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| Product | Description | |
|---|---|---|
| NUCLEOSIDE PHOSPHORYLASE | NUCLEOSIDE PHOSPHORYLASE. Synonyms: Nucleoside Phosphorylase bacterial,PNP, Purine nucleoside phosphorylase, Purine nucleoside:orthophosphate ribosyltransferase;Purine nucleoside phosphorylase [ >=200 units/mg];Deoxyribonucleoside phosphorylase;Purine deoxynucleoside phosphorylase;Purine deoxyribonucleoside phosphorylase;Purine ribonucleoside phosphorylase;PNP/Purine-nucleoside phosphorylase;Nucleoside Phosphorylase from microorganisms. CAS No. 9030-21-1. Pack Sizes: 1 kg. Product ID: CDF4-0059. Molecular formula: C10H12N4O4. Category: Enzyme Preparations. Product Keywords: Food Ingredients; Enzyme Preparations; NUCLEOSIDE PHOSPHORYLASE; CDF4-0059; 9030-21-1; C10H12N4O4; 232-857-3; 9030-21-1. Purity: 0.98. EC Number: 232-857-3. Physical State: lyophilized Powder. Storage: -20°C. |  |
| Nucleoside Phosphorylase from bacterial, Recombinant | In enzymology, a purine-nucleoside phosphorylase (EC 2.4.2.1) is an enzyme that catalyzes the chemical reaction:purine nucleoside + phosphate<-> purine + alpha-D-ribose 1-phosphate. Thus, the two substrates of this enzyme are purine nucleoside and phosphate, whereas its two products are purine and alpha-D-ribose 1-phosphate. This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. This enzyme participates in 3 metabolic pathways:purine metabolism, pyrimidine metabolism, and nicotinate and nicotinamide metabolism. Applications: Nucleoside phosphorylase is used in coupled enzyme systems to measure protein dephosphorylation. bac...eoxynucleoside phosphorylase; purine deoxyribonucleoside phosphorylase; purine nucleoside phosphorylase; purine ribonucleoside phosphorylase; 9030-21-1; EC 2.4.2.1. Enzyme Commission Number: EC 2.4.2.1. CAS No. 9030-21-1. PNPase. Activity: > 10 units/mg protein. Storage: -20°C. Form: lyophilized powder. Source: E. coli. Species: Bacterial. purine-nucleoside phosphorylase; inosine phosphorylase; PNP; PNPase; PUNPI; PUNPII; inosine-guanosine phosphorylase; nucleotide phosphatase; purine deoxynucleoside phosphorylase; purine deoxyribonucleoside phosphorylase; purine nucleoside phosphorylase; purine ribonucleoside phosphorylase; 9030-21-1; EC 2.4.2.1. Cat No: NATE-0607. |  |
| Native Bacillus sp. Purine Nucleoside Phosphorylase | Purine nucleoside phosphorylase (also known as PNPase) is an enzyme (EC 2.4.2.1) involved in purine metabolism. PNP metabolizes adenosine into adenine, inosine into hypoxanthine, and guanosine into guanine, in each case creating ribose phosphate. NP encodes the enzyme purine nucleoside phosphorylase that together with adenosine deaminase (ADA) serves a key role in purine catabolism, referred to as the salvage pathway. Mutations in either enzyme result in a severe combined immunodeficiency (SCID). Confusingly, the same abbreviation (PNPase), is also used for another, otherwise unrelated, enzyme, namely Polynucleotide Phosphorylase. Purine nucleoside phosphorylase produced in microorganism has a molecular mass of 32 kda. Applications: Useful for enzymatic determination of inorganic phosphate. Group: Enzymes. Synonyms: inos. Enzyme Commission Number: EC 2.4.2.1. CAS No. 9030-21-1. PNPase. Activity: > 500U/mL. Appearance: Colourless to light brown solution. Storage: -20°C. Form: Liquid. Source: Bacillus sp. inosine phosphorylase; PNPase; PUNPI; PUNPII; inosine-guanosine phosphorylase; nucleotide phosphatase; purine deoxynucleoside phosphorylase; purine deoxyribonucleoside phosphorylase; purine nucleoside phosphorylase; purine ribonucleoside phosphorylase; purine-nucleoside: phosphate ribosyltransferase; EC 2.4.2.1. Cat No: DIA-164. | |
