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| Product | Description | |
|---|---|---|
| Neamine | Neamine, also known as Neomycin A, is a broad-spectrum aminoglycoside antibiotic derived from the neomycin complex produced by the actinomycete S. fradiae. It is a degradation product of neomycin and has potent antibacterial, antitumor, and neuroprotective activities. Neamine is an anti-angiogenesis agent that targets angiogenin and has been shown to inhibit ANG-mediated AsPC-1 cell proliferation in a dose-dependent manner in vitro. In vivo, Neamine has demonstrated anti-tumor effects on AsPC-1 xenograft models, reducing the expression levels of ANG, Ki-67, and CD31 in tumor xenografts. Synonyms: Neomycin Sulfate EP Impurity A; 2-Deoxy-4-O-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)-D-streptamine; Framycetin Sulfate EP Impurity A; Neomycin B sulfate EP Impurity A; Negamicin; Dekamycin V; Neomycin A; 4-O-(2,6-Diamino-2,6-dideoxy-alpha-D-glucopyranosyl)-2-deoxy-D-streptamine; (+)-Neamine; Neamin; Nebramycin X; O-2,6-Diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)-1,3-diamino-1,2,3-trideoxy-D-myo-inositol; ST 7 (neomycin A); Neomycin Impurity A. Grade: >95%. CAS No. 3947-65-7. Molecular formula: C12H26N4O6. Mole weight: 322.36. |  |
| neamine phosphoribosyltransferase | Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including ribostamycin, neomycin and butirosin. The enzyme requires a divalent metal ion, optimally Mg2+, Ni2+ or Co2+. Group: Enzymes. Synonyms: btrL (gene name); neoM (gene name). Enzyme Commission Number: EC 2.4.2.49. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2678; neamine phosphoribosyltransferase; EC 2.4.2.49; btrL (gene name); neoM (gene name). Cat No: EXWM-2678. |  |
| Neamine tetrahydrochloride | Neamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting angiogenin. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 15446-43-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-115349. |  |
| neamine transaminase | The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin B, butirosin, neomycin and ribostamycin. Works in combination with EC 1.1.3.43, paromamine 6-oxidase, to replace the 6'-hydroxy group of paromamine with an amino group. The enzyme from the bacterium Streptomyces kanamyceticus can also catalyse EC 2.6.1.94, 2'-deamino-2'-hydroxyneamine transaminase, which leads to production of kanamycin A. The enzyme from the bacterium Streptomyces fradiae can also catalyse EC 2.6.1.95, leading to production of neomycin C. Group: Enzymes. Synonyms: glutamate-6'-dehydroparomamine aminotransferase; btrB (gene name); neoN (gene name); kacL (gene name). Enzyme Commission Number: EC 2.6.1.93. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2934; neamine transaminase; EC 2.6.1.93; glutamate-6'-dehydroparomamine aminotransferase; btrB (gene name); neoN (gene name); kacL (gene name). Cat No: EXWM-2934. | |
| 2'-deamino-2'-hydroxyneamine transaminase | The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathway of kanamycin A and kanamycin D. The enzyme, characterized from the bacterium Streptomyces kanamyceticus, can also catalyse EC 2.6.1.93, neamine transaminase. Group: Enzymes. Synonyms: kacL (gene name). Enzyme Commission Number: EC 2.6.1.94. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2935; 2'-deamino-2'-hydroxyneamine transaminase; EC 2.6.1.94; kacL (gene name). Cat No: EXWM-2935. | |
| kanamycin kinase | Also acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A. An enzyme from Pseudomonas aeruginosa also acts on butirosin. Group: Enzymes. Synonyms: neomycin-kanamycin phosphotransferase. Enzyme Commission Number: EC 2.7.1.95. CAS No. 62213-36-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3125; kanamycin kinase; EC 2.7.1.95; 62213-36-9; neomycin-kanamycin phosphotransferase. Cat No: EXWM-3125. | |
| neomycin C transaminase | The reaction occurs in vivo in the opposite direction. Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. Works in combination with EC 1.1.3.44, 6'''-hydroxyneomycin C oxidase, to replace the 6'''-hydroxy group of 6'''-deamino-6'''-hydroxyneomycin C with an amino group.The enzyme, characterized from the bacterium Streptomyces fradiae, can also catalyse EC 2.6.1.93, neamine transaminase. Group: Enzymes. Synonyms: neoN (gene name). Enzyme Commission Number: EC 2.6.1.95. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2936; neomycin C transaminase; EC 2.6.1.95; neoN (gene name). Cat No: EXWM-2936. | |
| paromamine 6'-oxidase | Contains FAD. Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin. Works in combination with EC 2.6.1.93, neamine transaminase, to replace the 6'-hydroxy group of paromamine with an amino group. The enzyme from the bacterium Streptomyces fradiae also catalyses EC 1.1.3.44, 6'''-hydroxyneomycin C oxidase. Group: Enzymes. Synonyms: btrQ (gene name); neoG (gene name); kanI (gene name); tacB (gene name); neoQ (obsolete gene name). Enzyme Commission Number: EC 1.1.3.43. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0416; paromamine 6'-oxidase; EC 1.1.3.43; btrQ (gene name); neoG (gene name); kanI (gene name); tacB (gene name); neoQ (obsolete gene name). Cat No: EXWM-0416. | |
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