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| Product | Description | |
|---|---|---|
| Neratinib | Neratinib, also known as HKI-272 or PB272, is an orally available, 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Treatment of cells with this agent results in inhibition of downstream signal transduction events and cell cycle regulatory pathways; arrest at the G1-S (Gap 1/DNA synthesis)-phase transition of the cell division cycle; and ultimately decreased cellular proliferation. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells. Alternative Names: HKI-272. Neratinib (HKI-272). Nerlynx. CAS No. 698387-09-6. Product ID: API698387096. Molecular formula: C30H29ClN6O3. Mole weight: 557. EINECS: 811-237-1. SMILES: CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)/C=C/CN(C)C. Appearance: Solid powder. Category: Anti-Tumor APIs. |  |
| Neratinib | Neratinib. Group: Biochemicals. Alternative Names: (2E) -N-[4-[[3-Chloro-4- (2-pyridinylmethoxy) phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4- (dimethylamino) -2-butenamide; HKI 272. Grades: Highly Purified. CAS No. 698387-09-6. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Neratinib | Neratinib (HKI-272) is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC 50 s of 59 nM and 92 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HKI-272. CAS No. 698387-09-6. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-32721. |  |
| Neratinib Impurity 33 | Neratinib Impurity 33. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1222172-49-7. Molecular formula: C12H16N2O4. Mole weight: 252.27. Catalog: APB1222172497. |  |
| Neratinib Impurity 34 | Neratinib Impurity 34. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1222172-50-0. Molecular formula: C15H17N3O4. Mole weight: 303.32. Catalog: APB1222172500. | |
| Neratinib Impurity 6 | Neratinib Impurity 6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 102137-46-2. Molecular formula: C12H12N2O. Mole weight: 200.24. Catalog: APB102137462. | |
| Neratinib Impurity 8 | Neratinib Impurity 8. Uses: For analytical and research use. Group: Impurity standards. CAS No. 105326-69-0. Molecular formula: C12H11ClN2O. Mole weight: 234.68. Catalog: APB105326690. | |
| Neratinib maleate | Neratinib (HKI-272) maleate is an orally available, irreversible, highly selective HER2 and EGFR inhibitor with IC 50 s of 59 nM and 92 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HKI-272 maleate. CAS No. 915942-22-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-32721B. | |
| Neratinib Maleate | Neratinib Maleate is the maleate salt form of neratinib, an orally available, quinazoline-based, irreversible inhibitor of both the receptor tyrosine kinases (RTKs) human epidermal growth factor receptor 2 (HER2; ERBB2) and human epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Alternative Names: hki-272 maleate. Nerlynx. Neratinib maleate [MI]. CAS No. 915942-22-2. Product ID: API915942222. Molecular formula: C34H33ClN6O7. Mole weight: 673.1. EINECS: 620-527-5. SMILES: CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C.C(=CC(=O)O)C(=O)O. Category: Anti-Tumor APIs. | |
| 2-[[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]amino]-2-oxoacetic acid | An impurity of Neratinib, which is an irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: Neratinib Impurity AJCS. Grade: ≥95%. CAS No. 1144516-13-1. Molecular formula: C26H20ClN5O5. Mole weight: 517.92. |  |
| 2-[(4-Aminophenoxy)methyl]pyridine | An impurity of Neratinib, which is irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: Neratinib Impurity SMQL; 4-(Pyridin-2-ylmethoxy)-phenylamine. Grade: 95%. CAS No. 102137-46-2. Molecular formula: C12H12N2O. Mole weight: 200.24. | |
| (2E)-N-?(4-?Chloro-?3-?cyano-?7-?ethoxy-?6-?quinolinyl)?-?2-butenamide | (2E)-N-?(4-?Chloro-?3-?cyano-?7-?ethoxy-?6-?quinolinyl)?-?2-butenamide was used to prepare Neratinib and intermediates thereof. Group: Biochemicals. Grades: Highly Purified. CAS No. 1403831-79-7. Pack Sizes: 25mg, 100mg. Molecular Formula: C16H14ClN3O2, Molecular Weight: 315.75. US Biological Life Sciences. | Worldwide |
| 3-Chloro-4-(pyridin-3-ylmethoxy)aniline | An impurity of Neratinib, which is an irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: 3-chloro-4-(pyridin-3-ylmethoxy)phenylamine; Benzenamine, 3-chloro-4-(3-pyridinylmethoxy)-. Grade: ≥95%. CAS No. 848134-24-7. Molecular formula: C12H11ClN2O. Mole weight: 234.68. | |
| 3-Chloro-4-(pyridin-4-ylmethoxy)-phenylamine | An impurity of Neratinib, which is an irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: Neratinib Impurity SMPBD. Grade: ≥95%. CAS No. 105326-69-0. Molecular formula: C12H11ClN2O. Mole weight: 234.68. | |
| 4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-7-ethoxy-6-[(1-methyl-2-pyrrolidinylidene)amino]-3-quinolinecarbonitrile | An impurity of Neratinib, which is an irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: Neratinib Impurity PRQ; 3-Quinolinecarbonitrile, 4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-7-ethoxy-6-[(1-methyl-2-pyrrolidinylidene)amino]-. Grade: ≥95%. CAS No. 1144516-21-1. Molecular formula: C29H27ClN6O2. Mole weight: 527.02. | |
| 4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxy-6-(2-hydroxy-5-oxopyrrolidin-1-yl)quinoline-3-carbonitrile | An impurity of Neratinib, which is an irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Synonyms: Quinoline-3-carbonitrile, 4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxy-6-(2-hydroxy-5-oxopyrrolidin-1-yl); Neratinib Impurity 14. Grade: ≥95%. CAS No. 1144516-15-3. Molecular formula: C28H24ClN5O4. Mole weight: 529.98. | |
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