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| Product | Description | |
|---|---|---|
| Nimbolide | Nimbolide, a natural triterpenoid present in the edible parts of the neem tree (Azadirachta indica), was found to be growth-inhibitory in human colon carcinoma HT-29 cells. Nimbolide treatment of cells at 2.5-0uM resulted in moderate to very strong growth inhibition. Group: Biochemicals. Alternative Names: (4α, 5α, 6α, 7α, 15 β,17α)-. Grades: Highly Purified. CAS No. 25990-37-8. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Nimbolide | Nimbolide is a triterpene derived from the leaves and flowers of neem (Azadirachta indica). Nimbolide induces apoptosis through inactivation of NF-κB. Nimbolide inhibits CDK4/CDK6 kinase activity. Nimbolide suppresses the NF-κB, Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Powder. CAS No. 25990-37-8. Molecular formula: C27H30O7. Mole weight: 466.52. Purity: 0.98. IUPACName: methyl 2-[6-(furan-3-yl)-7,9,11,15-tetramethyl-12,16-dioxo-3,17-dioxapentacyclo[9.6.1.02,9.04,8.015,18]octadeca-7,13-dien-10-yl]acetate. Canonical SMILES: CC1=C2C(CC1C3=COC=C3)OC4C2(C(C5(C6C4OC(=O)C6(C=CC5=O)C)C)CC(=O)OC)C. Product ID: ACM25990378. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Nimbolide (4a,5a,6a,7a,15b,17a)-7,15:21,23-Diepoxy-6-hydroxy-4,8-dimethyl-1-oxo-18,24-dinor-11,12-secochola-2,13,20,22-tetraene-4,11-dicarboxylic Acid g-lactone Methyl Ester, CCRIS 5723, NSC-309909) | A terpenoid lactone derived from Azadirachta indica (Neem tree) that displays a variety of biological activities including anti-malarial and anticancer activity. Recently it has also been shown that nimbolide sensitizes colon cancer cells to TRAIL-induced apoptosis through three distinct mechanisms: reactive oxygen species and ERK-mediated up-regulation of DR5 and DR4, downregulation of cell survival proteins, and up-regulation of pro-apoptotic proteins p53 and Bax. Group: Biochemicals. Grades: Highly Purified. CAS No. 25990-37-8. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
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