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| Product | Description | |
|---|---|---|
| Nocodazole | 10mg Pack Size. Group: Analytical Reagents, Biochemicals, Diagnostic Raw Materials. Formula: C14H11N3O3S. CAS No. 31430-18-9. Prepack ID 90028754-10mg. Molecular Weight 301.32. See USA prepack pricing. |  |
| Nocodazole | Nocodazole, also called Oncodazole, reversibly inhibits microtubule polymerization so it has anti-neoplastic effect. It is inhibitor of Abl (IC50= 0.21 μM), Abl(E255K) (IC50= 0.53 μM)and Abl(T315I) (IC50= 0.53 μM). in vitro: a high-affinity ligand for Abl phosphorylated (Kd= 0.091 μM), c-Kit (Kd= 1.6 μM), BRAF (Kd= 1.8 μM), and MEK (Kd= 1.6 μM) in vivo: combined with Ketoconazole strongly enhances apoptosis of COLO 205 tumor xenografts. Synonyms: methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate; nocodazole; Oncodazole; 31430-18-9; R 17934; Nocodazolum; Nocidazole; Nocodazol; NSC 238159; Methyl N-(5-thenoyl-2-benzimidazolyl)carbamate; Methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate; NSC-238159; R-17934; R 17,934; C14H11N3O3S; Methyl 5-(2-thenoyl)-2-benzimidazolecarbamate; Nocodazole [USAN:INN]. CAS No. 31430-18-9. Molecular formula: C14H11N3O3S. Mole weight: 301.32. |  |
| Nocodazole | Nocodazole, an inhibitor of microtubule formation, was found to greatly inhibit cell division around the mound stage as well as during the vegetative growth phase, when applied to exponentially growing Ax-2 cells. Mitotic arrest of cells with nocodazole can be used to study phosphorylation of microtubule-associated proteins which increase during mitosis, concomitant with increased microtubule dynamics. Nocodazole has been found to dramatically inhibit T cell antigen receptor (TCR) signaling, independently of its ability to depolymerize microtubules. Nocodazole arrests the cell cycle at G2/M phase and prevents phosphorylation of the T cell antigen receptor and inhibits its activity. Group: Biochemicals. Alternative Names: Methyl N- (5-thenoyl-2-benzimidazolyl) carbamate; Methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate; Oncodazole; R 17934; [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamic acid methyl ester. Grades: Molecular Biology Grade. CAS No. 31430-18-9. Pack Sizes: 20mg, 50mg, 100mg, 250mg. Molecular Formula: C14H11N3O3S, Molecular Weight: 301.32. US Biological Life Sciences. |  Worldwide |
| Nocodazole | Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl, and activates CRISPR/Cas9. Group: Inhibitors. Alternative Names: [5-(2-THIENYLCARBONYL)-1H-BENZIMIDAZOL-2-YL]CARBONIC ACID, METHYL ESTER;METHYL[5-(2-THIENYLCARBONYL)-1H-BENZIMADAZOL-2-YL]CARBAMATE;METHYL-(5-[2-THIENYLCARBONYL]-1H-BENZIMIDAZOL-2-YL)CARBAMATE;METHYL [5-(2-THIENYLCARBONYL)-1H-BENZ-IMIDAZOLE-2-YL]-CARBAMATE;METHYL-(5-[2-THIENYLCARBONYL]-1H-BENZIMODAZOL-2YL)-CARBAMATE;METHYL N-(5-THENOYL-2-BENZIMIDAZOLYL)CARBAMATE; NOCODAZOLE; R 17934. CAS No. 31430-18-9. Molecular formula: C14H11N3O3S. Mole weight: 301.32. Appearance: powder. Purity: 0.9966. Density: 1.49. Catalog: ACM31430189. |  |
| Nocodazole | Nocodazole (Oncodazole) is a rapidly-reversible inhibitor of microtubule. Nocodazole binds to β-tubulin and disrupts microtubule assembly/disassembly dynamics, which prevents mitosis and induces apoptosis in tumor cells. Nocodazole inhibits Bcr-Abl , and activates CRISPR/Cas9. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Oncodazole; R17934. CAS No. 31430-18-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13520. |  |
| Nocodazole Solution in DMSO, 5mg/ml | Nocodazole, an inhibitor of microtubule formation, was found to greatly inhibit cell division around the mound stage as well as during the vegetative growth phase, when applied to exponentially growing Ax-2 cells. Mitotic arrest of cells with nocodazole can be used to study phosphorylation of microtubule-associated proteins which increase during mitosis, concomitant with increased microtubule dynamics. Nocodazole has been found to dramatically inhibit T cell antigen receptor (TCR) signaling, independently of its ability to depolymerize microtubules. Nocodazole arrests the cell cycle at G2/M phase and prevents phosphorylation of the T cell antigen receptor and inhibits its activity. Group: Biochemicals. Alternative Names: Methyl N- (5-thenoyl-2-benzimidazolyl) carbamate; Methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate; Oncodazole; R 17934; [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamic acid methyl ester. Grades: Molecular Biology Grade. CAS No. 31430-18-9. Pack Sizes: 1ml, 5ml, 10ml. Molecular Formula: C14H11N3O3S, Molecular Weight (dry powder): 301.32. US Biological Life Sciences. | Worldwide |
| Boc-AEVD-CHO trifluoroacetate salt | Boc-AEVD-CHO is an inhibitor of caspase-8 (Ki = 1.6 nM) that also inhibits caspase-1, -3, -6, and -9 (Kis = <12, 42, 52, and 48 nM, respectively). It inhibits apoptosis induced by the aneugen nocodazole in isolated human peripheral blood mononuclear cells (PBMCs) at concentration of 300 μM. Synonyms: Boc-Ala-Glu-Val-Asp-CHO. Grades: ≥95%. Molecular formula: C22H36N4O10·xCF3COOH. Mole weight: 516.54. | |
| MPS1 Inhibitor, NMS-P715 ( (N- (2, 6-diethylphenyl) -1-methyl-8- ({4-[ (1-methylpiperidin-4-yl) carbamoyl]-2- (trifluoromethoxy) phenyl}amino) -4, 5-dihydro-1H-pyrazolo[4, 3-h]quinazoline-3-carboxamide) ) | An orally bioavailable, ATP-competitive, pyrazolo-quinazoline, MPS1 inhibitor (IC50=182nM, Ki=0.99nM) that is shown to act in a reversible and time-dependent manner. It demonstrates selectivity for MPS1 against a panel of 60 kinases, displaying activity against only three kinases, CK2, MELK, and NEK6 (<10uM), but not against other mitotic kinases including PLK1, CDK1, Aurora A, Aurora B, or the SAC kinase BUB1, in an in vitro kinase assay. It promotes massive SAC (spindle assembly checkpoint) override (EC50=65nM) in nocodazole-arrested U20S cells and elicits a reduction in the G1 and G2/M phase of the cell cycle in A2780 ovarian cancer cells, similar to RNAi-mediated MPS1 silencing. In addition, it is shown to inactivate SAC, delocalize kinetochore components, and inhibit the proliferation of select cancer cell lines (IC50 ~1uM), without marked activity among a panel of 127 normal cell lines. Also, it inhibits A2780 tumor xenograft growth in mice (90mg/kg/day, o.s., in vivo) by 53% wit Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
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