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| Product | Description | |
|---|---|---|
| NSC305787 | NSC305787 is a small molecule inhibitor of PKC. Its IC50 value is 8.3 μM, 9.4 μM, 55 μM for PKC&Lota; phosphorylation of recombinant ezrin, moesin and radixin. It is proved a novel targeted therapy which could inhibit ezrin protein as an approach to prevent tumor metastasis in vitro. It could inhibited T567 phosphorylation and actin binding of endogenous ezrin at 10 μM without altering cellular ezrin levels and inhibit the lung metastases growth of high-ezrin-expressing K7M2 OS cells in this organ culture assay. It cause reduced cell motility phenotypes in zebrafish in vivo. Uses: Nsc305787 is proved a novel targeted therapy which could inhibit ezrin protein as an approach to prevent tumor metastasis in vitro. it could inhibited t567 phosphorylation and actin binding of endogenous ezrin at 10 μm without altering cellular ezrin levels and inhibit the lung metastases growth of high-ezrin-expressing k7m2 os cells in this organ culture assay. Synonyms: NSC 305787; NSC-305787; NSC 305787. Grades: >98%. CAS No. 785718-37-8. Molecular formula: C25H30Cl2N2O. Mole weight: 445.42. |  |
| NSC305787 hydrochloride | NSC305787 hydrochloride is a small molecule inhibitor of PKC (IC50=8.3 μM) that directly inhibits ezrin protein as an approach to prevent tumor metastasis. Uses: A small molecule inhibitor of pkc. Synonyms: NSC-305787 Hydrochloride; NSC 305787 Hydrochloride; NSC305787 Hydrochloride; NSC-305787 HCl; NSC 305787 HCl; NSC305787 HCl; [2-(Adamantan-1-yl)-6,8-dichloro-4-quinolinyl](2-piperidinyl)methanol hydrochloride;[2-(Adamantan-1-yl)-6,8-dichloro-4-quinolinyl](2-piperidinyl)methanol hydrochloride. Grades: ≥95%. CAS No. 53868-26-1. Molecular formula: C25H31Cl3N2O. Mole weight: 481.89. | |
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