Nad P Enzyme Suppliers USA
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Product | Description | |
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2,3-Lutidine-N-oxide Quick inquiry Where to buy Suppliers range | 2,3-Lutidine-N-oxide can be used in biological study of enzymic reduction of pyridine- and nitropyridine-N-oxide derivs. by ferredoxin-NADP+ oxidoreductase and the role of their electron accepting potency. Group: Biochemicals. Grades: Highly Purified. CAS No. 22710-07-2. Pack Sizes: 250mg, 1g. Molecular Formula: C7H9NO, Molecular Weight: 123.15. US Biological Life Sciences. | Worldwide |
(2R)-2-Deoxy-2-fluoro-2-methyl-α-D-erythro-pentofuranose 3,5-Dibenzoate Quick inquiry Where to buy Suppliers range | (2R)-2-Deoxy-2-fluoro-2-methyl-α-D-erythro-pentofuranose 3,5-Dibenzoate has been employed in a study to investigate potent inhibitors against CD38 NADase, an enzyme involved with the metabolism of nicotinamide and calcium signalling pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 1639301-16-8. Pack Sizes: 10mg, 100mg. Molecular Formula: C20H19FO6, Molecular Weight: 374.36. US Biological Life Sciences. | Worldwide |
(2R)-2-Deoxy-2-fluoro-2-methyl- β-D-erythro-pentofuranose 3,5-Dibenzoate Quick inquiry Where to buy Suppliers range | (2R)-2-Deoxy-2-fluoro-2-methyl- β-D-erythro-pentofuranose 3,5-Dibenzoate has been employed in a study to investigate potent inhibitors against CD38 NADase, an enzyme involved with the metabolism of nicotinamide and calcium signalling pathway. It also has utility in the stereoselective synthesis of β-D-2'-Deoxy-2'-α-fluoro-2'- β-C-methyl-3',5'-cyclic phosphate nucleotide, a prodrug for treating hepatitis C virus (HCV) infection. Group: Biochemicals. Grades: Highly Purified. CAS No. 1199809-22-7. Pack Sizes: 50mg, 100mg. Molecular Formula: C20H19FO6, Molecular Weight: 374.36. US Biological Life Sciences. | Worldwide |
(2R)-2-Deoxy-2-fluoro-2-methyl- β-D-erythro-pentofuranosyl Chloride 3,5-Dibenzoate Quick inquiry Where to buy Suppliers range | (2R)-2-Deoxy-2-fluoro-2-methyl- β-D-erythro-pentofuranosyl Chloride 3,5-Dibenzoate is a related compound of (2R)-2-Deoxy-2-fluoro-2-methyl- β-D-erythro-pentofuranose 3,5-Dibenzoate (D235550) and (2R)-2-Deoxy-2-fluoro-2-methyl-α-D-erythro-pentofuranose 3,5-Dibenzoate (D235555). These compounds can be used to investigate potent inhibitors against CD38 NADase, an enzyme involved with the metabolism of nicotinamide and calcium signalling pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 1500076-79-8. Pack Sizes: 5mg, 50mg. Molecular Formula: C20H18ClFO5, Molecular Weight: 392.81. US Biological Life Sciences. | Worldwide |
3-Bromo-5-phenyl salicylic acid Quick inquiry Where to buy Suppliers range | The aldo-keto reductase (AKR) enzymes constitute a family of related NADPH-dependent oxidoreductases. 3-Bromo-5-phenyl salicylic acid selectively inhibits AKR1C1 (Ki = 4 nM) over AKR1C2 (Ki = 87 nM), AKR1C3 (Ki = 4.2 μM), and AKR1C4 (Ki = 18.2 μM). Synonyms: NSC 109116; 3-bromo-2-hydroxy-5-phenylbenzoic acid. Grades: ≥95%. CAS No. 4906-68-7. Molecular formula: C13H9BrO3. Mole weight: 293.1. | |
5-Bromo-3-phenyl salicylic acid Quick inquiry Where to buy Suppliers range | The aldo-keto reductase (AKR) enzymes constitute a family of related NADPH-dependent oxidoreductases. 5-Bromo-3-phenyl salicylic acid selectively inhibits AKR1C1 (Ki = 140 nM) over AKR1C2 (K1 = 1.97 μM) and AKR1C3 (Ki = 21 μM). Synonyms: 5-Bromo-2-hydroxy-[1,1'-biphenyl]-3-carboxylic acid. Grades: ≥98%. CAS No. 99514-99-5. Molecular formula: C13H9BrO3. Mole weight: 293.1. | |
5-O-Methyl Quercetin Quick inquiry Where to buy Suppliers range | O-Methylated analogue of the flavanoid Quercertin. It is a small molecule inhibitor of NADPH Oxidase 4 enzyme. It is used in studies of flavonoid structure requirement for the increment of ocular blood flow in the rabbit and retinal function recovery in rat eyes. Group: Biochemicals. Alternative Names: 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-5-methoxy-4H-1-benzopyran-4-one; 3,3',4,7-Tetrahydroxy-5-methoxyflavone; Azaleatin; Quercetin 5-Methyl Ether. Grades: Highly Purified. CAS No. 529-51-1. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
6-Aminonicotinamide Quick inquiry Where to buy Suppliers range | 6-Aminonicotinamide (6-AN) is a well-established inhibitor of the NADP+-dependent enzyme, 6-phosphogluconate dehydrogenase (Ki = 0.46 μM). 6-Aminonicotinamide is a PGD inhibitor and apoptosis inducer. Uses: Teratogens. Synonyms: 6-aminopyridine-3-carboxamide. Grades: 95 %. CAS No. 329-89-5. Molecular formula: C6H7N3O. Mole weight: 137.14. | |
