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| Product | Description | |
|---|---|---|
| NAADP | NAADP, a nucleotide, is a Ca 2+ -mobilizing second messenger. NAADP is essential for initiation of Ca 2+ signaling [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 5502-96-5. Pack Sizes: 1 mg. Product ID: HY-103317. |  |
| NAADP tetrasodium salt | NAADP tetrasodium salt is a Ca2+ mobilizing agent. It is an activator of intracellular Ca2+ release via IP3 and cyclic ADP ribose-independent mechanism. Synonyms: Nicotinic acid adenine dinucleotide phosphate tetrasodium salt. Grades: ≥98% by HPLC. CAS No. 5502-96-5. Molecular formula: C21H23N6Na4O18P3. Mole weight: 832.32. |  |
| ε-NAADP? | ε-NAADP+ is a fluorescent analogue of the Ca2+ -releasing messenger β-NAADP+, the Ca2+ -releasing messenger. Synonyms: β- Nicotinic acid- 1, N6- ethenoadenine dinucleotide phosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 217313-72-9. Molecular formula: C23H27N6O18P3 (free acid). Mole weight: 768.4 (free acid). | |
| 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase | This multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP+, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase. Group: Enzymes. Synonyms: diphosphopyridine nucleosidase (ambiguous); CD38 (gene name); BST1 (gene name). Enzyme Commission Number: EC 2.4.99.20. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2705; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; EC 2.4.99.20; diphosphopyridine nucleosidase (ambiguous); CD38 (gene name); BST1 (gene name). Cat No: EXWM-2705. |  |
| cis-Ned 19 | cis-Ned 19 is a irreversible nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist, which inhibits Ca2+ release (IC50 = 800 nM) and [32P]NAADP binding (IC50 = 15 μM). Ned-19 has two diastereomers, the 'trans' and 'cis', the trans form was more potent than the cis form in regard to both inhibition of Ca2+ release (IC50 of 6 nM versus 800 nM) and [32P]NAADP binding (IC50 of 0.4 nM versus 15 μM). Synonyms: cis-Ned 19; cis-Ned19; cis-Ned-19; (1S,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid. Grades: ≥97% by HPLC. CAS No. 1137264-00-6. Molecular formula: C30H31FN4O3. Mole weight: 514.59. | |
| cis-Ned-19 Methyl Ester | cis-Ned-19 Methyl Ester is a side product produced during the preparation of trans-Ned-19 (N388750), a cell permeable and potent nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Group: Biochemicals. Alternative Names: (1R,3R)-1-[3-[[4-(2-Fluorophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
| ε-ADPRP | ε-ADPRP is a metabolite of ε-NADP+ and ε-NAADP+. Synonyms: 1, N6- Ethenoadenosine- 5'- O- diphosphoribose phosphate. Grades: ≥ 95% by HPLC. CAS No. 98088-66-5. Molecular formula: C17H24N5O17P3 (free acid). Mole weight: 663.3 (free acid). | |
| Ned-K | Ned-K, a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist, effectively inhibits Ca2+ oscillations induced by simulated ischemia and reperfusion (sIR) in cardiomyocytes. Synonyms: 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 1-[3-[[4-(2-cyanophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-, (1R,3S)-; (1R,3S)-1-(3-{[4-(2-Cyanophenyl)-1-piperazinyl]methyl}-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid. CAS No. 2250019-90-8. Molecular formula: C31H31N5O3. Mole weight: 521.61. | |
| trans-Ned 19 | trans-Ned 19, a structural analog of NAADP, is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist.trans-Ned 19 inhibits NAADP-mediated Ca2+ release (IC50 = 6 nM), and also inhibits [32P]NAADP binding (IC50 = 0.4 nM). It can be used as a chemical proble since it fluorescentey labels NAADP receptors in intact cells. Synonyms: (1R,3S)-1-[3-[[4-(2-Fluorophenyl)piperazin-1-yl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid; Ned-19; Ned 19; Ned19. Grades: ≥98% by HPLC. CAS No. 1354235-96-3. Molecular formula: C30H31FN4O3. Mole weight: 514.59. | |
| trans-Ned 19 | trans-Ned 19 is a NAADP antagonist and TPC blocker. trans-Ned 19 suppresses the calcium signal and the rat aorta relaxation in response to low histamine concentrations. trans-Ned 19 increases the spontaneous acrosome reaction rate, alleviates anti-CD3 mAb-induced intestinal inflammation, and improves kidney damage in mice with nephrotoxic serum nephritis [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1354235-96-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-103316. | |
| trans-Ned-19 | trans-Ned-19 is a cell permeable and potent nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. trans-Ned-19 inhibits NAADP-mediated Ca2+ release (IC50 = 6 nM) and also inhibits [32P]NAADP binding (IC50 = 0.4 nM). trans-Ned-19 can be used as a chemical proble since it fluorescentey labels NAADP receptors in intact cells. Group: Biochemicals. Alternative Names: (1R,3S)-1-[3-[[4-(2-Fluorophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-Pyrido[3,4-b]indole-3-carboxylic Acid. Grades: Highly Purified. CAS No. 1354235-96-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| trans-Ned-19 Methyl Ester | trans-Ned-19 Methyl Ester is a trans-Ned-19 (N388750) derivative, a cell permeable and potent nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Group: Biochemicals. Alternative Names: (1R,3S)-1-[3-[[4-(2-Fluorophenyl)-1-piperazinyl]methyl]-4-methoxyphenyl]-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic Acid. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
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