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Neuromedin B (NMB), an endogenous activator for the neuromedin B receptor (NMBR), is a member of Bombesin (BN)-like peptide family in mammals. Synonyms: H-Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2; glycyl-L-asparagyl-L-leucyl-L-tryptophyl-L-alanyl-L-threonyl-glycyl-L-histidyl-L-phenylalanyl-L-methioninamide; Neuromedin B (porcine); [125I]-Bolton Hunter neuromedin B; [125I]BH-NMB (human, mouse, rat). Grades: ≥95%. CAS No. 87096-84-2. Molecular formula: C52H73N15O12S. Mole weight: 1132.29.
Neuromedin B
Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals. Uses: Scientific research. Group: Peptides. CAS No. 87096-84-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P0241.
Neuromedin C
Neuromedin C (NMC) is a decapeptide that acts as a growth factor in a variety of tumors. Synonyms: Neuromedin C (porcine); Gly-asn-his-trp-ala-val-gly-his-leu-met-NH2; GRP (18-27) (human, porcine, canine); Bombesin decapeptide; Grp-10; Gastrin releasing peptide 10; Canine gastrin-releasing peptide 10; Gastrin releasing peptide (18-27); glycyl-L-asparagyl-L-histidyl-L-tryptophyl-L-alanyl-L-valyl-glycyl-L-histidyl-L-leucyl-L-methioninamide. Grades: ≥95% by HPLC. CAS No. 81608-30-2. Molecular formula: C50H73N17O11S. Mole weight: 1120.29.
Neuromedin C (porcine)
Neuromedin C porcine (GRP, 18-27, porcine) is a bombesin-like neuropeptide that can be obtained from porcine spinal cord. Neuromedin C porcine exhibits a potent contractile activity on rat uterus in the characteristic manner of bombesin. Neuromedin C porcine has research potential for neurological-related diseases [1]. Uses: Scientific research. Group: Peptides. Alternative Names: GRP(18-27) (porcine). CAS No. 81608-30-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-103283.
Neuromedin N
Heterocyclic Organic Compound. CAS No. 102577-25-3. Catalog: ACM102577253.
Neuromedin N
Neuromedin N is an intricate peptide extensively investigated within the biomedical arena, offering profound insights into its multifaceted involvement in studying diverse neurological disorders. Acting upon distinct receptors both in the central nervous system and peripheral tissues, this product exhibits the potential to exert considerable impact on the modulation of neuronal activity. Synonyms: Neuromedin N; Lys-ile-pro-tyr-ile-leu; 102577-25-3; 92169-45-4; Lysyl-isoleucyl-prolyl-tyrosyl-isoleucyl-leucine; Neuromedin N (rat, mouse, porcine, canine); H-Lys-Ile-Pro-Tyr-Ile-Leu-OH; NmN-125; CHEMBL1558364; DTXSID20145280; HY-P0079; AKOS024456846; CS-5506; NCGC00167134-01; MS-31303; Q7002397; (2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid; (S)-2-((2S,3S)-2-((S)-2-((S)-1-((2S,3S)-2-((S)-2,6-diaminohexanamido)-3-methylpentanoyl)pyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanamido)-3-methylpentanamido)-4-methylpentanoic acid. Grades: 95%. CAS No. 102577-25-3. Molecular formula: C38H63N7O8. Mole weight: 745.9.
Neuromedin N
Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes. Uses: Scientific research. Group: Peptides. Alternative Names: Neuromedin N (rat, mouse, porcine, canine). CAS No. 92169-45-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-P0079.
Neuromedin N acetate
Neuromedin N acetate is a potent modulator of dopamine D2 receptor agonist which binds in rat neostriatal membranes. Synonyms: H-Lys-Ile-Pro-Tyr-Ile-Leu-OH.CH3CO2H; L-lysyl-L-isoleucyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine acetic acid; Canine neuromedin N acetate salt; Mouse neuromedin N acetate salt; Neuromedin N (dog) acetate salt; Neuromedin N (human) acetate salt; Neuromedin N (ox) acetate salt; Neuromedin N (rat) acetate salt; Porcine neuromedin N acetate salt; Neuromedin N (rat, mouse, porcine, canine) acetate. Grades: ≥95%. Molecular formula: C40H67N7O10. Mole weight: 806.02.
