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| Product | Description | |
|---|---|---|
| Naphthoquine phosphate | Naphthoquine phosphate and artemisinine are two antimalarials developed in China. Both drugs have proven to be efficacious and well tolerated as monotherapy as well as in combination in patients suffering from malaria. The Co-naphthoquine, a novel antimalarial combination, is an oral fixed combination tablet of the naphthoquine phosphate and artemisinine. Artemisinin is characterised by a rapid onset of schizonticidal action and a short half-life. Parasite clearance is, however, often incomplete when it is employed as a single agent unless high dosages are used over several days, but such a regimen may reduce patient compliance and increase the danger of toxicity. Naphthoquine phosphate, by contrast, has a slower onset of action and a longer half-life, associated with a low recrudescence rate. Synonyms: 1-Naphthalenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[[(1,1-dimethylethyl)amino]methyl]-5,6,7,8-tetrahydro-, phosphate (1:2) (salt); 2-((tert-butylamino)methyl)-4-((7-chloroquinolin-4-yl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol bis(phosphate); Naphthoquine diphosphate. Grades: >98%. CAS No. 173531-58-3. Molecular formula: C24H34ClN3O9P2. Mole weight: 605.94. |  |
| Naphthoquine phosphate | Naphthoquine phosphate is a potent and orally active antimalarial agent. Naphthoquine phosphate has thorough killing function for various schizonts of plasmodia , including resistance of P. falciparum to Chloroquine [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 173531-58-3. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-17036. |  |
| Cdc25 Inhibitor IV, NSC 95397 (2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedione, PTP Inhibitor XXIX) | A cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (Ki=32nM, 96nM, and 40nM for Cdc25A, -B, and -C, respectively) and blocks G2M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC50=1.8uM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments. Group: Biochemicals. Grades: Highly Purified. CAS No. 93718-83-3. Pack Sizes: 10mg. Molecular Formula: C??H??O?S?, Molecular Weight: 310.4. US Biological Life Sciences. |  Worldwide |
| NAD(P)H dehydrogenase (quinone) | A flavoprotein. The enzyme catalyses a two-electron reduction and has a preference for short-chain acceptor quinones, such as ubiquinone, benzoquinone, juglone and duroquinone. The animal, but not the plant, form of the enzyme is inhibited by dicoumarol. Group: Enzymes. Synonyms: menadione reductase; phylloquinone reductase; quinone reductase; dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone); DT-diaphorase; f. Enzyme Commission Number: EC 1.6.5.2. CAS No. 9032-20-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1591; NAD(P)H dehydrogenase (quinone); EC 1.6.5.2; 9032-20-6; menadione reductase; phylloquinone reductase; quinone reductase; dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone); DT-diaphorase; flavoprotein NAD(P)H-quinone reductase; menadione oxidoreductase; NAD(P)H dehydrogenase; NAD(P)H menadione reductase; NAD(P)H-quinone dehydrogenase; NAD(P)H-quinone oxidoreductase; NAD(P)H: (quinone-acceptor)oxidoreductase; NAD(P)H: menadione oxidoreductase; NADH-menadione reductase; naphthoquinone reductase; p-benzoquinone reductase; reduced NAD(P)H dehydrogenase; viologen accepting pyridine nucleotide oxidoreductase; vitamin K reductase; diaphorase; reduced nicotinamide-adenine dinucleotide (phosphate) dehy |  |
| NSC 95397 | NSC 95397 is a 1,4-naphthoquinone-based irreversible inhibitor of Cdc25 dual-specificity phosphatases (Ki = 32, 96 and 40 nM for inhibition of Cdc25A, -B and -C respectively). NSC 95397 exhibits 125-180-fold selectivity over VH1-related dual-specificity phosphatase and protein tyrosine phosphatase 1b. Synonyms: 2,3-bis[(2-Hydroxyethyl)thiol]-1,4-naphthoquinone; NSC-95397; NSC95397; NSC 95397. Grades: ≥97% by HPLC. CAS No. 93718-83-3. Molecular formula: C14H14O4S2. Mole weight: 310.38. | |
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