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Nsc 663284 NSC 663284 (DA-3003-1) is a potent, cell-permeable, and irreversible Cdc25 dual specificity phosphatase inhibitor, has an IC50 for Cdc25B2 of 0.21 μM. NSC 663284 exhibits mixed competitive kinetics against Cdc25A, Cdc25B(2), and Cdc25C with Ki values of 29, 95, and 89 nM, respectively. NSC 663284 inhibits NSD2 (IC50 of 170 nM) through a direct interaction with the catalytic SET domain (Kd of 370 nM). Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 383907-43-5. Molecular formula: C15H16ClN3O3. Mole weight: 321.762. Purity: >99 %. Canonical SMILES: O=C(C(Cl)=C1NCCN2CCOCC2)C3=C(N=CC=C3)C1=O. Product ID: ACM383907435. Alfa Chemistry — ISO 9001:2015 Certified. Alfa Chemistry.
NSC 663284 ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. Alfa Chemistry Analytical Products
NSC 663284 NSC 663284. Group: Biochemicals. Grades: Purified. CAS No. 383907-43-5. Pack Sizes: 10mg. US Biological Life Sciences. USBiological 5
Worldwide
NSC 663284 NSC 663284 is a potent, irreversible, cell permeable and mixed competitive Cdc25 dual specificity phosphatases inhibitor (IC50= 0.21 μM), and poorly inhibits other phosphatases, including Vaccinia virus VH1-related (IC50 = 4.0 μM), PTP1B (no inhibition), and the mitogen-activated protein kinase phosphatases (MKP) MKP-1 or -3 (no inhibition). Synonyms: 6-chloro-7-(2-morpholin-4-ylethylamino)quinoline-5,8-dione; SPS8I1; SPS-8I1; SPS 8I1; DA3003-1; DA3003 1; DA30031; NSC-663284; NSC 663284; NSC663284. CAS No. 383907-43-5. Molecular formula: C15H16ClN3O3. Mole weight: 321.76. BOC Sciences 9

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