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Nodularin Nodularin is a pentapeptide toxin produced by the cyanobacterium Nodularia spumigena. It acts as a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. Synonyms: Nodularin; Nodularin R; Nodularin-R; UNII-0979BIK2QU; 0979BIK2QU; HSDB 7749; DTXSID60880022; (2Z,5R,6S,9S,12S,13S,16R)-9-[3-(diaminomethylideneamino)propyl]-2-ethylidene-12-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-1,6,13-trimethyl-3,7,10,14,19-pentaoxo-1,4,8,11,15-pentazacyclononadecane-5,16-dicarboxylic acid; Cyclo((Z)-2,3-didehydro-N-methyl-2-aminobutanoyl-erythro-3-methyl-D-beta-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyl-3-aminodecanoyl-D-gamma-glutamyl); Nodularin, cyanotoxin. Grades: ≥95%. CAS No. 118399-22-7. Molecular formula: C41H60N8O10. Mole weight: 825. BOC Sciences 9
Nodularin (in ethanol) Nodularin is a hepatotoxic monocylic pentapeptide produced by cyanobacterium Nodularia spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026nm, respectively. It inhibits PP2B only at higher concentrations (IC50=1.8uM). Group: Biochemicals. Alternative Names: Cyclo[(2S, 3S, 4E, 6E, 8S, 9S)-3-amino-9-methoxy-2, 6, 8-trimethyl-10-phenyl-4, 6-decadienoyl-D-γ-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D- β-aspartyl-L-arginyl]; Cyclo[(Z)-2,3-didehydro-N-methyl-2-aminobutanoyl-erythro-3-methyl-D- β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyl-3-aminodecanoyl-D-γ-glutamyl]; 1, 4, 8, 11, 15-Pentaazacyclononadecan e Cyclic Peptide Deriv.; Nodularin R. Grades: Highly Purified. CAS No. 118399-22-7. Pack Sizes: 100ug. Molecular Formula: C??H??N?O??, Molecular Weight: 824.96. US Biological Life Sciences. USBiological 4
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