Anacardic acid triene Quick inquiry Where to buy Suppliers range | Anacardic acid is a blanket term applied to a family of closely related compounds consisting of salicylic acid with a 15-carbon alkyl chain, which exist either in a fully saturated form or as a monoene, diene, or triene. Anacardic acid triene is a polyunsaturated form of anacardic acid that has been found in cashew nut shell liquid. Anacardic acid triene inhibits NADH oxidase with IC50 of 1.3 μg/ml, which is an enzyme involved in bacterial respiration. Anacardic acid triene is molluscicidal, inducing toxicity in B. glabrata (LC50 = 0.35 ppm), but is inactive against S. mansoni parasites. Synonyms: Anacardic Acid 15:3. Grades: ≥98%. CAS No. 103904-73-0. Molecular formula: C22H30O3. Mole weight: 342.47. | |
a-Nicotinamide mononucleotide Quick inquiry Where to buy Suppliers range | a-Nicotinamide mononucleotide is a pivotal intermediate in the bioresearch of nicotinamide adenine dinucleotide (NAD+), finding applications in studying the aging process and preserving neural integrity. Evidentially, it possesses the ability to stimulate sirtuin 1 is an NAD+-dependent enzyme, thereby augmenting mitochondrial functionality and fortifying cellular energy metabolism. Synonyms: 3-Carbamoyl-1-a-D-ribofuranosylpyridinium hydroxide,5'-phosphate, inner salt; α-nicotinamide mononucleotide; α-Nicotinamid-nucleotid; 3-carbamoyl-1-(O5-phosphono-α-D-ribofuranosyl)-pyridinium betaine; ((2R,3S,4R,5S)-5-(3-carbamoylpyridinium-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen phosphate. CAS No. 7298-94-4. Molecular formula: C11H15N2O8P. Mole weight: 334.22. | |
Apocynin Quick inquiry Where to buy Suppliers range | An inhibitor of NADPH oxidase (an enzyme responsible for reactive oxygen species production) and is useful in the treatment of various inflammatory diseases. Group: Biochemicals. Alternative Names: 1-(4-Hydroxy-3-methoxy-phenyl)ethanone; 4-Hydroxy-3-methoxyacetophenone; 4-Acetyl-2-methoxyphenol; 4-Acetylguaiacol; 4-Hydroxy-3-methoxyphenyl Methyl Ketone; 4'-Hydroxy-3'-methoxyacetophenone; Acetoguaiacon; Acetovanillone; Apocynin; Apocynine; NSC 209524; NSC 2146. Grades: Highly Purified. CAS No. 498-02-2. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
β-NADH, Reduced Disodium Salt (Nicotinamide Adenine Dinucleotide) Quick inquiry Where to buy Suppliers range | Beta-nicotinamide adenine dinucleotide hydrate. Can be used as a cofactor in reactions with NAD-dependent histone deacetylase enzymes.NAD is a coenzyme formed from the nucleotide, nicotinamide, adenosine monophosphateand a phosphate group joining the first two components. NADP has the same structure with the addition of an extra phosphate group to AMP. NAD can be reduced to NADH during coupling with reactions which oxidize various organic substrates. For example, the reaction catalyzed by glyceraldehyde phosphate dehydrogenase during glycolysis. NADH then passes to the inside of mitochondria where it donates the electrons it is carrying to the electron transport chain. In this manner, NAD acts as an intermediate energy storage compound that indirectly generates ATP. Generally, NADP accepts electrons from catabolic reactions to form NADPH. An example is its coupling with the conversion of glucose-6-phosphate to ribose-5-phosphate in the pentose phosphate pathway. NADPH has a slightly different role to NADH in that it does not donate electrons to the electron transport chain. Instead, it tends to reduce intermediates in anabolic pathways e.g. fatty acid synthesis. NAD participates in many redox reactions in cells, including those in glycolysis and most of those in the citric acid cycle of cellular respiration. Nicotinamide adenine dinucleotide (NAD) and its relative nicotinamide adenine dinucleotide phosphate (NADP) are two of the most important coenzymes in the cell. In cells, most oxidations are accomplished by the removal of hydrogen atoms. Both of these coenzymes play crucial roles in this. Each molecule of NAD+ (or NADP+) can acquire two electrons; that is, be reduced by two electrons. However, only one proton accompanies the reduction. The other proton produced as two hydrogen atoms are removed from the molecule being oxidized is liberated into the surrounding medium. Group: Biochemicals. Alternative Names: β-DPNH; β-NADH; DPNH; Diphosphopyridine nucleotide, reduced form; NADH. Grades: Highly Purified. CAS No. 606-68-8. Pack Sizes: 1g, 5g, 10g. Molecular Formula: C21H27N7O14P2Na2, Molecular Weight: 709.41. US Biological Life Sciences. | Worldwide |
β-Nicotinamide Adenine Dinucleotide Sodium Salt Hydrate Quick inquiry Where to buy Suppliers range | β-Nicotinamide Adenine Dinucleotide is a coeznyme consisting of an adenine base and a nicotinamide base connected by a pair of bridging phosphate group. β-Nicotinamide Adenine Dinucleotide acts as a coenzyme in redox reactions, as a donor of ADP-ribose moieties in ADP-ribosylation reactions and also as a precursor of the second messenger molecule cyclic ADP-ribose. β-Nicotinamide Adenine Dinucleotide also acts as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD+ to remove acetyl groups from proteins. Synonyms: Adenosine 5'-(Trihydrogen Diphosphate), P'?5'-Ester with 3-(Aminocarbonyl)-1-β-D-ribofuranosylpyridinium Hydroxide Sodium Salt Hydrate; Adenine-nicotinamide Dinucleotide Sodium Salt Hydrate; CO-I Sodium Salt Hydrate; Codehydrase I Sodium Salt Hydrate; Codehydrogenase I Sodium Salt Hydrate; Coenzyme I Sodium Salt Hydrate; Cozymase I Sodium Salt Hydrate; DPN Sodium Salt Hydrate; Diphosphopyridine Nucleotide Sodium Salt Hydrate; Enzopride Sodium Salt Hydrate; NAD Sodium Salt Hydrate; NAD+ Sodium Salt Hydrate; NSC 20272 Sodium Salt Hydrate; Nadide Sodium Salt Hydrate; Nicotinamide-adenine Dinucleotide Sodium Salt Hydrate; Oxidized diphosphopyridine Nucleotide Sodium Salt Hydrate; β-Diphosphopyridine Nucleotide Sodium Salt Hydrate; β-NAD Sodium Salt Hydrate; β-NAD+ Sodium Salt Hydrate. Grades: 95%. Molecular formula: C21H26N7NaO14P2 X(H2O). Mole weight: 685.41. | |
b-Nicotinamide adenine dinucleotide phosphate potassium salt hydrate Quick inquiry Where to buy Suppliers range | b-Nicotinamide adenine dinucleotide phosphate potassium salt hydrate exemplifies an essential coenzyme that assumes a pivotal function in diverse biochemical reactions. This compound emerges as uniquely advantageous towards interrogating cellular metabolism, enzyme kinetics and redox reactions. Synonyms: coenzyme II; b-NADP-K; Triphosphopyridine nucleotide potassium salt; TPN; [5-(6-aminopurin-9-yl)-3-hydroxy-4-(oxyphosphinyloxyphosphinyl)oxolan-2-yl]met hyl{[5- (3-carbamoylpyridyl)-3, 4-dihydroxyoxolan-2-yl]methoxy} (hydroxyphosphoryl)hydrogen phosphate,potassium salt; Beta-nadp potassium salt; Nadp monopotassium salt. Grades: ≥ 90%. CAS No. 68141-45-7. Molecular formula: C21H27KN7O17P3. Mole weight: 781.50. | |
Cadp-ribose Quick inquiry Where to buy Suppliers range | Lyophilized powder. Group: Heterocyclic Organic Compound. Alternative Names: cyclic adenosine 5-diphosphoribose; Cyclic Adenosine Diphosphate Ribose; cADP-Ribose; Cyclic ADPR; cyclic ADP-D-ribose; E-NAD; Enzyme-activated NAD; cyclic adenosine 5-diphosphate ribose; cADPR; adenosine 5-cyclic-diphosphoribose. Grades: 96%. CAS No. 119340-53-5. Molecular formula: C15H21N5O13P2. Mole weight: 541.30000. IUPAC Name: cyclic ADP-ribose. Exact Mass: 541.06100. Boiling Point: 934.8ºC at 760 mmHg. Flash Point: 519.1ºC. Density: 2.57 g/cm3. Safty Description: S26-S36. Hazard statements: Xi: Irritant. | |
Citrinin Quick inquiry Where to buy Suppliers range | Citrinin is a quinonemethine mycotoxin produced by diverse fungal genera, including Aspergillus and Penicillium. Citrinin has been extensively investigated. It is a potent nephrotoxin with hepatoxic and teratogenic activity. It is the causative agent of Balkan nephropathy and yellow rice fever in humans. At the molecular level, citrinin exhibits a range of effects including free radical damage to DNA and disruption to a wide variety of mitochrondrial membrane-bound enzymic activities and structural integrity. Specifically, citrinin is an inhibitor of NADH dehydrogenase in the mitochondrial electron transport chain and this action is responsible for recent reports of citrinin's apoptotic activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 518-75-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
D-Glucose-6-phosphate dipotassium salt trihydrate Quick inquiry Where to buy Suppliers range | D-Glucose-6-phosphate dipotassium salt trihydrate - a biochemical regularly applied in the biomedical sector. This extraordinary substrate advances NADPH production through enzyme facilitation, which partakes in paramount physiological activities such as cholesterol and fatty acid synthesis. Furthermore, D-Glucose-6-phosphate dipotassium salt trihydrate is pivotal in addressing multiple metabolic illnesses including malaria and liver disease. Its therapeutic value bolsters its placement as an integral constituent in numerous healthcare-related research endeavors. Synonyms: Dipotassium glucose-6-phosphate; D-Glucose-6-phosphate Dipotassium Salt. Grades: 98%. CAS No. 5996-17-8. Molecular formula: C6H11K2O9P. Mole weight: 336.32. | |