| Native Microorganism Purine-nucleoside phosphorylase | In enzymology, a purine-nucleoside phosphorylase (EC 2.4.2.1) is an enzyme that catalyzes the chemical reaction: purine nucleoside + phosphate <-> purine + alpha-D-ribose 1-phosphate. Thus, the two substrates of this enzyme are purine nucleoside and phosphate, whereas its two products are purine and alpha-D-ribose 1-phosphate. This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. Applications: This enzyme is useful for enzymatic determination of inorganic phosphorus, 5'-nucleotidase and adenosine deaminase when coupled with xanthine oxidase and uricase. Group: Enzymes. Synonyms: EC 2.4.2.1; inosine phosphorylase; PNPase; PUNPI; PUNPII; inosine-guanosine phosphorylase; nucleotide phosphatase; purine deoxynuc. Enzyme Commission Number: EC 2.4.2.1. CAS No. 9030-21-1. PNPase. Mole weight: approx. 120 kDa. Activity: Grade? 15U/mg-solid or more. Stability: Stable at-20°C for at least 12 months. Appearance: White amorphous powder, lyophilized. Source: Microorganism. EC 2.4.2.1; inosine phosphorylase; PNPase; PUNPI; PUNPII; inosine-guanosine phosphorylase; nucleotide phosphatase; purine deoxynucleoside phosphorylase; purine deoxyribonucleoside phosphorylase; purine nucleoside phosphorylase; purine ribonucleoside phosphorylase; purine-nucleoside: phosphate ribosyltransferase. Cat No: DIA-216. | |
| Native Microorganisms Nucleoside Phosphorylase | In enzymology, a purine-nucleoside phosphorylase (EC 2.4.2.1) is an enzyme that catalyzes the chemical reaction:purine nucleoside + phosphate<-> purine + alpha-D-ribose 1-phosphate. Thus, the two substrates of this enzyme are purine nucleoside and phosphate, whereas its two products are purine and alpha-D-ribose 1-phosphate. This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. This enzyme participates in 3 metabolic pathways:purine metabolism, pyrimidine metabolism, and nicotinate and nicotinamide metabolism. Applications: Nucleoside phosphorylase is used in coupled enzyme systems to measure protein dephosphorylation. this e...osphorylase; nucleotide phosphatase; purine deoxynucleoside phosphorylase; purine deoxyribonucleoside phosphorylase; purine nucleoside phosphorylase; purine ribonucleoside phosphorylase; 9030-21-1; EC 2.4.2.1. Enzyme Commission Number: EC 2.4.2.1. CAS No. 9030-21-1. PNPase. Mole weight: mol wt ~120 kDa. Activity: > 10 units/mg protein. Storage: -20°C. Form: Lyophilized powder containing potassium gluconate, mannitol and EDTA. Source: Microorganisms. purine-nucleoside phosphorylase; inosine phosphorylase; PNP; PNPase; PUNPI; PUNPII; inosine-guanosine phosphorylase; nucleotide phosphatase; purine deoxynucleoside phosphorylase; purine deoxyribonucleoside phosphorylase; pu | |
| purine-nucleoside phosphorylase | Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase. Group: Enzymes. Synonyms: inosine phosphorylase; PNPase; PUNPI; PUNPII; inosine-guanosine phosphorylase; nucleotide phosphatase; purine deoxynucleoside phosphorylase; purine deoxyribonucleoside phosphorylase; purine nucleoside phosphorylase; purine ribonucleoside phosphorylase. Enzyme Commission Number: EC 2.4.2.1. CAS No. 9030-21-1. PNPase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2638; purine-nucleoside phosphorylase; EC 2.4.2.1; 9030-21-1; inosine phosphorylase; PNPase; PUNPI; PUNPII; inosine-guanosine phosphorylase; nucleotide phosphatase; purine deoxynucleoside phosphorylase; purine deoxyribonucleoside phosphorylase; purine nucleoside phosphorylase; purine ribonucleoside phosphorylase. Cat No: EXWM-2638. | |
| Purine nucleoside phosphorylase, Microorganism | Purine nucleoside phosphorylase, Microorganism (PNP) is a key enzyme in purine metabolism, which is involved in the purine rescue pathway. The deficiency of Purine nucleoside phosphorylase resulted in impaired T cell function. In the presence of inorganic orthophosphate as the second substrate, Purine nucleoside phosphorylase catalyzes the breaking of the glycosidic bond between ribose and deoxyribonucleoside to generate purine base and ribose (deoxyribose) -1-phosphate [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PNP. CAS No. 9030-21-1. Pack Sizes: 100 U. Product ID: HY-P2724. |  |
