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| Product | Description | |
|---|---|---|
| Necrostatin-1 | Competitive indoleamine 2,3-dioxygenase (IDO) inhibitor. Cell permeable, potent and selective necroptosis (a non-apoptotic form of programmed cell death) inhibitor. Showed neuroprotection in a murine model of ischemic brain injury in vivo. Selective and ATP-competitive receptor-interacting protein kinase 1 (RIPK1) inhibitor. Used in inflammatory and degenerative disease models to target RIPK1. Suppresses autophagy and apoptosis in murine brain injury models. Group: Biochemicals. Alternative Names: Nec-1, MTH-Trp, MTH-DL-Tryptophan, Methyl-thiohydantoin DL-tryptophan, 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone. Grades: Highly Purified. CAS No. 4311-88-0. Pack Sizes: 5mg, 25mg. Molecular Formula: C??H??N?OS. US Biological Life Sciences. |  Worldwide |
| Necrostatin-1 | Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM. Synonyms: Necrostatin-1; Necrostatin1; Necrostatin 1; Nec-1; Nec 1; Nec1. Grades: >98%. CAS No. 4311-88-0. Molecular formula: C13H13N3OS. Mole weight: 259.33. |  |
| Necrostatin-1 | Necrostatin-1 (Nec-1) is a potent and cross the blood-brain barrier necroptosis inhibitor with an EC 50 of 490 nM in Jurkat cells. Necrostatin-1 inhibits RIP1 kinase ( EC 50 =182 nM). Necrostatin-1 is also an IDO inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Nec-1. CAS No. 4311-88-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15760. |  |
| Necrostatin-1 (5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone, Methylthiohydantoin-DL-tryptophan, Nec-1) | Inhibits necroptosis, a non-apoptotic cell death pathway. Does not inhibit FAS-induced apoptosis and has no effect on apoptotic morphology. Inhibits RIP1 kinase, the key upstream kinase involved in the activation of necroptosis (EC50 = 180nM). Group: Biochemicals. Alternative Names: 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone; 5-(Indol-3-ylmethyl)-3-methyl-2-thiohydantoin; Nec 1. Grades: Highly Purified. CAS No. 4311-88-0. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Necrostatin-1 (inactive control) | Necrostatin-1 (Nec-1) (inactive control) is an inactive analog of Necrostatin-1 (HY-15760). Necrostatin-1 is a potent necroptosis inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Nec-1 (inactive control). CAS No. 64419-92-7. Pack Sizes: 1 mg. Product ID: HY-121954. | |
| Necrostatin-1 Inactive Control | Necrostatin-1 Inactive Control (Nec-1i) is a cell-permeable demethylated analog of necrostatin-1 (Nec-1), an RIP1 kinase inhibitor. Synonyms: Nec-1i; 5-(Indol-3-ylmethyl)-2-thiohydantoin. Grades: ≥98%. CAS No. 64419-92-7. Molecular formula: C12H11N3OS. Mole weight: 245.3. | |
| Necrostatin 2 | Necrostatin 2 is a potent necroptosis inhibitor. EC 50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM. Necrostatin 2 is also a RIPK1 inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 852391-19-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-14622. | |
| Necrostatin 2 | Necrostatin 2 is a potent necroptosis inhibitor. It is a potent in vitro necroptosis inhibitors and is also efficacious in an animal model of ischemic stroke. Synonyms: Necrostatin 2; Necrostatin-2; Necrostatin2; Nec-2; Nec 2; Nec2; 2,4-Imidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-, (5R)-. Grades: >98%. CAS No. 852391-19-6. Molecular formula: C13H12ClN3O2. Mole weight: 277.71. | |
| Necrostatin 2 racemate | Necrostatin 2 racemate is the racemate of Necrostatin, which is a potent necroptosis inhibitor. Grades: >98%. CAS No. 852391-15-2. Molecular formula: C13H12ClN3O2. Mole weight: 277.71. | |
| Necrostatin 2 racemate | Necrostatin 2 racemate (Nec-1S), the Necrostatin-1 (HY-15760) stable, is a potent and specific RIPK1 inhibitor lacking the IDO-targeting effect [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Necrostatin 1S; Nec-1S; 7-Cl-O-Nec1. CAS No. 852391-15-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-14622A. | |
| Necrostatin 2 S enantiomer | Necrostatin 2 S enantiomer is the S enantiomer of Necrostatin, which is a potent necroptosis inhibitor. Synonyms: Necrostatin 2 S enantiomer; 852391-20-9; Necrostatin 2 (S enantiomer); Necrostatin 2 S-Enantiomer; (5S)-5-[(7-CHLORO-1H-INDOL-3-YL)METHYL]-3-METHYLIMIDAZOLIDINE-2,4-DIONE; (S)-5-((7-chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione; SCHEMBL859928; CHEMBL365607; CJB39120; HY-14622B; AKOS030526930; CS-1665; 2,4-Imidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-, (5S)-; NCGC00390744-01; MS-23944; F84976; A917559. Grades: >98%. CAS No. 852391-20-9. Molecular formula: C13H12ClN3O2. Mole weight: 277.71. | |