Neuromedin S (human)
Neuromedin S (NMS), a 33-amino acid neuropeptide originally isolated from the rat brain, is a neuromedin U (NMU) receptor as an endogenous ligand of two orphan G protein-coupled receptors FM-3/GPR66 and FM-4/TGR-1. hNMS-33 is specifically expressed in the suprachiasmatic nuclei (SCN) of the hypothalamus. NMS is involved in circadian rhythm regulation through autocrine and/or paracrine. Synonyms: NMS (human); H-Ile-Leu-Gln-Arg-Gly-Ser-Gly-Thr-Ala-Ala-Val-Asp-Phe-Thr-Lys-Lys-Asp-His-Thr-Ala-Thr-Trp-Gly-Arg-Pro-Phe-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2; hNMS-33. Grades: ≥95%. CAS No. 1138204-27-9. Molecular formula: C173H265N53O44. Mole weight: 3791.34.
Neuromedin S (rat)
Neuromedin S, a novel neuropeptide of 36 amino acids isolated from rat brain as an endogenous ligand for the orphan G protein-coupled receptors FM-3/GPR66 and FM-4/TGR-1, is a potent, endogenous neuromedin U receptor agonist (EC50 values are 65 and 91 pM at NMU1 and NMU2 respectively). Central NMS may exert a physiological antidiuretic action via vasopressin release. Synonyms: L-leucyl-L-prolyl-L-arginyl-L-leucyl-L-leucyl-L-histidyl-L-threonyl-L-α-aspartyl-L-seryl-L-arginyl-L-methionyl-L-alanyl-L-threonyl-L-isoleucyl-L-α-aspartyl-L-phenylalanyl-L-prolyl-L-lysyl-L-lysyl-L-α-aspartyl-L-prolyl-L-threonyl-L-threonyl-L-seryl-L-leucylglycyl-L-arginyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-arginyl-L-prolyl-L-arginyl-L-aspartamide, trifluoroacetate salt; Leu-Pro-Arg-Leu-Leu-His-Thr-Asp-Ser-Arg-Met-Ala-Thr-Ile-Asp-Phe-Pro-Lys-Lys-Asp-Pro-Thr-Thr-Ser-Leu-Gly-Arg-Pro-Phe-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2. CAS No. 843782-19-4. Molecular formula: C193H307N57O49S. Mole weight: 4241.97.
Neuromedin U-25 (human)
Neuromedin U-25 (NMU-25) is a 25-amino acid neuropeptide found in CNS of humans, demonstrated to drive smooth muscle contraction and regulate blood pressure. In vivo study has shown that it regulates feeding, vasoconstriction, nociception, and bone remodeling and contributes to obesity, cancer and septic shock. Synonyms: NMU-25 (human); H-Phe-Arg-Val-Asp-Glu-Glu-Phe-Gln-Ser-Pro-Phe-Ala-Ser-Gln-Ser-Arg-Gly-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2; L-Aspartamide, L-phenylalanyl-L-arginyl-L-valyl-L-α-aspartyl-L-α-glutamyl-L-α-glutamyl-L-phenylalanyl-L-glutaminyl-L-seryl-L-prolyl-L-phenylalanyl-L-alanyl-L-seryl-L-glutaminyl-L-seryl-L-arginylglycyl-L-tyrosyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-arginyl-L-prolyl-L-arginyl-. Grades: ≥98%. CAS No. 312306-89-1. Molecular formula: C141H203N41O38. Mole weight: 3080.37.
Neuromedin U-25 porcine
Neuromedin U-25, from porcine spinal cord, is a potent stimulator of the smooth muscle of the rat uterus, and affects blood pressure in rats and dogs. Neuromedin U-8 is the same as Neuromedin U-25. Synonyms: Neuromedin u 25 (swinespinal cord); H-Phe-Lys-Val-Asp-Glu-Glu-Phe-Gln-Gly-Pro-Ile-Val-Ser-Gln-Asn-Arg-Arg-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2; L-phenylalanyl-L-lysyl-L-valyl-L-alpha-aspartyl-L-alpha-glutamyl-L-alpha-glutamyl-L-phenylalanyl-L-glutaminyl-glycyl-L-prolyl-L-isoleucyl-L-valyl-L-seryl-L-glutaminyl-L-asparagyl-L-arginyl-L-arginyl-L-tyrosyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-arginyl-L-prolyl-L-arginyl-L-asparaginamide; Neuromedin U-25 (porcine); NMU-25. Grades: ≥95%. CAS No. 98395-76-7. Molecular formula: C144H217N43O37. Mole weight: 3142.53.
Neuromedin U-25 (porcine)
Neuromedin U-25 (porcine) is a uterus stimulating and hypertensive peptides [1]. Uses: Scientific research. Group: Peptides. CAS No. 98395-76-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4682.
Neuromedin (U8), porcine
Neuromedin (U8), porcine has potent agonist activity for neuromedin resceptors NMUR1 and NMUR2. Synonyms: Neuromedin U-8; L-tyrosyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-arginyl-L-prolyl-L-arginyl-L-asparaginamide; H-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2. Grades: 95% by HPLC. CAS No. 98395-75-6. Molecular formula: C54H78N16O10. Mole weight: 1111.30.