D-Glucose-6-phosphate disodium salt Quick inquiry Where to buy Suppliers range | D-Glucose-6-phosphate disodium salt, a crucial biochemical intermediate involved in glucose metabolism, has multifaceted functions ranging from synthesizing glycogen or generating NADPH for cellular biosynthesis via the pentose phosphate pathway. Its use extends beyond being a mere metabolite to offerings as diverse as being a key component in enzymatic assays to measure glucose-6-phosphate dehydrogenase activity. Furthermore, its central role in metabolic maladies, including type 2 diabetes, cannot be understated. Synonyms: Robison ester disodium salt. CAS No. 3671-99-6. Molecular formula: C6H11Na2O9P. Mole weight: 304.1. | |
Dihydro Finasteride Quick inquiry Where to buy Suppliers range | The reduced product of Finasteride : a mechanism-based inhibitor of human prostate and skin steroid 5α-reductase. It forms an enzyme-bound NADP-dihydrofinasteride adduct during this inhibitory process. Group: Biochemicals. Alternative Names: (4aR, 4bS, 6aS, 7S, 9aS, 9bS, 11aR) -N- (1, 1-Dimethylethyl) hexadecahydro-4a, 6a-dimethyl-2-oxo-1H-indeno[5, 4-f]quinoline-7-carboxamide; Dihydroproscar; (5α,17 β)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrostane-17-carboxamide; [4aR-(4aα,4b β, 6aα, 7α, 9a β,9bα,11a β ) ]-N- (1, 1-Dimethylethyl) hexadecahydro-4a, 6a-dimethyl-2-oxo-1H-indeno[5, 4-f]quinoline-7-carboxamide; 1,2-Dihydrofinasteride; 3-Oxo-4-aza-5α-androstan-17 β-carboxylic acid N-(tert-butyl)amide; N-(tert-Butyl)-3-oxo-4-aza-5α-androstane-17 β-carboxamide. Grades: Highly Purified. CAS No. 98319-24-5. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
EDA-ADP - ATTO-633 Quick inquiry Where to buy Suppliers range | EDA-ADP ATTO-633 - a ground-breaking fluorescent probe that has forever shifted the biomedicine landscape. This astounding tool unravels enzymatic processes affiliated with ADP-ribose metabolism. Be amazed by its ability to track enzymes that regulate NAD+ homeostasis and poly(ADP-ribose) glycohydrolase activity, then discover its grandeur in the crucial roles it plays in DNA repair and apoptosis studies. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Adenosine-5'-diphosphate, labeled with ATTO 633, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C13H21N7O11P2- ATTO 633 (free acid). Mole weight: 1046.29 (free acid). | |
FK-866 Quick inquiry Where to buy Suppliers range | Nampt/visfatin inhibitor. Inhibitor of NAD+ biosynthesis. Inhibits the enzyme/substrate complex and the free enzyme (Ki = 0.4nM and Ki = 0.3nM, respectively). Apoptosis inducer. Autophagy inducer. Causes premature senescence. Angiogenesis inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 658084-64-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C24H29N3O2. US Biological Life Sciences. | Worldwide |
Meldola Blue Quick inquiry Where to buy Suppliers range | A biosensor for the measurement of lactate in serum has been developed, which is based on a screen-printed carbon electrode, modified with Meldola's Blue-Reinecke Salt (MBRS-SPCE), coated with the enzyme lactate dehydrogenase NAD+ dependent (from Porcine heart), and NAD+. A cellulose acetate layer was deposited on the top of the device to act as a permselective membrane. Group: Biochemicals. Alternative Names: 9- (Dimethylamino) benzo[a]phenoxazin-7-ium Chloride Zinc Chloride; Meldola's Blue; Zinc Chloride 9- (Dimethylamino) benzo[a]phenoxazin-7-ium Chloride; Basic Leather Blue D; Meldola Blue. CAS No. 7057-57-0. Pack Sizes: 2.5mg. Molecular Formula: C??H??ClN?O xZnCl?. US Biological Life Sciences. | Worldwide |
N-Acetyl-2,3-dehydro-2-deoxyneuraminic acid Quick inquiry Where to buy Suppliers range | N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid is a potent neuraminidase (sialidase) inhibitor. It shows inhibitory activities against human neuraminidase enzymes with IC50s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Uses: Enzyme inhibitors. Synonyms: NADNA; 2,3-Dehydro-2-deoxy-N-acetylneuraminic acid. Grades: ≥98% (HPLC). CAS No. 24967-27-9. Molecular formula: C11H17NO8. Mole weight: 291.25. | |
NADH Thio, Reduced (Nicotinamide Adenine Dinucleotide), Thio-NADH) Quick inquiry Where to buy Suppliers range | Beta-nicotinamide adenine dinucleotide hydrate. Can be used as a cofactor in reactions with NAD-dependent histone deacetylase enzymes.NAD is a coenzyme formed from the nucleotide, nicotinamide, adenosine monophosphateand a phosphate group joining the first two components. NADP has the same structure with the addition of an extra phosphate group to AMP. NAD can be reduced to NADH during coupling with reactions which oxidize various organic substrates. For example, the reaction catalyzed by glyceraldehyde phosphate dehydrogenase during glycolysis. NADH then passes to the inside of mitochondria where it donates the electrons it is carrying to the electron transport chain. In this manner, NAD acts as an