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It is a 10-membered macrocyclic lactone antibiotic produced by Nocardia sp. It exhibits potent activity against gram-positive bacteria. It has been shown to enhance retinoate-induced cell differentiation. Synonyms: Nargenicin B1; CP 51467; Antibiotic CP 51467. Grades: >99% by HPLC. CAS No. 75923-01-2. Molecular formula: C28H37NO8. Mole weight: 515.60.
Nargenicin A1
Antibiotic against Gram-positive bacteria, particularly Staphylococcus and Clostridia. More effective against multi-resistant strains (MRSA) than erythromycin and vancomycin. Inhibits cell proliferation and induces HL-60 cell differentiation in combination with 1,25-Dihydroxyvitamin-D3 and ATRA. Displays low cytotoxicity compared to erythromycin and spiramycin. Group: Biochemicals. Alternative Names: Antibiotic 47444; CP 47444; NSC 355066; Nargenicin; Nargenicin A1; Stereoisomer of 3, 4, 6, 7, 8, 8a, 10a, 11, 12, 13, 14, 14a-dodecahydro-14-hydroxy-4-(1-hydroxyethyl)-7-methoxy-1, 3, 13-trimethyl-6-oxo-11, 14b-epoxy-14bH-naphth[2, 1-e]oxecin-12-yl 1H-pyrrole-2-carboxylate; [3R-[1E, 3R*, 4S*(R*), 7S*, 8aS*, 10aR*, 11R*, 12R*, 13R*, 14R*, 14aS*, 14bS*]]-1H-Pyrrole-2-carboxylic acid 3, 4, 6, 7, 8, 8a, 10a, 11, 12, 13, 14, 14a-Decahydro-14-hydroxy-4-(1-hydroxyethyl)-7-methoxy-1, 3, 13-trimethyl-6-oxo-11, 14b-epoxy-14bH-naphth[2, 1-e]oxecin-12-yl Ester; 9-(1H-Pyrrole-2-carboxylate) Nodusmicin. Grades: Highly Purified. CAS No. 70695-02-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??NO?. US Biological Life Sciences.
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Nargenicin A1
Nargenicin A1 is a macrolide antibiotic produced by Nocardia sp. that is effective against Gram-positive bacteria including taphylococcus and Clostridia. It shows more potent efficacy against methicilin resistant S. aureus (MRSA) than erythromycin and vancomycin. Synonyms: Antibiotic 47444; CP 47444; NSC 355066; Nodusmicin 9-(1H-pyrrole-2-carboxylate); 1H-Pyrrole-2-carboxylic acid, (1E, 3R, 4S, 7S, 8aS, 10aR, 11R, 12R, 13R, 14R, 14aS, 14bS)-3, 4, 6, 7, 8, 8a, 10a, 11, 12, 13, 14, 14a-dodecahydro-14-hydroxy-4-[(1R)-1-hydroxyethyl]-7-methoxy-1, 3, 13-trimethyl-6-oxo-11, 14b-epoxy-14bH-naphth[2, 1-e]oxecin-12-yl ester. Grades: ≥99%. CAS No. 70695-02-2. Molecular formula: C28H37NO8. Mole weight: 515.60.
Nodusmicin
It is an antibiotic produced by the strain of Saccharopolyspora hirsuta and Nocardia argentinensis. It is a co-metabolite of nargenicin, bearing the core macrocyclic lactone but lacking the pyrrole ester. It has anti-gram-positive bacteria and anaerobic bacteria activity. Synonyms: Antibiotic U 59761; Nodusmicin 1; [3R-[1E, 3R*, 4S*(R*), 7S*, 8aS*, 10aR*, 11R*, 12R*, 13R*, 14R*, 14aS*, 14bS*]]-3, 4, 8, 8a, 10a, 11, 12, 13, 14, 14a-Decahydro-12, 14-dihydroxy-4-(1-hydroxyethyl)-7-methoxy-1, 3, 13-trimethyl-11, 14b-epoxy-14bH-naphth[2, 1-e]oxecin-6(7H)-one; (1E, 3R, 4S, 7S, 8aS, 10aR, 11R, 12R, 13R, 14R, 14aS, 14bS)-3, 4, 8, 8a, 10a, 11, 12, 13, 14, 14a-decahydro-12, 14-dihydroxy-4-[(1R)-1-hydroxyethyl]-7-methoxy-1, 3, 13-trimethyl-11, 14b-epoxy-14bH-naphth[2, 1-e]oxecin-6(7H)-one; U 59761. Grades: >99% by HPLC. CAS No. 76265-48-0. Molecular formula: C23H34O7. Mole weight: 422.51.
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