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| Product | Description | |
|---|---|---|
| NPS-2143 hydrochloride | NPS-2143 hydrochloride (SB-262470A hydrochloride), an orally active calcilytic agent, is a selective and potent calcium ion-sensing receptor (CaSR) antagonist. NPS-2143 hydrochloride (SB-262470A hydrochloride) blocks increases in cytoplasmic Ca 2+ concentrations ( IC 50 =43 nM) elicited by activating the Ca 2+ receptor in HEK 293 cells expressing the human Ca 2+ receptor [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB-262470A hydrochloride. CAS No. 324523-20-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-10171. |  |
| NPS-2143 hydrochloride | NPS-2143 (SB-262,470A) is a calcilytic drug which acts as an antagonist at the Calcium-sensing receptor (CaSR), and consequently stimulates release of parathyroid hormone. Calcilytic drugs have been researched as potential treatments for osteoporosis, and as the first such compound developed, NPS-2143 is still widely used in research into the CaSR receptor as well as design of newer calcilytic agents. Synonyms: NPS2143 hydrochloride; NPS 2143 hydrochloride. Grades: >98%. CAS No. 324523-20-8. Molecular formula: C24H26Cl2N2O2. Mole weight: 445.38. |  |
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