Neuromedin u(rat)
Heterocyclic Organic Compound. Alternative Names: NEUROMEDIN U (RAT);NMU-23 (RAT);NMU, RAT;YKVNEYQGPVAPSGGFFLFRPRN-NH2;TYR-LYS-VAL-ASN-GLU-TYR-GLN-GLY-PRO-VAL-ALA-PRO-SER-GLY-GLY-PHE-PHE-LEU-PHE-ARG-PRO-ARG-ASN-NH2;H-TYR-LYS-VAL-ASN-GLU-TYR-GLN-GLY-PRO-VAL-ALA-PRO-SER-GLY-GLY-PHE-PHE-LEU-PHE-ARG-PRO-ARG. CAS No. 117505-80-3. Molecular formula: C124H180N34O31. Mole weight: 2642.97. Catalog: ACM117505803.
Neuromedin U, rat
Neuromedin U, a structurally highly conserved neuropeptide, is ubiquitously distributed, with highest levels found in the gastrointestinal tract and pituitary. Neuromedin U regulates blood pressure, ion transport in the gut, mesenteric blood flow and adrenocortical function, and also decreases food intake and body weight, increases body temperature and heat production, and inhibits gastric acid secretion via the CRH system following central administration in vivo. Synonyms: Rat neuromedin U-23; H-Tyr-Lys-Val-Asn-Glu-Tyr-Gln-Gly-Pro-Val-Ala-Pro-Ser-Gly-Gly-Phe-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2; L-tyrosyl-L-lysyl-L-valyl-L-asparagyl-L-alpha-glutamyl-L-tyrosyl-L-glutaminyl-glycyl-L-prolyl-L-valyl-L-alanyl-L-prolyl-L-seryl-glycyl-glycyl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-arginyl-L-prolyl-L-arginyl-L-asparaginamide. Grades: ≥95%. CAS No. 117505-80-3. Molecular formula: C124H180N34O31. Mole weight: 2642.97.
Heterocyclic Organic Compound. Alternative Names: [SUCCINYL-ASP6,ME-PHE8] SUBSTANCE P;SUCCINYL-(ASP6,N-ME-PHE8)-SUBSTANCE P (6-11);[SUCCINYL-ASP6 N-ME-PHE8]-SUBSTANCE P (6-11) (SENKTIDE);[SUCCINYL-ASP6,N-ME-PHE8]-SUBSTANCE P, FRAGMENT 6-11;SUCCINYL-ASP-PHE-ME-PHE-GLY-LEU-MET-NH2;SUCCINYL-ASP-PHE-(N-ME)P. CAS No. 106128-89-6. Molecular formula: C40H55N7O11S. Mole weight: 841.97. Appearance: White powder. Purity: 0.96. IUPACName: (3S)-4-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]amino]-3-[(4-hydroxy-4-oxobutanoyl)amino]-4-o. Density: 1.29 g/cm³. Catalog: ACM106128896.
3-Chloro-2-fluorobenzaldehyde
3-Chloro-2-fluorobenzaldehyde is an intermediate used to synthesize small-molecule inhibitors of MDM2-p53 interaction as antitumor agents. It is also used to prepare flavonoid derivatives as selective neuromedin U 2 receptor agonists for obesity treatment. Group: Biochemicals. Grades: Highly Purified. CAS No. 85070-48-0. Pack Sizes: 1g, 2.5g. Molecular Formula: C7H4ClFO, Molecular Weight: 158.56. US Biological Life Sciences.
Worldwide
3'-Methoxyflavonol
3'-Methoxyflavonol is a selective agonist of neuromedin U 2 receptor ( NMU2R ). Uses: Scientific research. Group: Natural products. CAS No. 76666-32-5. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-N6629.
BIM 23042 is a selective neuromedin B receptor (NMB-R, BB1) antagonist (Ki = 216 and 18, 264 nM for BB1 and BB2 receptors, respectively) displaying no effect on a range of other receptors. Synonyms: H-D-2-NAL-CYS-TYR-D-TRP-LYS-VAL-CYS-2-NAL-NH2; BIM 23042. CAS No. 111857-96-6. Molecular formula: C62H73N11O9S2. Mole weight: 1180.44.
JMV 390-1
JMV 390-1 has been found to be an inhibitor of the major neurotensin and neuromedin N degrading enzymes and could probably show analgesic activities. Synonyms: Jmv-390-1; Jmv390-1; N-[(2R)-4-Hydroxyamino)-1,4-dioxo-2-(phenylmethyl)butyl]-L-isoleucyl-L-leucine. Grades: ≥95% by HPLC. CAS No. 148473-36-3. Molecular formula: C23H35N3O6. Mole weight: 449.54.