| Purine nucleoside phosphorylase, Recombinant | Purine nucleoside phosphorylase is an enzyme involved in purine metabolism. PNP metabolizes adenosine into adenine, inosine into hypoxanthine, and guanosine into guanine. Mutations in the PNP gene are responsible for purine nucleoside phosphorylase deficiency. Applications: Purine nucleoside phosphorylase is used to study nucleotide salvage pathways and purine metabolism. it is used to study purine nucleoside phosphorylase deficiency and responsible pnp genetic mutations. this product is recombinant and expressed in e. coli. Group: Enzymes. Synonyms: purine-nucleoside phosphorylase; inosine phosphorylase; PNPase; PUNPI; PUNPII; inosine-guanosine phosphorylase; nucleotide phosphatase; purine deoxynucleoside phosphorylase; purine deoxyribonucleoside phosphorylase; purine nucleoside phosphorylase; purine ribonucleoside phosp. Enzyme Commission Number: EC 2.4.2.1. CAS No. 9030-21-1. PNPase. Activity: > 120 U/mL. Storage: -20°C. Form: buffered aqueous solution (100 mM phosphate buffer with 1 mM MgCl2. Source: E. coli. purine-nucleoside phosphorylase; inosine phosphorylase; PNPase; PUNPI; PUNPII; inosine-guanosine phosphorylase; nucleotide phosphatase; purine deoxynucleoside phosphorylase; purine deoxyribonucleoside phosphorylase; purine nucleoside phosphorylase; purine ribonucleoside phosphorylase; EC 2.4.2.1; 9030-21-1. Cat No: NATE-0644. | |
| pyrimidine-nucleoside phosphorylase | Unlike EC 2.4.2.3, uridine phosphorylase, and EC 2.4.2.4, thymidine phosphorylase, this enzyme can accept both the ribonucleoside uridine and the 2'-deoxyribonucleosides 2'-deoxyuridine and thymidine. The reaction is reversible, and the enzyme does not distinguish between α-D-ribose 1-phosphate and 2-deoxy-α-D-ribose 1-phosphate in the synthetic direction. Group: Enzymes. Synonyms: Py-NPase; pdp (gene name). Enzyme Commission Number: EC 2.4.2.2. CAS No. 9055-35-0. PyNPase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2647; pyrimidine-nucleoside phosphorylase; EC 2.4.2.2; 9055-35-0; Py-NPase; pdp (gene name). Cat No: EXWM-2647. | |
| Pyrimidine nucleoside phosphorylase | recombinant, expressed in E. coli, ?1300 U/mL. Group: Fluorescence/luminescence spectroscopy. |  |
| Pyrimidine nucleoside phosphorylase, Recombinant | Pyrimidine nucleoside phosphorylase (PyNPase) is a glycosyltransferase that catalyzes the conversion of pyrimidine nucleoside and phosphate to a pyrimidine base and α-D-ribose 1-phosphate. PyNPase plays a significant role in breast cancer angiogenesis. Applications: Pyrimidine nucleoside phosphorylase (pynpase) may be used as a marker to predict the malignant potential of breast cancer, especially lymph node metastasis. pynpase is used to study breast cancer, specifically its role in angiogenesis. Group: Enzymes. Synonyms: Pyrimidine nucleoside phosphorylase; EC 2.4.2.2; Py-NPase; 9055-35-0; pdp (gene name); PyNPase. Enzyme Commission Number: EC 2.4.2.2. CAS No. 9055-35-0. PyNPase. Activity: > 1300 U/mL. Storage: -20°C. Source: E. coli. Pyrimidine nucleoside phosphorylase; EC 2.4.2.2; Py-NPase; 9055-35-0; pdp (gene name); PyNPase. Cat No: NATE-0646. | |
| Recombinant mutant (Met62Val) purine nucleoside phosphorylase from E. coli | Purine nucleoside phosphorylase is an enzyme involved in purine metabolism. PNP metabolizes adenosine into adenine, inosine into hypoxanthine, and guanosine into guanine. Mutations in the PNP gene are responsible for purine nucleoside phosphorylase deficiency. Applications: These enzymes are widely used for the synthesis of modified nucleotides (virasol, cladribine, fludarabine) which are efficient antiviral and antitumor drugs. Group: Enzymes. Synonyms: purine-nucleoside phosphorylase; inosine phosphorylase; PNPase; PUNPI; PUNPII; inosine-guanosine phosphorylase; nucleotide phosphatase; purine deoxynucleoside phosphorylase; purine deoxyribonucleoside phosphorylase; purine nucleoside phosphorylase;. Enzyme Commission Number: EC 2.4.2.1. CAS No. 9030-21-1. Purity: > 95 %. PNPase. Mole weight: 156 kDa. Activity: 27 U/mg. Appearance: Colourless clear liquid. Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Source: E. coli. Species: E. coli. purine-nucleoside phosphorylase; inosine phosphorylase; PNPase; PUNPI; PUNPII; inosine-guanosine phosphorylase; nucleotide phosphatase; purine deoxynucleoside phosphorylase; purine deoxyribonucleoside phosphorylase; purine nucleoside phosphorylase; purine ribonucleoside phosphorylase; EC 2.4.2.1; 9030-21-1. Cat No: NATE-1000. | |
| 2,3,5-Tri-O-acetyl Guanosine-13C2,15N | 2,3,5-Tri-O-acetyl Guanosine-13C2,15N is an intermediate in the synthesis of 8-Aminoguanosine-13C2,15N (A609877). 8-Aminoguanosine-13C2,15N is an isotopic labelled compound of 8-Aminoguanosine (A609875), which is a potent inhibitor of purine nucleoside phosphorylase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C1413C2H19N415NO8. US Biological Life Sciences. |  Worldwide |
| 2-Amino-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one | 9-Deazaguanine is an analog of guanine that acts as an inhibitor of purine nucleoside phosphorylase (PNP; Kd=160 nM). Synonyms: 2-amino-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one; 2-amino-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one. Grades: > 97 %. CAS No. 65996-58-9. Molecular formula: C6H6N4O. Mole weight: 150.14. |  |
| 2'-Deoxyinosine | 2-deoxyadenosine inhibits the growth of human colon-carcinoma cell lines and is found to be associated with purine nucleoside phosphorylase (PNP) deficiency. Uses: Scientific research. Group: Natural products. CAS No. 890-38-0. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W008638. | |
| 2-Fluoroadenine | A purine nucleoside phosphorylase gene therapy for human malignancy. Group: Biochemicals. Alternative Names: 2-Fluoro-9H-purin-6-amine; 2-Fluoro-1H-purin-6-amine; 2-Fluoro-adenine; 2-Fluoro-6-aminopurine; NSC 27364. Grades: Highly Purified. CAS No. 700-49-2. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| 3',5'-Di-O-acetyl-5-fluoro-O4-(2,4,6-trimethylphenyl)-2'-O-methyluridine | 3',5'-Di-O-acetyl-5-fluoro-O4-(2,4,6-trimethylphenyl)-2'-O-methyluridine is a derivative of 6-Methyluridine, which is an exhibited weak antimalarial activity against P. falciparum 3D7 isolate. It is a weak substrate of Escherichia coli pyrimidine nucleoside phosphorylase. Synonyms: 5-Fluoro-4-O-(2,4,6-trimethylphenyl)-2',3',5'-triacetate Uridine. CAS No. 869355-32-8. Molecular formula: C23H27FN2O8. Mole weight: 478.47. | |
| 3'-Deoxyguanosine | 3'-Deoxyguanosine is a ligand that can be complexed with enzymes, such as purine nucleoside phosphorylase, and receptors. Synonyms: 2-Amino-9-((2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one; 3'-Deoxy-D-guanosine; 9-(3-Deoxy-β-D-erythro-pentofuranosyl)-Guanine; 2-amino-9-(3-deoxy-β-D-erythro-pentofuranosyl)-9H-purin-6-ol. Grades: ≥95%. CAS No. 3608-58-0. Molecular formula: C10H13N5O4. Mole weight: 267.24. | |
| 4-Nitrophenyl b-D-ribofuranoside | 4-Nitrophenyl b-D-ribofuranoside, a complex biochemical reagent utilized in laboratory settings as a substrate in the detection of numerous enzymes with which it imperatively interacts. The composition is particularly central to assays of phosphoribosylpyrophosphate synthetase, nucleoside phosphorylase, and ribosyltransferases, and is also highly effective in synthesizing nucleotides and nucleosides for further biochemical analysis. Synonyms: PNP-b-D-riboside. CAS No. 59495-69-1. Molecular formula: C11H13NO7. Mole weight: 271.22. | |
