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| Product | Description | |
|---|---|---|
| Nigericin | 5mg Pack Size. Group: Antibiotics, Bioactive Small Molecules. Formula: C40H67NaO11. CAS No. 28380-24-7. Prepack ID 50435888-5mg. Molecular Weight 746.94. See USA prepack pricing. |  |
| Nigericin | Nigericin, derived from S. hygroscopicus, is an antibiotic potassium ionophore. It exchanges K+ for H+ across biological membranes. Nigericin can be a NLRP3 activator that induces the release of IL-1β as a NALP3-dependent manner. Nigericin triggers eryptosis, an effect paralleled by ROS formation, and in part due to induction of oxidative stress. Nigericin triggers apoptosis. Synonyms: 2-[6-[[2-[5-[5-[6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoic acid; Antibiotic K178; Antibiotic X464; Azalomycin M; Helexin C, Polyetherin A. Grades: >98%. CAS No. 28380-24-7. Molecular formula: C40H68O11. Mole weight: 724.96. |  |
| Nigericin | Nigericin Inhibitor. Uses: Scientific use. Product Category: T3092. CAS No. 28643-80-3. |  |
| Nigericin | Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K + /H + ionophore , promoting K + /H + exchange across mitochondrial membranes. Nigericin is a NLRP3 activator. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt / β-catenin signals. Nigericin induces pyroptosis through caspase 1 /GSDMD in TNBC [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Signaling pathways. CAS No. 28380-24-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-127019. |  |
| Nigericin sodium salt | ?98% (TLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Nigericin sodium salt | Antibiotic [1]. High affinity ionophore for monovalent cations such as H+, K+, Na+, Pb2+ [2, 3, 4, 7, 10]. Shows antibacterial (Gram-positive), antifungal, antitumor and antiviral activity [3, 6]. Disrupts membrane potential of mitochondria [2]. NLRP3/NALP3 activator. Signals through pannexin-1 to induce caspase-1 maturation and IL-1 β processing and release [5, 8, 11, 12]. Autophagy modulator [13]. Group: Biochemicals. Alternative Names: Antibiotic K 178; Helexin C; Polyetherin A; BRN 1696755; Azalomycin M; Antibiotic X-464. Grades: Highly Purified. CAS No. 28643-80-3. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. |  Worldwide |
| Nigericin sodium salt | Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that act as a K + /H + ionophore , promoting K + /H + exchange across mitochondrial membranes. Nigericin sodium salt is a NLRP3 activator. Nigericin sodium salt shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt / β-catenin signals. Nigericin sodium salt induces pyroptosis through caspase 1 /GSDMD in TNBC [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Natural products. CAS No. 28643-80-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100381. | |
| Nigericin sodium salt | Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore, a NLRP3 activator. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 28643-80-3. Molecular formula: C40H67NaO11. Mole weight: 746.94. Purity: Purity >98%. Product ID: ACM28643803. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Nigericin sodium salt Ready Made Solution | 5 mg/mL (DMSO:ethanol 1:1). Group: Fluorescence/luminescence spectroscopy. | |
| Abierixin | Abierixin is a polyether antibiotic isolated from Streptomyces albus NRRL B-1865. Abierixin exhibited weak antimicrobial and ionophorous activities, low toxicity but good anticoccidial activity. Synonyms: Nigericin, 3,7-deepoxy-2,3-didehydro-7-hydroxy-; (2E)-7-hydroxy-8-(2-{5'-[6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl]-2,3'-dimethyloctahydro-2,2'-bifuran-5-yl}-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]dec-7-yl)-2,4-dimethyloct-2-enoic acid. CAS No. 100634-16-0. Molecular formula: C40H68O11. Mole weight: 724.96. | |
| Grisorixin | It is a polyether antibiotic produced by the strain of Streptomyces griseus. It has anti-bacterial, filamentous and yeast fungal activities (0.1-200 μg/mL), can prevent the infection of spores of legume crops (0.01% solution), has plant toxicity (0.02% solution), and can kill potato beetles, aphids and mites (0.05%-0.1% solution) and inhibits HeLa cells. Synonyms: 30-Deoxynigericin; Nigericin, 30-deoxy-; Grisorixine; Desoxynigericin; Antibiotic K 358; K 358. CAS No. 31357-58-1. Molecular formula: C40H68O10. Mole weight: 708.96. | |
| INF 4E | INF 4E is an inhibitor of caspase-1 and NLRP3 ATPase activities. It inhibits nigericin or ATP induced pyroptosis of PMA-differentiated and LPS-primed THP-1 cells, and activates the Keap1-Nrf2 pathway. It acts by irreversibly trapping thiol nucleophiles and preventing both nigericin-triggered and ATP-pyroptosis of human THP-1 cells in a concentration- and time-dependent manner. It was used to study the electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis. Synonyms: NLRP3-IN-9; NLRP3 IN 9; NLRP3IN9; INF-4E; INF 4E; INF4E; Ethyl 2[ (2-chlorophenyl) (hydroxy)methyl]acrylate. Grades: ≥98% by HPLC. CAS No. 88039-46-7. Molecular formula: C12H13ClO3. Mole weight: 240.68. | |
| NLRP3-IN-9 | NLRP3-IN-9 is an inhibitor of caspase-1 and NLRP3 ATPase activities. It acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- and concentration-dependent manner. Uses: Designed for use in research and industrial production. Additional or Alternative Names: NLRP3-IN-9; NLRP3 IN 9; NLRP3IN9; INF-4E; INF 4E; INF4E. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 88039-46-7. Molecular formula: C12H13ClO3. Mole weight: 240.68. Purity: >98%. IUPACName: Ethyl 2[(2-chlorophenyl)(hydroxy)methyl]acrylate. Canonical SMILES: C=C(C(C1=CC=CC=C1Cl)O)C(OCC)=O. Product ID: ACM88039467. Alfa Chemistry ISO 9001:2015 Certified. Categories: NLRP3 inflammasome. | |
| Salinomycin | Salinomycin is a polyether ionophore with broad spectrum Gram +ve and anti-coccidial activity. Salinomycin has a high affinity for monovalent cations, particularly potassium. Salinomycin is used in animal health for control of coccidia and for growth promotion in ruminants. Recently, salinomycin has been shown to inhibit cancer stem cells and is > 100 times more potent than taxol. While the mechanism of action is unknown, it was noted that among the 60,000 compounds screened, another monovalent ionophore, nigericin, and a chloride channel inhibitor, avermectin, were also active. Group: Biochemicals. Grades: Highly Purified. CAS No. 53003-10-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
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