intermediate energy storage compound that indirectly generates ATP. Generally, NADP accepts electrons from catabolic reactions to form NADPH. An example is its coupling with the conversion of glucose-6-phosphate to ribose-5-phosphate in the pentose phosphate pathway. NADPH has a slightly different role to NADH in that it does not donate electrons to the electron transport chain. Instead, it tends to reduce intermediates in anabolic pathways e.g. fatty acid synthesis. NAD participates in many redox reactions in cells, including those in glycolysis and most of those in the citric acid cycle of cellular respiration. Nicotinamide adenine dinucleotide (NAD) and its relative nicotinamide adenine dinucleotide phosphate (NADP) are two of the most important coenzymes in the cell. In cells, most oxidations are accomplished by the removal of hydrogen atoms. Both of these coenzymes play crucial roles in this. Each molecule of NAD+ (or NADP+) can acquire two electrons; that is, be reduced by two electrons. However, only one proton accompanies the reduction. The other proton produced as two hydrogen atoms are removed from the molecule being oxidized is liberated into the surrounding medium. For NAD, the reaction is thus:NAD+ + 2H -> NADH + H+. Group: Biochemicals. Alternative Names: Nicotinamide Adenine Dinucleotide; Thio-NADH; Thionicotinamide adenine dinucleotide. Grades: Highly Purified. CAS No. 1921-48-8. Pack Sizes: 100mg. Molecular Formula: C21H29N7O13SP2, Molecular Weight: 681.51. US Biological Life Sciences. | Worldwide |
NAD+, Lithium salt Quick inquiry Where to buy Suppliers range | NAD+, Lithium salt is the salt form of NAD+, which is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It plays a role in the activity of several enzymes, such as poly(ADP)-ribose polymerases and cADP-ribose synthases. NAD+ is commonly used as an oxidizing agent. Nutritional supplement in health care products. Uses: Ingredient of health care products. Synonyms: β-Nicotinamide adenine Dinucleotide, Li; Beta-NAD lithium salt; Nicotinamide adenine dinucleotide lithium salt. CAS No. 64417-72-7. Molecular formula: C21H26LiN7O14P2. Mole weight: 669.362. | |
NADP-dependent malic enzyme (224-232) Quick inquiry Where to buy Suppliers range | NADP-dependent malic enzyme. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-217. | |
NADP-dependent malic enzyme (224-232) Quick inquiry Where to buy Suppliers range | NADP-dependent malic enzyme (224-232) is a bioactive peptide of NADP-dependent malic enzyme. NADP-dependent malic enzyme takes a part in crassulacean acid metabolism photosynthesis. Synonyms: NADP-ME (224-232). | |
Niacin (Nicotinic acid) Quick inquiry Where to buy Suppliers range | Nicotinic acid. It is a precursor of the coenzymes NAD and NADP. Widely distributed in nature; appreciable amounts are found in liver , fish, yeast and cereal grains. Dietary deficiency is associated with pellagra. The term niacin has also been applied to nicotinamide or to other derivatives exhibiting the biological activity of nicotinic acid. Vitamin (enzyme cofactor). Group: Biochemicals. Alternative Names: Nicotinic acid; Vitamin B3; 3-Pyridinecarboxylic Acid; 3-Carboxylpyridine; 3-Carboxypyridine; Akotin; Apelagrin; Niacin; Niacor; Niaspan; Nicacid; Pelonin; Vitamin B5; Wampocap; β-Pyridinecarboxylic Acid. Grades: Cell Culture Grade. CAS No. 59-67-6. Pack Sizes: 100g, 500g, 1Kg. Molecular Formula: C6H5NO2, Molecular Weight: 123.11. US Biological Life Sciences. | Worldwide |
Nicotinamide Adenine Dinucleotide Cyclohexanone Quick inquiry Where to buy Suppliers range | Nicotinamide Adenine Dinucleotide Cyclohexanone (NADH) is a pivotal molecular entity within the biomedical sector. Its involvement spans across diverse metabolic pathways is assuming the role of a fundamental cofactor for a myriad of enzymatic reactions. Synonyms: [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-[3-carbamoyl-4-[(1S)-2-oxocyclohexyl]pyridin-1-ium-1-yl]-3,4-dihydroxyoxolan-2-yl]methyl phosphate. Molecular formula: C27H35N7O15P2. Mole weight: 759.55. | |
Nicotinamide-d4 Quick inquiry Where to buy Suppliers range | Labelled Nicotinamide, precursor of the coenzymes NAD and NADP. Nicotinamide is a water soluble vitamin (enzyme cofactor). Group: Biochemicals. Alternative Names: 3-Pyridinecarboxamide-d4, 3- (Aminocarbonyl) pyridine-d4, 3-Amidopyridine-d4, 3-Carbamoylpyridine-d4, 3-Pyridinecarboxylic acid amide-d4, Aminicotin-d4, Benicot-d4, Nicosylamide-d4, Nicotilamide-d4, Nicotinic Acid Amide-d4, Vitamin B-d4, Vitamin B3-d4. Grades: Highly Purified. CAS No. 347841-88-7. Pack Sizes: 2.5mg. Molecular Formula: C6H2D4N2O, Molecular Weight: 126.15. US Biological Life Sciences. | Worldwide |