| 6-Benzylamino-9-(2'-deoxy-b-D-ribofuranosyl)purine | 6-Benzylamino-9-(2'-deoxy-b-D-ribofuranosyl)purine, known for its potent antiviral properties, serves as an essential nucleoside analog in the field of biomedicine. Aiming to combat purine nucleoside phosphorylase (PNP)-deficient T-cell leukemias, this compound showcases remarkable efficacy. Furthermore, its therapeutic potential extends to viral infections like HIV and herpes. As a pharmacological tool, this compound holds immense value in investigating PNP-related diseases and delving into potential therapeutic strategies. Synonyms: N-Benzyl-2'-deoxyadenosine; n6-benzyl-2'-deoxyadenosine; 2'-Deoxy-N6-benzyladenosine; 6-Benzylamino-9-(2'-deoxy-b-D-ribofuranosyl)purine. Molecular formula: C17H19N5O3. Mole weight: 341.36. | |
| 7-Deaza-2'-deoxyadenosine | It is a purine nucleoside phosphorylase inhibitor. Synonyms: 4-Amino-7-(2-deoxy-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine; 2'-Deoxytubercidin; Deoxytubercidin; 7-Deazadeoxyadenosine; (2R,3S,5R)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol; 2'-deoxy-7-deazaadenosine. Grades: ≥95%. CAS No. 60129-59-1. Molecular formula: C11H14N4O3. Mole weight: 250.25. | |
| 8-Aminoguanosine | A potent inhibitor of purine nucleoside phosphorylase. Uses: A potent inhibitor of purine nucleoside phosphorylase. Synonyms: 2,8-Diaminoinosine; NSC 90390. Grades: 98%. CAS No. 3868-32-4. Molecular formula: C10H14N6O5. Mole weight: 298.26. | |
| 8-Aminoguanosine (2,8-Diaminoinosine) | A potent inhibitor of purine nucleoside phosphorylase. Group: Biochemicals. Alternative Names: 2,8-Diaminoinosine. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 8-Aza-5'-AMP | 8-Aza-5'-AMP, a nucleoside analog, has been widely employed in exploring the activity of purine nucleoside phosphorylase (PNP) and its role in immune system functionality. Moreover, it maintains immense potential for conducting experiments on T-cell depletion and treating severe ailments like autoimmune diseases and cancer. Synonyms: 8- Azaadenosine- 5'- O- monophosphate. Molecular formula: C9H13N6O7P (free acid). Mole weight: 348.2 (free acid). | |
| 8-Azaguanosine | It is a substrate of purine nucleoside phosphorylase (PNP)?. Synonyms: Azaguanosine; NSC 46788; NSC 130283; 7H-1,2,3-Triazolo(4,5-d)pyrimidin-7-one, 5-amino-3,4-dihydro-3-beta-D-ribofuranosyl-; 5-Amino-3,6-dihydro-3-β-D-ribofuranosyl-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one. Grades: ≥95%. CAS No. 2133-80-4. Molecular formula: C9H12N6O5. Mole weight: 284.23. | |
| 9-Deazaguanine | A nucleoside analog as potent inhibitor of purine nucleoside phosphorylase. Group: Biochemicals. Alternative Names: 2-Amino-1,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one; NSC 344522. Grades: Highly Purified. CAS No. 65996-58-9. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| aldose-1-phosphate nucleotidyltransferase | The enzyme works on a variety of α-D-aldose 1-phosphates and β-L-aldose 1-phosphates (which have the same anomeric configuration as the former; see 2-Carb-6.2). Group: Enzymes. Synonyms: sugar-1-phosphate nucleotidyltransferase; NDPaldose phosphorylase; glucose 1-phosphate inosityltransferase; NDP sugar phosphorylase; nucleoside diphosphosugar phosphorylase; sugar phosphate nucleotidyltransferase; nucleoside diphosphate sugar:orthophosphate nucleotidyltransferase; sugar nucleotide phosphorylase; NDP:aldose-1-phosphate nucleotidyltransferase. Enzyme Commission Number: EC 2.7.7.37. CAS No. 9033-61-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3248; aldose-1-phosphate nucleotidyltransferase; EC 2.7.7.37; 9033-61-8; sugar-1-phosphate nucleotidyltransferase; NDPaldose phosphorylase; glucose 1-phosphate inosityltransferase; NDP sugar phosphorylase; nucleoside diphosphosugar phosphorylase; sugar phosphate nucleotidyltransferase; nucleoside diphosphate sugar:orthophosphate nucleotidyltransferase; sugar nucleotide phosphorylase; NDP:aldose-1-phosphate nucleotidyltransferase. Cat No: EXWM-3248. | |
