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| Product | Description | |
|---|---|---|
| Niraparib | Niraparib is an inhibitor of PARP, which was approved by FDA for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer who are in a complete or partial response to platinum-based chemotherapy. Synonyms: MK-4827; MK 4827; MK4827; (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide; ZEJULA; 2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide. CAS No. 1038915-60-4. Molecular formula: C19H20N4O. Mole weight: 320.396. |  |
| Niraparib | Niraparib (MK-4827) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC 50 s of 3.8 and 2.1 nM, respectively. Niraparib leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-4827. CAS No. 1038915-60-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10619. |  |
| Niraparib hydrochloride | Niraparib hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC 50 s of 3.8 and 2.1 nM, respectively. Niraparib hydrochloride leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-4827 hydrochloride. CAS No. 1038915-64-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10619A. | |
| Niraparib impurity 1 | Niraparib impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1038915-58-0. Molecular formula: C19H20N4O. Mole weight: 320.4. Catalog: APB1038915580. |  |
| Niraparib impurity 7 | Niraparib impurity 7. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1038915-73-9. Molecular formula: C26H28N4O4S. Mole weight: 492.59. Catalog: APB1038915739. | |
| Niraparib impurity 9 | Niraparib impurity 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1334823-70-9. Molecular formula: C11H16N2. Mole weight: 176.26. Catalog: APB1334823709. | |
| Niraparib tosylate | Niraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC 50 of 3.8 and 2.1 nM, respectively. Niraparib tosylate leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-4827 tosylate. CAS No. 1038915-73-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10619B. | |
| Niraparib tosylate hydrate | Niraparib (MK-4827) tosylate hydrate is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC 50 s of 3.8 and 2.1 nM, respectively. Niraparib tosylate hydrate leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-4827 tosylate hydrate. CAS No. 1613220-15-7. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10619E. | |
| 2-?Chloro-?1-?(3-?fluorobenzyloxy)?-?4-?nitrobenzene | 2-?Chloro-?1-?(3-?fluorobenzyloxy)?-?4-?nitrobenzene is a reagent used in the synthesis of novel indole-2-carboxamide derivative as anti-inflammatory agents used in the treatment of sepsis. Also an intermediate of Niraparib (N481400), a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. Group: Biochemicals. Grades: Highly Purified. CAS No. 443882-99-3. Pack Sizes: 5g, 10g. Molecular Formula: C13H9ClFNO3, Molecular Weight: 281.67. US Biological Life Sciences. |  Worldwide |
| MK-4827 (R-enantiomer) | MK-4827 (R-enantiomer) is the R form of MK-4827, which is a PARP inhibitor developed for the treatment of ovarian cancer. Synonyms: (R)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide; Niraparib R-enantiomer; MK4827 R-enantiomer; MK 4827 R-enantiomer; MK-4827 R-enantiomer. Grades: > 98%. CAS No. 1038915-58-0. Molecular formula: C19H20N4O. Mole weight: 320.396. | |
| MK-4827 tosylate | MK-4827 tosylate is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM. It has a great activity in cancer cells with mutant BRCA-1 and BRCA-2, >330-fold selective against PARP3, V-PARP and Tank1. Synonyms: (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide 4-methylbenzenesulfonate; MK-4827; MK-4827; MK4827; MK4827-tosylate; Niraparib tosylate. Grades: >98%. CAS No. 1038915-73-9. Molecular formula: C26H28N4O4S. Mole weight: 492.59. | |
| N,S-Dicarboxymethyl-L-cysteine | N,S-Dicarboxymethyl-L-cysteine is an impurity of carbocysteine. Synonyms: N,S-Bis(carboxymethyl)-L-cysteine; Niraparib Impurity compound (c); (2R)-2-(carboxymethylamino)-3-(carboxymethylsulfanyl)propanoic acid; L-Cysteine, N,S-bis(carboxymethyl)-. Molecular formula: C7H11NO6S. Mole weight: 237.23. | |
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