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| Product | Description | |
|---|---|---|
| ND-630 | ND-630, also called as NDI 010976, is a highly selective, reversible inhibitor of acetyl-CoA carboxylase (ACC) and had IC50 values of 2 and 7 nM for ACC1 and 2, respectively, EC50 values in HepG2 serum free and 10% serum of 9 and 66 nM, respectively, and 2-fold C2C12 fatty acid oxidation (FAOxn) stimulation at 200 nM. Uses: Enzyme inhibitors. Synonyms: ND 630; ND630; NDI-010976; NDI 010976; NDI010976; GS-0976; GS0976; GS 0976; Firsocostat; Thieno[2,3-d]pyrimidine-3(2H)-acetic acid, 1,4-dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxo-; 1,4-Dihydro-1-[(2R)-2-(2-methoxyphenyl)-2-[(tetrahydro-2H-pyran-4-yl)oxy]ethyl]-α,α,5-trimethyl-6-(2-oxazolyl)-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetic acid; (R)-2-(1-(2-(2-Methoxyphenyl)-2-((tetrahydro-2H-pyran-4-yl)oxy)ethyl)-5-methyl-6-(oxazol-2-yl)-2,4-dioxo-1,2-dihydrothieno[2,3-d]pyrimidin-3(4H)-yl)-2-methylpropanoic acid; 2-[1-{(2R)-2-(2-methoxyphenyl)-2-[(oxan-4-yl)oxy]ethyl}-5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxo-1,4-dihydrothieno[2,3-d]pyrimidin-3(2H)-yl]-2-methylpropanoic acid; GS-ACC; GS-Y. Grades: ≥95%. CAS No. 1434635-54-7. Molecular formula: C28H31N3O8S. Mole weight: 569.63. |  |
| ND-630 S enantiomer | ND-630 S enantiomer is the S enantiomer of ND-630 which is an acetyl-CoA carboxylase (ACC) inhibitor, and improves metabolic syndrome endpoints, decreases liver steatosis, decreases expression of inflammatory markers and improves fibrosis. Synonyms: 2-[1-[(2S)-2-(2-methoxyphenyl)-2-(oxan-4-yloxy)ethyl]-5-methyl-6-(1,3-oxazol-2-yl)-2,4-dioxothieno[2,3-d]pyrimidin-3-yl]-2-methylpropanoic acid; ND-630 (S enantiomer); ND 630 (S enantiomer); ND630 (S enantiomer). Molecular formula: C28H31N3O8S. Mole weight: 569.63. | |
| Firsocostat | Firsocostat (ND-630; GS-0976; NDI-010976) is an acetyl-CoA carboxylase ( ACC ) inhibitor; inhibits human ACC1 and ACC2 with IC 50 values of 2.1 and 6.1 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ND-630; GS-0976; NDI-010976. CAS No. 1434635-54-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16901. |  |
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