Nicotinamide-d4 (Major) Quick inquiry Where to buy Suppliers range | Labeled Nicotinamide, precursor of the coenzymes NAD and NADP. Nicotinamide is a water soluble vitamin (enzyme cofactor). Group: Biochemicals. Alternative Names: 3-Pyridinecarboxamide-d4; 3- (Aminocarbonyl) pyridine-d4; 3-Amidopyridine-d4; 3-Carbamoylpyridine-d4; 3-Pyridinecarboxylic acid amide-d4; Aminicotin-d4; Benicot-d4. Grades: Highly Purified. CAS No. 347841-88-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Nicotinic Acid-13C6,d4 Quick inquiry Where to buy Suppliers range | Labeled Nicotinic acid. It is a precursor of the coenzymes NAD and NADP. Widely distributed in nature; appreciable amounts are found in liver, fish, yeast and cereal grains. Dietary deficiency is associated with pellagra. The term niacin has also been applied to nicotinamide or to other derivatives exhibiting the biological activity of nicotinic acid. Vitamin (enzyme cofactor). Group: Biochemicals. Alternative Names: 3-Pyridinecarboxylic Acid-13C6,d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Nicotinic Acid, 99.5-100.5% USP Quick inquiry Where to buy Suppliers range | Nicotinic acid. It is a precursor of the coenzymes NAD and NADP. Widely distributed in nature; appreciable amounts are found in liver , fish, yeast and cereal grains. Dietary deficiency is associated with pellagra. The term niacin has also been applied to nicotinamide or to other derivatives exhibiting the biological activity of nicotinic acid. Vitamin (enzyme cofactor). Group: Biochemicals. Alternative Names: Nicotinic acid; Vitamin B3; 3-Pyridinecarboxylic Acid; 3-Carboxylpyridine; 3-Carboxypyridine; Akotin; Apelagrin; Niacin; Niacor; Niaspan; Nicacid; Pelonin; Vitamin B5; Wampocap; β-Pyridinecarboxylic Acid. Grades: USP. CAS No. 59-67-6. Pack Sizes: 100g, 500g, 1Kg. US Biological Life Sciences. | Worldwide |
Nicotinic Acid Adenine Dinucleotide Quick inquiry Where to buy Suppliers range | Nicotinic Acid Adenine Dinucleotide is an analog of β-Nicotinamide Adenine Dinucleotide; a coenzyme consisting of an adenine base and a nicotinamide base connected by a pair of bridging phosphate groups. β-Nicotinamide Adenine Dinucleotide acts as a coenzyme in redox reactions, as a donor of ADP-ribose moieties in ADP-ribosylation reactions and also as a precursor of the second messenger molecule cyclic ADP-ribose. β-Nicotinamide Adenine Dinucleotide also acts as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD+ to remove acetyl groups from proteins. Synonyms: Adenosine 5'-(trihydrogen diphosphate), P'?5'-ester with 3-carboxy-1-β-D-ribofuranosylpyridinium, inner salt; 3-Carboxy-1-β-D-ribofuranosylpyridinium hydroxide, 5'-ester with adenosine 5'-pyrophosphate, inner salt; Pyridinium, 3-carboxy-1-β-D-ribofuranosyl-, hydroxide, 5'?5'-ester with adenosine 5'-(trihydrogen pyrophosphate), inner salt; 1: PN: WO2006081329 PAGE: 47 claimed sequence; Adenine-nicotinic Acid Dinucleotide; Codehydrogenase I, carboxy deamido analog; Codehydrogenase I, nicotinic acid analog; Deamido-NAD; Deamidodiphosphopyridine Nucleotide; Desamido NAD; Nicotinate Adenine Dinucleotide; Nicotinic Acid-adenine Dinucleotide. CAS No. 6450-77-7. Molecular formula: C21H26N6O15P2. Mole weight: 664.41. | |
Nicotinic Acid-d1 Quick inquiry Where to buy Suppliers range | Labeled Nicotinic acid. It is a precursor of the coenzymes NAD and NADP. Widely distributed in nature; appreciable amounts are found in liver, fish, yeast and cereal grains. Dietary deficiency is associated with pellagra. The term niacin has also been applied to nicotinamide or to other derivatives exhibiting the biological activity of nicotinic acid. Vitamin (enzyme cofactor). Group: Biochemicals. Alternative Names: 3-Pyridinecarboxylic Acid-d1; 3-Carboxylpyridine-d1; 3-Carboxypyridine-d1; Akotin-d1; Apelagrin-d1; Niacin-d1; Niacor-d1; Niaspan-d1; Nicacid-d1; Pelonin-d1; Vitamin B3-d1; Vitamin B5-d1; Wampocap-d1; β-Pyridinecarboxylic Acid-d1. Grades: Highly Purified. CAS No. 116975-14-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Nicotinic Acid-d3 (major) Quick inquiry Where to buy Suppliers range | Labeled Nicotinic acid. It is a precursor of the coenzymes NAD and NADP. Widely distributed in nature; appreciable amounts are found in liver, fish, yeast and cereal grains. Dietary deficiency is associated with pellagra. The term niacin has also been applied to nicotinamide or to other derivatives exhibiting the biological activity of nicotinic acid. Vitamin (enzyme cofactor). A representative lot contains >20% d4. Group: Biochemicals. Alternative Names: 3-Pyridinecarboxylic Acid-d3; 3-Carboxylpyridine-d3; 3-Carboxypyridine-d3; Akotin-d3; Apelagrin-d3; Niacin-d3; Niacor-d3; Niaspan-d3; Nicacid-d3; Pelonin-d3; Vitamin B3-d3; Vitamin B5-d3; Wampocap-d3; β-Pyridinecarboxylic Acid-d3. Grades: Highly Purified. CAS No. 861405-75-6. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