| Necrostatin-5 | Necrostatin-5 is a selective allosteric inhibitor of RIP1 kinase, an enzyme responsible for necroptosis. Synonyms: Nec-5; 2-[[3,4,5,6,7,8-hexahydro-3-(4-methoxyphenyl)-4-oxo[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]-acetonitrile; 3-p-methoxyphenyl-5,6-tetramethylenothieno[2,3-d]pyrimidin-4-one-2-mercaptoethylcyanide. Grades: ≥98%. CAS No. 337349-54-9. Molecular formula: C19H17N3O2S2. Mole weight: 383.5. | |
| Necrostatin-5 | Necrostatin-5 (Nec-5) is a potent necroptosis inhibitor with an EC50 value of 0.24 μM. Necrostatin-5 also is a RIP1 inhibitor. Necrostatin-5 shows cardioprotective effects. Group: Inhibitors. CAS No. 337349-54-9. Molecular formula: C19H17N3O2S2. Mole weight: 383.49. Purity: 0.9843. Catalog: ACM337349549. |  |
| Necrostatin-5 (Nec-5, 3-p-Methoxyphenyl-5, 6-tetramethylenothieno [2, 3-d]pyrimidin-4-one-2-mercaptoethylcyanide) | Inhibits non-apoptotic cell death pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved in necroptosis, the alternative active cell death pathway: T-loop dependent inhibition by necrostatin-1; partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5. Group: Biochemicals. Alternative Names: 3-p-Methoxyphenyl-5, 6-tetramethylenothieno [2, 3-d]pyrimidin-4-one-2-mercaptoethylcyanide) . Grades: Highly Purified. CAS No. 337349-54-9. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Necrostatin-5 (Nec-5, 3-p-Methoxyphenyl-5, 6-tetra methyl enothienopyrimidin-4-one-2-mercaptoethylcyanide) | Necroptosis inhibitor. Indirect RIP1 kinase inhibitor. Group: Biochemicals. Alternative Names: Nec-5, 3-p-Methoxyphenyl-5, 6-tetra methyl enothienopyrimidin-4-one-2-mercaptoethylcyanide. Grades: Highly Purified. CAS No. 337349-54-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Necrostatin-7 | Necrotatin-7 (Nec-7) is a potent necroptosis inhibitor with an EC 50 of 10.6 μM. Necrotatin-7 does not inhibit recombinant RIP1 kinase [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Nec-7. CAS No. 351062-08-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117200. | |
| Necrostatin-7 | Necrotatin-7 (Nec-7) is a potent necroptosis inhibitor with an EC50 of 10.6 μM. Necrotatin-7 does not inhibit recombinant RIP1 kinase. Group: Inhibitors. Alternative Names: STK763743, necrotatin-7, Necrostatin-7, AC1LOGUN, Nec-7, CHEMBL514242, HMS621M06, MolPort-002-708-930, ZINC20587175, AKOS001738191, A2363/0099838, 5-[3-(4-Fluoro-phenyl)-1H-pyrazol-4-ylmethylene]-2-imino-[2,3]bithiazolyl-4-one, (5Z)-5-[[5-(4-fluorophenyl)-1H-pyrazol-4-yl]methylidene]-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one, (5Z)-5-{[3-(4-fluorophenyl)-1H-pyrazol-4-yl]methylidene}-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one, 351062-08-3, 5-[[3-(4-Fluorophenyl)-1H-pyrazol-4-yl]methylene]-2-imino-3-(2-thiazolyl)-4-thiazolidinone. CAS No. 351062-08-3. Molecular formula: C16H10FN5OS2. Mole weight: 371.41. Appearance: Solid. Purity: 0.96. IUPACName: (5Z)-5-[[5-(4-fluorophenyl)-1H-pyrazol-4-yl]methylidene]-2-imino-3-(1,3-thiazol-2-yl)-1,3-thiazolidin-4-one. Canonical SMILES: C1=CC (=CC=C1C2=C (C=NN2)C=C3C (=O)N (C (=N)S3)C4=NC=CS4)F. Catalog: ACM351062083. | |
| Necrostatin-7 (Nec-7) | Necroptosis inhibitor. Does not inhibit RIP1 kinase. Group: Biochemicals. Alternative Names: Nec-7. Grades: Highly Purified. CAS No. 351062-08-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Necrostatin-7 ((Z)-5-((3-(4-Fluorophenyl)-1H-pyrazol-4-yl)methylene)-2-imino-3-(thiazol-2-yl)thiazolidin-4-one, Nec-7) | A necroptosis inhibitor. The biological activity of necrostatin-7 (Nec-7) is different from that of necrostatin-1 to -5 as Nec-7 does not inhibit RIP1 kinase. Nec-7 may target an additional regulatory molecule in the pathway. Group: Biochemicals. Alternative Names: (Z)-5-((3-(4-Fluorophenyl)-1H-pyrazol-4-yl)methylene)-2-imino-3-(thiazol-2-yl)thiazolidin-4-one, Nec-7. Grades: Highly Purified. CAS No. 351062-08-3. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Necroptosis-IN-1 | Necroptosis-IN-1, an analog of Necrostatin-1, is a potent necroptosis inhibitor. Necroptosis-IN-1 is a RIPK inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1391980-92-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-135826. | |
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