| AMP phosphorylase | The enzyme from archaea is involved in AMP metabolism and CO2 fixation through type III RubisCO enzymes. The activity with CMP and UMP requires activation by cAMP. Group: Enzymes. Synonyms: AMPpase; nucleoside monophosphate phosphorylase; deoA (gene name). Enzyme Commission Number: EC 2.4.2.57. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2687; AMP phosphorylase; EC 2.4.2.57; AMPpase; nucleoside monophosphate phosphorylase; deoA (gene name). Cat No: EXWM-2687. | |
| CI 972 | This active molecular is a potent purine nucleoside phosphorylase inhibitor and a T cell-selective immunosuppressive agent. CI-972 inhibited proliferation of human MOLT-4 (T cell) and not MGL-8 (B cell) lymphoblasts with respective IC50s of 3.0 and greater than 50 microM when tested with 10 microM 2'-deoxyguanosine. In Apr 1996, Immunological Disorders section added to drug profile and Immunological disorders in USA was discontinued. Uses: Immunological disorders; transplant rejection. Synonyms: CI 972; CI972; CI-972. 4H-Pyrrolo(3,2-d)pyrimidin-4-one, 2,6-diamino-1,5-dihydro-7-(3-thienylmethyl)-, monohydrochloride. Grades: 98%. CAS No. 115787-68-3. Molecular formula: C11H12ClN5OS. Mole weight: 297.76. | |
| Forodesine | Forodesine (BCX-1777) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC 50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine could induce apoptosis in leukemic cells by increasing the dGTP levels [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BCX-1777; Immucillin-H. CAS No. 209799-67-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-16210. | |
| FORODESINE | Forodesine (BCX-1777) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine could induce apoptosis in leukemic cells by increasing the dGTP levels. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: White to Yellow Solid. CAS No. 209799-67-7. Molecular formula: C11H14N4O4. Mole weight: 266.26. Purity: 0.95. Canonical SMILES: O=C1C(NC=C2[C@@H]3N[C@H](CO)[C@@H](O)[C@H]3O)=C2NC=N1. Product ID: ACM209799677. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Forodesine hydrochloride | Forodesine hydrochloride (BCX-1777 hydrochloride) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC 50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine hydrochloride is a potent human lymphocyte proliferation inhibitor. Forodesine hydrochloride could induce apoptosis in leukemic cells by increasing the dGTP levels [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BCX-1777 hydrochloride; Immucillin-H hydrochloride. CAS No. 284490-13-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-16209. | |
| Forodesine hydrochloride | Forodesine hydrochloride is the hydrochloride salt of Forodesine. Forodesine, also called as BCX-1777 or Immucillin-H, is an orally bioavailable inhibior of mammalian purine nucleoside phosphorylase (PNP). Forodesine is undergoing a phase II trial to trea. Synonyms: 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]-1,5-dihydropyrrolo[3,2-d]pyrimidin-4-one;hydrochloride1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-iminoribitolBCX-1777; BCX1777BCX1777forodesineImmH cpdimmucillin Himmucillin-H. CAS No. 284490-13-7. Molecular formula: C11H15ClN4O4. Mole weight: 302.715. | |
| N-Acetyl-guanosine 2',3',5'-Triacetate 6-(N,N-Diphenylcarbamate) | N-Acetyl-guanosine 2',3',5'-Triacetate 6-(N,N-Diphenylcarbamate) is an intermediate in the synthesis of 8-Aminoguanosine. 8-Aminoguanosine is a potent inhibitor of purine nucleoside phosphorylase. Synonyms: N-Acetyl-guanosine 2',3',5'-Triacetate 6-(Diphenylcarbamate). CAS No. 112233-75-7. Molecular formula: C31H30N6O10. Mole weight: 646.6. | |
