Necrostatin Suppliers USA
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Product | Description | |
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Necrostatin-1 Quick inquiry Where to buy Suppliers range | Competitive indoleamine 2,3-dioxygenase (IDO) inhibitor. Cell permeable, potent and selective necroptosis (a non-apoptotic form of programmed cell death) inhibitor. Showed neuroprotection in a murine model of ischemic brain injury in vivo. Selective and ATP-competitive receptor-interacting protein kinase 1 (RIPK1) inhibitor. Used in inflammatory and degenerative disease models to target RIPK1. Suppresses autophagy and apoptosis in murine brain injury models. Group: Biochemicals. Alternative Names: Nec-1, MTH-Trp, MTH-DL-Tryptophan, Methyl-thiohydantoin DL-tryptophan, 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone. Grades: Highly Purified. CAS No. 4311-88-0. Pack Sizes: 5mg, 25mg. Molecular Formula: C??H??N?OS. US Biological Life Sciences. | Worldwide |
Necrostatin-1 Quick inquiry Where to buy Suppliers range | Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM. Synonyms: Necrostatin-1; Necrostatin1; Necrostatin 1; Nec-1; Nec 1; Nec1. Grades: >98%. CAS No. 4311-88-0. Molecular formula: C13H13N3OS. Mole weight: 259.33. | |
Necrostatin-1 (5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone, Methylthiohydantoin-DL-tryptophan, Nec-1) Quick inquiry Where to buy Suppliers range | Inhibits necroptosis, a non-apoptotic cell death pathway. Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. Inhibits RIP1 kinase, the key upstream kinase involved in the activation of necroptosis (EC50 = 180nM). Group: Biochemicals. Alternative Names: 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone; 5-(Indol-3-ylmethyl)-3-methyl-2-thiohydantoin; Nec 1. Grades: Highly Purified. CAS No. 4311-88-0. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
Necrostatin-1 Inactive Control Quick inquiry Where to buy Suppliers range | Necrostatin-1 Inactive Control (Nec-1i) is a cell-permeable demethylated analog of necrostatin-1 (Nec-1), an RIP1 kinase inhibitor. Synonyms: Nec-1i; 5-(Indol-3-ylmethyl)-2-thiohydantoin. Grades: ≥98%. CAS No. 64419-92-7. Molecular formula: C12H11N3OS. Mole weight: 245.3. | |
Necrostatin 2 Quick inquiry Where to buy Suppliers range | Necrostatin 2 is a potent necroptosis inhibitor. It is a potent in vitro necroptosis inhibitors and is also efficacious in an animal model of ischemic stroke. Synonyms: Necrostatin 2; Necrostatin-2; Necrostatin2; Nec-2; Nec 2; Nec2; 2,4-Imidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-, (5R)-. Grades: >98%. CAS No. 852391-19-6. Molecular formula: C13H12ClN3O2. Mole weight: 277.71. | |
Necrostatin 2 racemate Quick inquiry Where to buy Suppliers range | Necrostatin 2 racemate is the racemate of Necrostatin, which is a potent necroptosis inhibitor. Grades: >98%. CAS No. 852391-15-2. Molecular formula: C13H12ClN3O2. Mole weight: 277.71. | |
Necrostatin 2 S enantiomer Quick inquiry Where to buy Suppliers range | Necrostatin 2 S enantiomer is the S enantiomer of Necrostatin, which is a potent necroptosis inhibitor. Synonyms: Necrostatin 2 S enantiomer; 852391-20-9; Necrostatin 2 (S enantiomer); Necrostatin 2 S-Enantiomer; (5S)-5-[(7-CHLORO-1H-INDOL-3-YL)METHYL]-3-METHYLIMIDAZOLIDINE-2,4-DIONE; (S)-5-((7-chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione; SCHEMBL859928; CHEMBL365607; CJB39120; HY-14622B; AKOS030526930; CS-1665; 2,4-Imidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-, (5S)-; NCGC00390744-01; MS-23944; F84976; A917559. Grades: >98%. CAS No. 852391-20-9. Molecular formula: C13H12ClN3O2. Mole weight: 277.71. | |
Necrostatin-5 Quick inquiry Where to buy Suppliers range | Necrostatin-5 is a selective allosteric inhibitor of RIP1 kinase, an enzyme responsible for necroptosis. Synonyms: Nec-5; 2-[[3,4,5,6,7,8-hexahydro-3-(4-methoxyphenyl)-4-oxo[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]-acetonitrile; 3-p-methoxyphenyl-5,6-tetramethylenothieno[2,3-d]pyrimidin-4-one-2-mercaptoethylcyanide. Grades: ≥98%. CAS No. 337349-54-9. Molecular formula: C19H17N3O2S2. Mole weight: 383.5. | |
Necrostatin-5 (Nec-5, 3-p-Methoxyphenyl-5, 6-tetramethylenothieno [2, 3-d]pyrimidin-4-one-2-mercaptoethylcyanide) Quick inquiry Where to buy Suppliers range | Inhibits non-apoptotic cell death pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved in necroptosis, the alternative active cell death pathway: T-loop dependent inhibition by necrostatin-1; partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5. Group: Biochemicals. Alternative Names: 3-p-Methoxyphenyl-5, 6-tetramethylenothieno [2, 3-d]pyrimidin-4-one-2-mercaptoethylcyanide) . Grades: Highly Purified. CAS No. 337349-54-9. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
Necrostatin-5 (Nec-5, 3-p-Methoxyphenyl-5, 6-tetra methyl enothienopyrimidin-4-one-2-mercaptoethylcyanide) Quick inquiry Where to buy Suppliers range | Necroptosis inhibitor. Indirect RIP1 kinase inhibitor. Group: Biochemicals. Alternative Names: Nec-5, 3-p-Methoxyphenyl-5, 6-tetra methyl enothienopyrimidin-4-one-2-mercaptoethylcyanide. Grades: Highly Purified. CAS No. 337349-54-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Necrostatin-7 (Nec-7) Quick inquiry Where to buy Suppliers range | Necroptosis inhibitor. Does not inhibit RIP1 kinase. Group: Biochemicals. Alternative Names: Nec-7. Grades: Highly Purified. CAS No. 351062-08-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Necrostatin-7 ((Z)-5-((3-(4-Fluorophenyl)-1H-pyrazol-4-yl)methylene)-2-imino-3-(thiazol-2-yl)thiazolidin-4-one, Nec-7) Quick inquiry Where to buy Suppliers range | A necroptosis inhibitor. The biological activity of necrostatin-7 (Nec-7) is different from that of necrostatin-1 to -5 as Nec-7 does not inhibit RIP1 kinase. Nec-7 may target an additional regulatory molecule in the pathway. Group: Biochemicals. Alternative Names: (Z)-5-((3-(4-Fluorophenyl)-1H-pyrazol-4-yl)methylene)-2-imino-3-(thiazol-2-yl)thiazolidin-4-one, Nec-7. Grades: Highly Purified. CAS No. 351062-08-3. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |