Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| Neutrophil Elastase Inhibitor | Neutrophil elastase inhibitor is an inhibitor that selectively targets the binding domain of neutrophil elastase, a serine proteinase secreted by neutrophils and macrophages during inflammation. It is potentially used for lung disease treatment. Uses: Protease inhibitors. Synonyms: 1-(3-Methylbenzoyl)-1H-indazole-3-carbonitrile. Grades: ≥95%. CAS No. 1448314-31-5. Molecular formula: C16H11N3O. Mole weight: 261.3. |  |
| Neutrophil elastase inhibitor 1 | Neutrophil elastase inhibitor 1 (Compound 5b) is a competitive, pseudoirreversible inhibitor for neutrophil elastase with an IC 50 of 7 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1448314-31-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-118177. |  |
| 1-Methyl-1H-indazole-6-carboxylic Acid Methyl Ester | 1-Methyl-1H-indazole-6-carboxylic Acid Methyl Ester is a useful synthetic intermediate. It is an analog of Indazole-3-carboxylic Acid Methyl Ester (I505250) which has potential as application of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase. Indazole-3-carboxylic Acid Methyl Ester (I505250) is also used in the preparation of indazole-pyridine based protain kinase/Akt inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1007219-73-9. Pack Sizes: 500mg, 5g. Molecular Formula: C10H10N2O2, Molecular Weight: 190.2. US Biological Life Sciences. |  Worldwide |
| 2-Methyl-2H-indazole-6-carboxylic Acid Methyl Ester | 2-Methyl-2H-indazole-6-carboxylic Acid Methyl Ester is a useful synthetic intermediate. It is an analog of Indazole-3-carboxylic Acid Methyl Ester (I505250) which has potential as application of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase. Indazole-3-carboxylic Acid Methyl Ester (I505250) is also used in the preparation of indazole-pyridine based protain kinase/Akt inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1071433-01-6. Pack Sizes: 500mg, 5g. Molecular Formula: C10H10N2O2, Molecular Weight: 190.2. US Biological Life Sciences. | Worldwide |
| Alvelestat | Alvelestat (AZD9668) is an orally bioavailable, affinity and selective inhibitor of neutrophil elastase (NE) with a pIC 50 value of 7.9 nM, a K i value of 9.4 nM and a K d value of 9.5 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD9668. CAS No. 848141-11-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15651. | |
| Alvelestat | Avelestat, also known as AZD9668, is a novel, oral inhibitor of neutrophil elastase (NE). Synonyms: AZD9668; AZD-9668; AZD 9668; MPH966; MPH 966; MPH-966; Alvelestat. Grades: 0.98. CAS No. 848141-11-7. Molecular formula: C25H22F3N5O4S. Mole weight: 545.537. | |
| BAY 677 | BAY 677 is an inactive control for BAY 678 and a human neutrophil elastase (HNE) inhibitor. Synonyms: BAY-677; BAY 677; BAY677; 5-[(4S)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile. Grades: ≥98% by HPLC. CAS No. 2117404-84-7. Molecular formula: C20H15F3N4O2. Mole weight: 400.35. | |
| BAY 678 | BAY 678 is a cell-permeable human neutrophil elastase (HNE) inhibitor (IC50 = 20 nM) that displays around 2000-fold selectivity for NHE over a panel of 21 other serine proteases. Synonyms: BAY 678; BAY678; BAY-678; 5-[(4R)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile. Grades: ≥98% by HPLC. CAS No. 675103-36-3. Molecular formula: C20H15F3N4O2. Mole weight: 400.35. | |
| BAY8040 | This active molecular is a Selective Human Neutrophil Elastase Inhibitor and combines excellent potency and selectivity with a promising pharmacokinetic profile. In animal models for pulmonary arterial hypertension, BAY8040 shows the efficancy of decreasing cardiac remodeling and amelioration of cardiac function in vivo. Uses: Cardiac remodeling and amelioration of cardiac function. Synonyms: BAY8040; BAY-8040; BAY 8040; (R)-4-(7-methyl-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4,5,6,7,8-octahydropyrimido[4,5-d]pyridazin-4-yl)benzonitrile. Grades: 98%. CAS No. 1194453-23-0. Molecular formula: C21H16F3N5O2. Mole weight: 427.39. | |
