Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| Nitroreductase from Escherichia coli | ?90% (SDS-PAGE), recombinant, expressed in E. coli. Group: Fluorescence/luminescence spectroscopy. |  |
| Nitroreductase from Escherichia coli, Recombinant | Nitroreductase increases the sensitivity of organisms to nitro-containing drugs such as metronidazole by converting the nitro group to a cytotoxic nitro radical. Shows ability to reduce quinines. Enzyme for activating prodrugs in antibody directed enzyme prodrug therapy. Applications: Nitroreductase has been used in a study that used a set of pcr primers to clone a gene encoding a hypothetical nitroreductases (named as ssap-ntrb) from uropathogenic staphyl oc occus. it has also been used to improve prodrug activation. nitroreductase from escherichia coli has been used in a study to assess anaerobic bacteria as a gene delivery system for cancer treatment. it has also been used in a study to investigate its applications in antibody-directed enzyme prodrug therapy. Group: Enzymes. Synonyms: Nitroreductase. Purity: > 90% (SDS-PAGE). Nitroreductase. Mole weight: monomer mol wt 24 kDa. Storage: -20°C. Source: E. coli. Species: Escherichia coli. Nitroreductase. Cat No: NATE-0488. |  |
| Tretazicar | Tretazicar (CB1954) is a dinitrobenzamide prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide (EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. CB1954 has been proposed for use in enzyme-prodrug gene therapy systems with the Escherichia coli enzyme nitroreductase (Ntr). Ntr converts CB1954 to 2- and 4-hydroxylamino derivatives, whereupon the non-enzymatic reaction of the 4-hydroxylamino derivative with cellular thio- esters generates a potent cytotoxic bifunctional alkylating agent capable of cross-linking DNA. Ntr delivery has been achieved in vitro using retroviral and adenoviral vectors and confirmed by immunocytochemical demonstration of Ntr expression. The Ntr-expressing cells have been shown to be sensitized to CB1954 by up to 2000-fold. The Ntr-CB1954 system shows effective bystander killing in mixed populations of Ntr-expressing and non-expressing cells treated with CB1954. The efficacy of this enzyme-prodrug approach in model systems compared with other VDEPT approaches demonstrates the feasibility and future promise of this gene therapy strategy. Uses: Antineoplastic agents. Synonyms: CB1954; CB-1954; CB 1954; Tretazicar. Grades: 0.98. CAS No. 21919-05-1. Molecular formula: C9H8N4O5. Mole weight: 252.186. |  |
Our database is helping our users find suppliers everyday.
