Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
| Product | Description | |
|---|---|---|
| NS1643 | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| NS1643 | NS1643 is a partial agonist of human ether-a-go-go-related gene ( hERG ) K + channels with an EC 50 of 10.5 μM. NS1643 inhibits the growth of breast cancer tumors in TNBC mouse models. NS1643 inhibits cell migration and invasion of breast cancer cells [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 448895-37-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16916. |  |
| Herg Activator (NS1643, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea, Human ether-a-go-go related gene (hERG) K+ channel activator, KV11.1 Channel Activator) | A diphenolurea compound that selectively activates human ether-a-go-go-related gene (hERG) K+-channel (EC50=10.5uM). Shown to significantly increase both steady-state and peak tail currents of hERG channels, but exhibits only a trivial effect on Kv4.3 and Kv1.5 channels. Causes a significant reduction in action potential duration (APD90) in patch clamp assays in Xenopus oocytes, HEK293 cells, and guinea pig cardiamyocyes that can be reversed by the addition of E-4031, a specific blocker of hERG channels. Also shown to activate IKr channel in cardiomyocytes and increase post-repolarization refractory time thereby alleviating hyper-excitability and producing antiarrhythmic effects. It can also restore IKr reduced by down-regulation of IKr expression. Group: Biochemicals. Grades: Highly Purified. CAS No. 448895-37-2. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O?, Molecular Weight: 380.2. US Biological Life Sciences. |  Worldwide |
| NS 1643 | NS 1643 is human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM). Uses: Kv11.1 channel activator. Synonyms: NS-1643; NS 1643; NS1643. 1,3-Bis(2-hydroxy-5-trifluoromethylphenyl)urea;N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea. Grades: ≥98 %. CAS No. 448895-37-2. Molecular formula: C15H10F6N2O3. Mole weight: 380.06. |  |
Our database is helping our users find suppliers everyday.
