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| Product | Description | |
|---|---|---|
| Ningetinib | Ningetinib is a potent, orally bioavailable small molecule tyrosine kinase inhibitor (TKI) with IC50s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively. In vivo, ningetinib (20 mg/kg) inhibits tumor growth in MKN45, Caki-1, NCI-H441, Huh-7, U87MG, and MDA-MB-231 mouse xenograft models by 53-97%. Synonyms: N-[3-Fluoro-4-[[7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl]oxy]phenyl]-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide; N-[3-Fluoro-4-[[7-(2-hydroxy-2-methylpropoxy)-4-quinolinyl]oxy]phenyl]-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide. CAS No. 1394820-69-9. Molecular formula: C31H29FN4O5. Mole weight: 728.79. |  |
| Ningetinib | Ningetinib is a potent, orally bioavailable small molecule tyrosine kinase inhibitor ( TKI ) with IC 50 s of 6.7, 1.9 and <1.0 nM for c-Met , VEGFR2 and Axl , respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1394820-69-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107145A. |  |
| Ningetinib Tosylate | Ningetinib Tosylate is a potent, orally bioavailable small molecule tyrosine kinase inhibitor ( TKI ) with IC 50 s of 6.7, 1.9 and <1.0 nM for c-Met , VEGFR2 and Axl , respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1394820-77-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-107145. | |
| Ningetinib-Tosylate | Ningetinib Tosylate is a small molecule tyrosine kinase inhibitor (TKI) with IC50 of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively. Synonyms: N-(3-Fluoro-4-((7-(2-Hydroxy-2-Methylpropoxy)Quinolin-4-Yl)Oxy)Phenyl)-1,5-Dimethyl-3-Oxo-2-Phenyl-2,3-Dihydro-1H-Pyrazole-4-Carboxamide P-Toluenesulfonate. CAS No. 1394820-77-9. Molecular formula: C38H37FN4O8S. Mole weight: 728.8. | |
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