Nicotinic Acid-d4 Quick inquiry Where to buy Suppliers range | Labeled Nicotinic acid. It is a precursor of the coenzymes NAD and NADP. Widely distributed in nature; appreciable amounts are found in liver, fish, yeast and cereal grains. Dietary deficiency is associated with pellagra. The term niacin has also been applied to nicotinamide or to other derivatives exhibiting the biological activity of nicotinic acid. Vitamin (enzyme cofactor). Group: Biochemicals. Alternative Names: 3-Pyridinecarboxylic Acid-d4. Grades: Highly Purified. CAS No. 66148-15-0. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
Ormetoprim Quick inquiry Where to buy Suppliers range | It is a potent and selective inhibitor of bacterial dihydrofolate reductase, the enzyme responsible for the NADPH-dependent reduction of 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate. Antibacterial. Group: Biochemicals. Alternative Names: 2, 4-Diamino-5- (6-methylveratryl) pyrimidine; 2, 4-Diamino-5-92-methyl-4, 5-dimethoxybenzyl) pyrimidine; Diamino-5- (6-methylveratryl) pyrimidine; NSC 95072; Ormethoprim; Ro 5-9754. Grades: Highly Purified. CAS No. 6981-18-6. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
Oxalacetic Acid (Oxaloacetic acid) Quick inquiry Where to buy Suppliers range | A four carbon dicarboxylic acid that is an intermediate in the citric acid cycle and glucogenesis. It has been shown to inhibit succinate dehydrogenase. Oxaloacetic acid, in the form of its conjugate base oxaloacetate, is a metabolic intermediate in many processes that occur in animals. It takes part in the: gluconeogenesis, urea cycle, glyoxylate cycle, amino acid synthesis, fatty acid synthesis and citric acid cycle. Gluconeogenesis[1] is a metabolic pathway consisting of a series of eleven enzyme-catalyzed reactions, resulting in the generation of glucose from non-carbohydrates substrates. The beginning of this process takes place in the mitochondrial matrix, where pyruvate molecules are found. A pyruvate molecule is carboxylated by a pyruvate carboxylase enzyme, activated by a molecule each of ATP and water. This reaction results in the formation of oxaloacetate. NADH reduces oxaloacetate to malate. This transformation is needed to transport the molecule out of the mitochondria. On Group: Biochemicals. Alternative Names: Oxobutanedioic Acid; Oxalacetic Acid; 2-Ketosuccinic acid; 2-Oxobutanedioic acid; 2-Oxosuccinic Acid; Ketosuccinic Acid; NSC 284205; NSC 77688; OAA; Oxaloacetic Acid; Oxaloethanoic Acid; Oxosuccinic Acid; α-Ketosuccinic Acid. Grades: Reagent Grade. CAS No. 328-42-7. Pack Sizes: 25g, 50g, 100g, 250g. Molecular Formula: C?H?O?, Molecular Weight: 132.07. US Biological Life Sciences. | Worldwide |
R162 Quick inquiry Where to buy Suppliers range | R162 is a potent, selective inhibitor of glutamate dehydrogenase 1 (GDH1) (Ki = 28.6 μM), with anti-cancer properties. It does not inhibit the activity of other NADPH enzymes such as 6-phosphogluconate dehydrogenase and fumarate hydratase. Synonyms: R 162; R-162; 2-allyl-1-hydroxy-anthraquinone; 2-allyl-1-hydroxyanthra-9,10-quinone. CAS No. 64302-87-0. Molecular formula: C17H12O3. Mole weight: 264.28. | |
RH1 Quick inquiry Where to buy Suppliers range | RH1 is a new bioreductive agent that is an excellent substrate for the two-electron reducing enzyme, NAD(P)H quinone oxidoreductase 1 (NQO1). In phase trials, RH1 was well tolerated with predictable and manageable toxicity. The MTD of 1430 μg/m(2)/day is the dose recommended for phase II trials. The biomarkers of DNA cross linking, DTD activity and NQO1 status have been validated and clinically developed. Synonyms: RH 1; RH-1; NSC697726; 2,5-di(aziridin-1-yl)-3-(hydroxymethyl)-6-methylcyclohexa-2,5-diene-1,4-dione. CAS No. 221635-42-3. Molecular formula: C12H14N2O3. Mole weight: 234.25. | |
Riboflavin-5-Phosphate Disodium Salt (Flavin mononucleotide, FMN) Quick inquiry Where to buy Suppliers range | Flavin mononucleotide (FMN), or riboflavin-5?-phosphate, is a biomolecule produced from riboflavin (vitamin B2) by the enzyme riboflavin kinase and functions as prosthetic group of various oxidoreductases including NADH dehydrogenase as well as cofactor in biological blue-light photo receptors. During the catalytic cycle, a reversible interconversion of the oxidized (FMN), semiquinone (FMNH ) and reduced (FMNH2) forms occurs in the various oxidoreductases. FMN is a stronger oxidizing agent than NAD and is particularly useful because it can take part in both one- and two-electron transfers. In its role as blue-light photo receptor, (oxidized) FMN stands out from the 'conventional' photo receptors as the signaling state and not an E/Z isomerization. Group: Biochemicals. Alternative Names: Flavin mononucleotide disodium salt; FMN. Grades: Purified. CAS No. 130-40-5. Pack Sizes: 25g, 50g, 100g. US Biological Life Sciences. | Worldwide |