| BAY 85-8501 | This active molecular is a highly selective neutrophil elastase inhibitor.IC50 for HNE is 0.065 nM, LipE is 7.2. BAY 85-8501 was being tested in clinical studies for the treatment of pulmonary diseases. In Feb 2013, Phase-II clinical trials in Bronchiectasis in Spain were on going. In Mar 2013, Phase-II clinical trials in Bronchiectasis in France, Germany and Italy were on going. In Jun 2014, Bayer completed a phase IIa trial in Bronchiectasis in United Kingdom, Spain, France, Germany and Italy. Uses: The treatment of pulmonary diseases. Synonyms: BAY 85-8501; BAY85-8501; BAY-85-8501; BAY 858501; BAY858501; BAY-858501. (S)-4-(4-cyano-2-(methylsulfonyl)phenyl)-3,6-dimethyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydropyrimidine-5-carbonitrile. Grades: 98%. CAS No. 1161921-82-9. Molecular formula: C22H17F3N4O3S. Mole weight: 474.46. | |
| Elastase Inhibitor V (2-(2-Bromophenyl)-5-chloro-3,1-benzoxazin-4-one) | A benzoxazinone compound that acts as a potent inhibitor of human leukocyte elastase (IC50 = 29.5nM), likely by covalently modifying active site serine. Shown to inhibit elastase secretion (IC50 = 80.8nM), but not O2 - generation, in fLMP-stimulated primary human neutrophil cultures. Reported to reduce neutrophil infiltration in lung after hemorrhagic shock in rats in vivo (1mg/kg, i.v.). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| Freselestat | Freselestat is a high affinity and selective human neutrophil elastase 1 (HNE1) inhibitor (Ki = 12 nM) with >100-fold less activity at other related proteases including trypsin, pancreatic elastase, collagenase and murine macrophage elastase. Freselestat can be used as treatment for neutrophil-predominant inflammatory lung diseases. Synonyms: 2-(5-amino-6-oxo-2-phenylpyrimidin-1-yl)-N-[1-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-3-methyl-1-oxobutan-2-yl]acetamide; ONO6818; ONO 6818; ONO-6818. Grades: 95%. CAS No. 208848-19-5. Molecular formula: C23H28N6O4. Mole weight: 452.51. | |
| GW311616 | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor (IC50 value 22 nM). GW311616A is selective over other human serine proteases (IC50 values >100 μM for trypsin, cathepsin G, and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator), and does not inhibit AchE at 100 μM. Synonyms: GW-311616; GW 311616. Grades: >98%. CAS No. 198062-54-3. Molecular formula: C19H31N3O4S. Mole weight: 397.53. | |
| GW311616 hydrochloride | Potent, selective and orally active human neutrophil elastase (HNE) inhibitor (IC50 value 22 nM). GW311616A is selective over other human serine proteases (IC50 values >100 μM for trypsin, cathepsin G, and plasmin, >3 μM for chymotrypsin and tissue plasminogen activator), and does not inhibit AchE at 100 μM. Synonyms: GW-311616 hydrochloride; GW 311616 hydrochloride; GW311616A. Grades: >98%. CAS No. 197890-44-1. Molecular formula: C19H32ClN3O4S. Mole weight: 433.99. | |
| leukocyte elastase | Differs from pancreatic elastase in specificity on synthetic substrates and in inhibitor sensitivity. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.11. Group: Enzymes. Synonyms: lysosomal elastase; neutrophil elastase; polymorphonuclear leukocyte elastase; elastase; elaszym; serine elastase; lysosomal elastase; granulocyte elastase. Enzyme Commission Number: EC 3.4.21.37. CAS No. 9004-6-2. ELA2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4131; leukocyte elastase; EC 3.4.21.37; 9004-06-2; lysosomal elastase; neutrophil elastase; polymorphonuclear leukocyte elastase; elastase; elaszym; serine elastase; lysosomal elastase; granulocyte elastase. Cat No: EXWM-4131. |  |
| Lonodelestat | Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat (POL6014) has the potential for the research of cystic fibrosis (CF) [1] [2] [3]. Uses: Scientific research. Group: Peptides. Alternative Names: POL6014. CAS No. 906547-89-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P3293. | |
