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| Product | Description | |
|---|---|---|
| Nifurtimox | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopypharmacopoeial standards. |  |
| Nifurtimox | Antiprotozoal. Showing anti-Trypanosoma cruzi activity. Group: Biochemicals. Alternative Names: 3-Methyl-N-[(5-nitro-2-furanyl)methylene]-. Grades: Highly Purified. CAS No. 23256-30-6. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| Nifurtimox | Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi , has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase ( LDH ). Uses: Scientific research. Group: Signaling pathways. CAS No. 23256-30-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W040073. |  |
| Nifurtimox | Nifurtimox is a 5-nitrofuran and is used to treat diseases caused by trypanosomes including Chagas disease and sleeping sickness. It is given by mouth and not by injection. Nifurtimox is now in a Phase II clinical trial for the treatment of pediatric neuroblastoma and medulloblastoma. Nifurtimox decreased cell viability in a concentration-dependent manner. Nifurtimox also suppressed basal and TrkB-mediated Akt phosphorylation, and the cytotoxicity of nifurtimox was attenuated by a tyrosine hydroxylase inhibitor (alpha-methyl-tyrosine). Nifurtimox killed catecholaminergic, but not cholinergic, autonomic neurons in culture. In vivo xenograft models showed inhibition of tumor growth with a histologic decrease in proliferation and increase in apoptosis. These results suggest that nifurtimox induces cell death in neuroblastoma. Therefore, further studies are warranted to develop nifurtimox as a promising new treatment for neuroblastoma. Uses: Trypanocidal agents. Synonyms: BAY 2502; BAY2502; BAY-2502; Bayer 2502; Bayer2502; Bayer-2502; Lampit. Grades: >98%. CAS No. 23256-30-6. Molecular formula: C10H13N3O5S. Mole weight: 287.29. |  |
| RKS-262 | RKS262 is a specific cyclin/CDK inhibitor. RKS262 was identified by structural optimization of Nifurtimox which is currently undergoing phase II clinical trials to treat high-risk neuroblastoma. In a NCI(60) cell-line assay RKS262 exhibited significant cytotoxicity in ovarian cancer cells and a variety of other cell lines exceeding effects of commercial drugs such as cisplatin, 5-FU, cyclophosphamide or sapacitabine. Various leukemia cell-lines were most sensitive while several non-small cell lung cancer cell lines and few cell lines from other tissues were relatively resistant to RKS262 treatment. Synonyms: RKS-262; RKS 262; RKS-262. CAS No. 1041469-97-9. Molecular formula: C15H14BrClN2O4S. Mole weight: 433.70. | |
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