JMV 449
JMV 449 could be a neurotensin receptor agonist peptide and has been found to show hypothermic and analgesic activities in the mouse. Synonyms: JMV-449; JMV449; (S)-1-de-L-lysine-2-[N2-(2,6-diaminohexyl)-L-lysine]-neuromedin N (pig spinal cord); H-Lysy(CH2NH)Lys-Pro-Tyr-Ile-Leu-OH. Grades: ≥95% by HPLC. CAS No. 139026-66-7. Molecular formula: C38H66N8O7. Mole weight: 746.96.
Neurokinin A
Neurokinin A is a member of the endogenous tachykinin agonist with preference for the NK-2R (NK-2 receptor). Synonyms: Neurokinin A; Substance K; Neuromedin L; H-D-His-D-Lys-Thr-Asp-D-Ser-Phe-D-Val-Gly-D-Leu-D-Met-NH2. Grades: ≥97% by HPLC. CAS No. 86933-74-6. Molecular formula: C50H80N14O14S. Mole weight: 1133.33.
Neurokinin A
Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Substance K; Neurokinin α; Neuromedin L. CAS No. 86933-74-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0197.
Neurokinin A TFA
Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Substance K TFA; Neurokinin α TFA; Neuromedin L TFA; NKA TFA. CAS No. 2828433-19-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P0197A.
Neurokinin B
Neurokinin B, one of the tachykinin family of peptides, binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R to mediate their biological effect but shows preference for the NK-3 receptor. Uses: Neurotransmitter agents. Synonyms: NKB; H-Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2; L-alpha-aspartyl-L-methionyl-L-histidyl-L-alpha-aspartyl-L-phenylalanyl-L-phenylalanyl-L-valyl-glycyl-L-leucyl-L-methioninamide; Neurokinin K; Neurokinin beta; β-Neurokinin; Neuromedin K; (5S,8S,14S,17S,20S,23S,26S,29S,32S)-26-((1H-imidazol-4-yl)methyl)-32-amino-17,20-dibenzyl-5-carbamoyl-23-(carboxymethyl)-8-isobutyl-14-isopropyl-29-(2-(methylthio)ethyl)-7,10,13,16,19,22,25,28,31-nonaoxo-2-thia-6,9,12,15,18,21,24,27,30-nonaazatetratriacontan-34-oic acid. Grades: ≥95%. CAS No. 86933-75-7. Molecular formula: C55H79N13O14S2. Mole weight: 1210.42.
Neurokinin B acetate
Neurokinin B acetate, one of the tachykinin family of peptides, binds a family of GPCRs-including neurokinin receptor 1 (NK1R), NK2R, and NK3R to mediate their biological effect but shows preference for the NK-3 receptor. Synonyms: H-Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2.CH3CO2H; L-alpha-aspartyl-L-methionyl-L-histidyl-L-alpha-aspartyl-L-phenylalanyl-L-phenylalanyl-L-valyl-glycyl-L-leucyl-L-methioninamide acetic acid; Neurokinin B (swine spinal cord) acetate; Neurokinin B (human) acetate; Neurokinin B (pig spinal cord) acetate; Neurokinin B (porcine) acetate; Neurokinin β (pig spinal cord) acetate; Neuromedin K (pig spinal cord) acetate; Porcine neurokinin B acetate; Zneurok1 (human) acetate. Grades: ≥95%. Molecular formula: C57H83N13O16S2. Mole weight: 1270.48.
PD 168368
PD 168368 is a competitive antagonist of neuromedin B (NMB) receptors. It blocks the elevation of intracellular calcium and release of inositol phosphate induced by NMB in cells expressing NMB receptors. Synonyms: (2S)-3-(1H-indol-3-yl)-2-methyl-2-[(4-nitrophenyl)carbamoylamino]-N-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide. Grades: ≥95%. CAS No. 204066-82-0. Molecular formula: C31H34N6O4. Mole weight: 554.6.
PD 176252
PD 176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively. PD 176252 inhibits proliferation of rat C6 glioma cells (IC50 = 2 μM) and inhibits NCI-H1299 xenograft proliferation in nude mice (IC50 = 5 μM). Synonyms: (S)-N-[[1-(5-Methoxy-2-pyridinyl)cyclohexyl]methyl]-α-methyl-α-[[[-(4-nitrophenyl)amino]carbonyl]amino-1H-indole-3-propanamide; PD-176252; PD 176252; PD176252. Grades: ≥98% by HPLC. CAS No. 204067-01-6. Molecular formula: C32H36N6O5. Mole weight: 584.67.
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