| Native Human α-1-Antitrypsin | Alpha-1 Antitrypsin or α1-antitrypsin (A1AT) is a protease inhibitor belonging to the serpin superfamily. It is generally known as serum trypsin inhibitor. Alpha 1-antitrypsin is also referred to as alpha-1 proteinase inhibitor (A1PI) because it inhibits a wide variety of proteases. It protects tissues from enzymes of inflammatory cells, especially neutrophil elastase, and has a reference range in blood of 1.5-3.5 gram/liter (in US the reference range is generally expressed as mg/dL or micromoles), but the concentration can rise manyfold upon acute inflammation. In its absence, neutrophil elastase is free to break down elastin, which contributes to the elasticity of the lungs, resulting in respiratory complications such as emphysema, or COPD (chronic obstructive pulmonary disease) in adults and cirrhosis in adults or children. Group: Enzymes. Synonyms: Alpha-1-Antitrypsin; A1AT; α1-antitrypsin; SERPINA1; A1A; A1AT; AAT; PI; PI1; PRO2275; alpha1AT. CAS No. 9041-92-3. Purity: > 95% (SDS-PAGE). A1AT. Mole weight: 54kDa. Storage: 2-8°C. Form: Lyophilized. Source: Human Plasma. Species: Human. Alpha-1-Antitrypsin; A1AT; α1-antitrypsin; SERPINA1; A1A; A1AT; AAT; PI; PI1; PRO2275; alpha1AT. Cat No: NATE-0010. | |
| ONO EI-601 | ONO EI-601, a sulfonylamine derivative, is one metabolite of ONO-5046 which is a neutrophil elastase inhibitor that could be effective against acute lung injury. Synonyms: Ono-EI-601; OnoEI601; Ono EI 601; Ono-EI 601; Ono EI-601; AC1MHG4J; N- (2- (p-Hydroxyphenylsulfonylamino) benzoyl) glycine; N- (2- ( ( (4-Hydroxyphenyl) sulfonyl) amino) benzoyl) glycine. Grades: 98%. CAS No. 155023-59-9. Molecular formula: C15H14N2O6S. Mole weight: 350.35. | |
| (R)-BAY-85-8501 | (R)-BAY-85-8501 is the less active Enantiomer of BAY-85-8501. BAY-85-8501 is a selective and potent inhibitor of Human Neutrophil Elastase (HNE) , with an IC 50 of 65 pM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2446175-39-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19908B. | |
| Sivelestat | Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nM, Ki=0.2 μM). It also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse (IC50 = 19 to 49 nM). However, it does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM. In in-vivo studies, it suppressed lung hemorrhage in hamster (ID50 = 82 μg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase. Synonyms: EI546; EI 546; EI-546; LY544349; LY 544349; LY-544349; ONO5046; ONO-5046; ONO 5046. Grades: >98%. CAS No. 127373-66-4. Molecular formula: C20H22N2O7S. Mole weight: 434.46. | |
| Sivelestat sodium | Sivelestat sodium(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse. Synonyms: Sivelestat sodium. Grades: >98%. CAS No. 150374-95-1. Molecular formula: C20H21N2NaO7S. Mole weight: 456.44. | |
| Sivelestat sodium tetrahydrate | Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nM, Ki=0.2 μM). It also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse (IC50 = 19 to 49 nM). However, it does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM. In in-vivo studies, it suppressed lung hemorrhage in hamster (ID50 = 82 μg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase. Uses: Serine proteinase inhibitors. Synonyms: EI546 sodium tetrahydrate; EI 546 sodium tetrahydrate; EI-546 sodium tetrahydrate; LY544349 sodium tetrahydrate; LY 544349 sodium tetrahydrate; LY-544349 sodium tetrahydrate; ONO5046 sodium tetrahydrate; ONO 5046 sodium tetrahydrate; ONO-5046 sodium tetrahydrate. Grades: >98%. CAS No. 201677-61-4. Molecular formula: C20H29N2NaO11S. Mole weight: 528.51. | |
| ZD8321 | ZD8321 is a potent inhibitor of human Neutrophil elastase (NE) (Ki= 13±1.7 nM), suppressing adhesion of neutrophils to TNFa-activated endothelial cells. That of cancer cells with high intracellular elastase activity was also suppressed by ZD8321. Synonyms: methyl N-[(2S)-3-methyl-1-oxo-1-[(2S)-2-[[(3S)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl]carbamoyl]pyrrolidin-1-yl]butan-2-yl]carbamate; 1-(2-methoxycarbonyl-3-methylbutyryl)-N-(2-methyl-1-(trifluoroacetyl)propyl)pyrrolidine-2-carboxamide; ZD 8321; ZD-8321. CAS No. 182073-77-4. Molecular formula: C18H28F3N3O5. Mole weight: 423.43. | |
| Z-Pro-OH | Z-Pro-OH. Uses: Z-pro-oh can be used: as a starting material to prepare aib-pro endothiopeptides of pharmacological importance. to prepare biologically significant fluorophore-labeled peptide tetramers or dimers. as a reactant to synthesize benzoxazole derived human neutrophil elastase (hne) inhibitors. Additional or Alternative Names: Z-L-Proline. Product Category: Amino Acids. CAS No. 1148-11-4. Mole weight: 249.26. Canonical SMILES: OC(=O)[C@@H]1CCCN1C(=O)OCc2ccccc2. ECNumber: 214-557-4. Product ID: ACM1148114. Alfa Chemistry ISO 9001:2015 Certified. Categories: N-Benzyloxycarbonyl-L-proline, Zero-ohm link. |  |
Our database is helping our users find suppliers everyday.
