapsulating EGFP mRNA. EGFP mRNA, a common fluorescence reporter, translates into enhanced green fluorescent protein, which exhibits an excitation wavelength of 488 nm and emission at 507 nm. The loaded EGFP mRNA is modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| Liver Targeted SM102 LNP-EGFP mRNA (m1Ψ) | This product is a LNP prepared from SM102 as the ionizable lipid and modified with tri-GalNac ligand. It's specifically designed for targeted delivery of EGFP mRNA to hepatocyte. EGFP mRNA, a common fluorescence reporter, translates into enhanced green fluorescent protein, which exhibits an excitation wavelength of 488 nm and emission at 507 nm. The loaded EGFP mRNA is modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| Liver Targeted SM102 LNP-Fluc mRNA (m1Ψ) | This product is a multi-component LNP prepared from SM102 as the ionizable lipid and DODAP as cationic lipid. It's specifically designed for targeted delivery of Firefly Luciferase mRNA to liver. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. The loaded Firefly Luciferase mRNA is modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| LP-01 LNP-Cap 1 EGFP mRNA (m1Ψ) | This product is a LNP prepared with ionizable lipid (LP-01), helper lipid, cholesterol and PEGylated lipid, encapsulating EGFP mRNA. EGFP mRNA, a common fluorescence reporter, translates into enhanced green fluorescent protein, which exhibits an excitation wavelength of 488 nm and emission at 507 nm. The loaded EGFP mRNA is capped with the CAP 1 structure and modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| LP-01 LNP-Cap 1 Fluc mRNA (m1Ψ) | This product is a LNP prepared with ionizable lipid (LP-01), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. The loaded Firefly Luciferase mRNA is capped with the CAP 1 structure and modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| LP-01 LNP-EGFP mRNA (m1Ψ) | This product is a LNP prepared with ionizable lipid (LP-01), helper lipid, cholesterol and PEGylated lipid, encapsulating EGFP mRNA. EGFP mRNA, a common fluorescence reporter, translates into enhanced green fluorescent protein, which exhibits an excitation wavelength of 488 nm and emission at 507 nm. The loaded EGFP mRNA is modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| LP-01 LNP-Fluc mRNA (m1Ψ) | This product is a LNP prepared with ionizable lipid (LP-01), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. The loaded Firefly Luciferase mRNA is modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| Lung Targeted ALC-0315 LNP-Fluc mRNA (m1Ψ) | This product is a multi-component LNP prepared from ALC-0315 as the ionizable lipid. It's specifically designed for targeted delivery of Firefly Luciferase mRNA to lung. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. The loaded Firefly Luciferase mRNA is modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| Lung Targeted SM102 LNP-Fluc mRNA (m1Ψ) | This product is a LNP prepared from SM102 as the ionizable lipid and DOTAP as cationic lipid. It's specifically designed for targeted delivery of Firefly Luciferase mRNA to lung. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. The loaded Firefly Luciferase mRNA is modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| N1-Methylpseudouridine | N1-methyl-pseudouridine (1-Methylpseudouridine), a methylpseudouridine, outperforms 5 mC and 5 mC/N1-methyl-pseudouridine in translation. N1-methyl-pseudouridine in mRNA enhances translation through eIF2?-dependent and independent mechanisms by increasing ribosome density[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 1-Methylpseudouridine; N1-methyl-pseudouridine. CAS No. 13860-38-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112582. |  |
| SM102 LNP-Cap 1 EGFP mRNA (m1Ψ) | This product is a LNP prepared with ionizable lipid (SM102), helper lipid, cholesterol and PEGylated lipid, encapsulating EGFP mRNA. EGFP mRNA, a common fluorescence reporter, translates into enhanced green fluorescent protein, which exhibits an excitation wavelength of 488 nm and emission at 507 nm. The loaded EGFP mRNA is capped with the CAP 1 structure and modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| SM102 LNP-Cap 1 Fluc mRNA (m1Ψ) | This product is a LNP prepared with ionizable lipid (SM102), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. The loaded Firefly Luciferase mRNA is capped with the CAP 1 structure and modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| SM102 LNP-EGFP mRNA (m1Ψ) | This product is a LNP prepared with ionizable lipid (SM102), helper lipid, cholesterol and PEGylated lipid, encapsulating EGFP mRNA. EGFP mRNA, a common fluorescence reporter, translates into enhanced green fluorescent protein, which exhibits an excitation wavelength of 488 nm and emission at 507 nm. The loaded EGFP mRNA is modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| SM102 LNP-Fluc mRNA (m1Ψ) | This product is a LNP prepared with ionizable lipid (SM102), helper lipid, cholesterol and PEGylated lipid, encapsulating Firefly Luciferase mRNA. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. The loaded Firefly Luciferase mRNA is modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| Spleen Targeted SM102 LNP-Fluc mRNA (m1Ψ) | This product is a LNP prepared from SM102 as the ionizable lipid and 18:1 PA as cationic lipid. It's specifically designed for targeted delivery of Firefly Luciferase mRNA to spleen. Firefly Luciferase mRNA, a fluorescence reporter, encodes an enzyme that catalyzes the oxidation of luciferin to oxyluciferin, producing bioluminescence. The loaded Firefly Luciferase mRNA is modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
| T cells Targeted SM102 LNP-EGFP mRNA (m1Ψ) | This product is a LNP prepared from SM102 as the ionizable lipid and modified with CD3 antibody. It's specifically designed for targeted delivery of EGFP mRNA to CD3+ T cells. EGFP mRNA, a common fluorescence reporter, translates into enhanced green fluorescent protein, which exhibits an excitation wavelength of 488 nm and emission at 507 nm. The loaded EGFP mRNA is modified with N1-methyl-pseudouridine to enhance expression and reduce immunogenicity. It is only for research purposes. Group: Lipid nanoparticle. | |
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