STK393606 Quick inquiry Where to buy Suppliers range | STK393606 is a competitive and selective inhibitor of NAD+-dependent type-I 15-hydroxy PGDH, an enzyme activating PGs via converting the oxidation of primary PGs to their 15-keto metabolites. Synonyms: 2-(6-Bromo-3H-imidazo[4,5-b]pyridin-2-ylsulfanylmethyl)-benzonitrile. Grades: ≥98%. CAS No. 355827-05-3. Molecular formula: C14H9BrN4S. Mole weight: 345.2. | |
Streptonigrin (Bruneomycin, Nigrin, Rufocromomycin, Valacidin, Antibiotic RP 5278) Quick inquiry Where to buy Suppliers range | Streptonigrin is an unusual aminoquinone with broad biological activity against bacteria, fungi, nematodes, viruses and tumor cells. Streptonigrin acts as a bioreductive agent, highly dependent on interactions with metal ions, notably iron, and plays an important role in free radical production through redox cycling of NAD(P)H:quinone oxidoreductase (NQO1). Streptonigrin from Streptomyces flocculus is an aminoquinone antitumor antibiotic. Its antineoplastic activity requires reductive activation by Xanthine-converting enzymes. It induces apoptosis by a mechanism involving NF-κB. DNA cleavage reaction and chromosome damage by Streptonigrin are influenced by the nature of the metal ion present and dependent on the production of free radicals. Its antibiotic activity is iron-activated. Group: Biochemicals. Alternative Names: EC Number 223-501-8; 5278RP; AO 50165L302; Abbott Crystalline antibiotic; Bruneomycin; NSC 45383; NSC 56748; NSC 83950; Nigrin; Rufocromomycin; SN; STP; Streptonigran; Streptonigrin; 5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic Acid; (4R)-5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolinyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methyl-2-pyridinecarboxylic Acid; (R)-Streptonigrin. Grades: Highly Purified. CAS No. 3930-19-6. Pack Sizes: 1mg. Molecular Formula: C??H??N?O?, Molecular Weight: 506.46. US Biological Life Sciences. | Worldwide |
Tankyrase1/2 Inhibitor III (TNKS1/2 Inhibitor III, Wnt Pathway Inhibitor XIV, 3-(4-Methoxyphenyl)-5-((4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-ylthio)methyl)-1,2,4-oxadiazole) Quick inquiry Where to buy Suppliers range | A cell-permeable triazolylthiomethyl-oxadiazole compound that binds TNKS1/PARP5a and TNKS2/PARP5b with high affinity (=79 and 28nM, respectively), and acts as a potent and reversible TNKS1/2 dual inhibitor (IC50=33nM TNKS2 in an auto-PARsylation assay). Shown to interact with the adenosine diphosphate linker portion of the NAD+ donor site, and display excellent selectivity over PARP1 and PARP2 activities (IC50>19uM); stabilize Axin2 levels (EC50=709nM in SW480 cells), and antagonize Wnt signaling (IC50=215nM in HEK293-SuperTopFlash assay). Exhibits minimal activity towards cytochrome P450 enzymes (IC50=21 and 5.7uM for CYP2C9 and CYP3A4) and hERG ion channel (IC50>30uM), and adequate microsomal stability. Group: Biochemicals. Grades: Highly Purified. CAS No. 865565-29-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Tiazofurin Quick inquiry Where to buy Suppliers range | Tiazofurin is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin (TR) is anabolized intracellularly to an analogue of NAD, tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH); IMPDH is the rate-limiting enzyme for de novo purine synthesis. Inhibition of IMPDH results in reduced levels of guanylates, resulting in the inhibition tumor cell growth in vitro and in vivo. Uses: Antineoplastic agents. Synonyms: 2-b-D-Ribofuranosyl-4-thiazolecarboxamide; CI 909; NSC 286-193. Grades: 97%. CAS No. 60084-10-8. Molecular formula: C9H12N2O5S. Mole weight: 260.27. | |
VJ115 Quick inquiry Where to buy Suppliers range | VJ115 is a novel chemical entity that inhibits the enzyme ENOX1, a NADH oxidase. Genetic and small molecule inhibition of ENOX1 inhibits endothelial cell tubule formation and tumor-mediated neo-angiogenesis. VJ115 inhibition of ENOX1 can impact expression of proteins involved in cytoskeletal reorganization and support a hypothesis in which ENOX1 activity links elevated cellular NADH concentrations with cytoskeletal reorganization and angiogenesis. Synonyms: VJ 115; VJ-115; (Z)-2-((1-benzyl-1H-indol-3-yl)methylene)quinuclidin-3-ol. CAS No. 929256-79-1. Molecular formula: C23H24N2O. Mole weight: 344.45. |