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| Product | Description | |
|---|---|---|
| Nebentan | Nebentan, also known as YM598, is an orally active synthetic substituted phenylethenesulfonamide. As a selective endothelin A receptor antagonist, YM598 inhibits endothelin-mediated mechanisms involved in tumor cell growth and progression, angiogenesis, and metastasis. Synonyms: YM598 free base; Ethenesulfonamide, N-[6-methoxy-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-2-phenyl-, (1E)-; (E)-N-[6-Methoxy-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]-2-phenylethenesulfonamide. Grades: ≥95%. CAS No. 403604-85-3. Molecular formula: C24H21N5O5S. Mole weight: 491.52. |  |
| Nebentan potassium | Nebentan potassium (YM598) is a potent, selective and orally active non-peptide endothelin ET A receptor antagonist through the modification of Bosentan (HY-A0013). Nebentan potassium inhibits [ 125 I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with K i of 0.697 nM and 569 nM, respectively [1]. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: YM598. CAS No. 342005-82-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106994A. |  |
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