| Native Bacillus stearothermophilus Polynucleotide Phosphorylase | Polynucleotide phosphorylase (PNPase) is a bifunctional enzyme with a phosphorolytic 3' to 5' exoribonuclease activity and a 3'-terminal oligonucleotide polymerase activity. It is also involved in mRNA processing and degradation in bacteria, plants, and humans. Applications: The enzyme is useful for the preparation of polyribonucleotide. Group: Enzymes. Synonyms: PNPase; nucleoside diphosphate:polynucleotidyl transferase; polyribonucleotide nucleotidyltransferase; polynucleotide phosphorylase; polyribonucleotide phosphorylase; EC 2.7.7.8; 9014-12-4. Enzyme Commission Number: EC 2.7.7.8. CAS No. 9014-12-4. Polynucleotide phosphorylase. Mole weight: 300,000 - 340,000; Subunit molecular weight : ca. 85,000. Appearance: Lyophilized. Storage: Stable at -20 °C for at least one year. Source: Bacillus stearothermophilus. PNPase; nucleoside diphosphate:polynucleotidyl transferase; polyribonucleotide nucleotidyltransferase; polynucleotide phosphorylase; polyribonucleotide phosphorylase; EC 2.7.7.8; 9014-12-4. Cat No: NATE-1908. | |
| Native Microbial Xanthine Oxidase | Xanthine oxidase is a molybdenum-containing enzyme that is found in the cytosol, and may be strongly inhibited by flavonoids. It plays a vital role in the metabolism of some drugs, as well as purines and pyrimidines. It is also known to be a biological source of reactive oxygen species. Xanthine oxidase was shown to be involved in the reduction of cytochrome c by the generation of superoxide anions following the oxidation of xanthine. These free radicals are responsible for reducing cytochrome c. Allopurinol is a synthetic drug show to inhibit xanthine oxidase. Applications: This enzyme is useful for enzymatic determination of inorganic phosphorus, 5?-nucleotidase and adenosine deaminase when coupled with purine-nucleoside phosphorylase and uricase. Group: Enzymes. Synonyms: Xanthine oxidase; XO; xanthine oxidoreductase; EC 1.17. Enzyme Commission Number: EC 1.17.3.2. CAS No. 9002-17-9. XAO. Mole weight: mol wt ~160 kDa. Activity: > 7 units/mg solid. Storage: -20°C. Form: Lyophilized powder containing BSA and sodium glutamate as stabilizers. Source: Microbial. Xanthine oxidase; XO; xanthine oxidoreductase; EC 1.17.3.2; 9002-17-9; XOD; Xanthine:oxygen oxidoreductase; hypoxanthine oxidase; hypoxanthine:oxygen oxidoreductase; Schardinger enzyme; hypoxanthine-xanthine oxidase; xanthine:O2 oxidoreductase; xanthine:xanthine oxidase. Cat No: NATE-0733. | |
| Native Microorganism Xanthine oxidase | Xanthine oxidase is a form of xanthine oxidoreductase, a type of enzyme that generates reactive oxygen species. These enzymes catalyze the oxidation of hypoxanthine to xanthine and can further catalyze the oxidation of xanthine to uric acid. These enzymes play an important role in the catabolism of purines in some species, including humans. Applications: This enzyme is useful for enzymatic determination of inorganic phosphorus, 5'-nucleotidase and adenosine deaminase when coupled with purine-nucleoside phosphorylase and uricase. Group: Enzymes. Synonyms: EC 1.1.3.22; Xanthine oxidase; XO; XAO. Enzyme Commission Number: EC 1.1.3.22. CAS No. 9054-84-6. XAO. Mole weight: approx. 160 kDa. Activity: Grade? 10U/mg-solid or more. Stability: Stable at-20°C for at least year. Appearance: Reddish brown amorphous powder, lyophilized. Source: Microorganism. EC 1.1.3.22; Xanthine oxidase; XO; XAO. Cat No: DIA-218. | |
| Polynucleotide Phosphorylase from Escherichia coli, Recombinant | Polynucleotide phosphorylase (PNPase) is a bifunctional enzyme with a phosphorolytic 3' to 5' exoribonuclease activity and a 3'-terminal oligonucleotide polymerase activity. It is also involved in mRNA processing and degradation in bacteria, plants, and humans. Applications: Polynucleotide phosphorylase (pnp) has been used in a study to show that spontaneous mutations resulting from replication errors are reduced in a pnp-deficient strain. it has also been used in a study to show that the absence of pnpase makes e. coli cells sensitive to uv, which suggests pnp has a role in survival of uv damage. Group: Enzymes. Synonyms: PNPase; nucleoside diphosphate:polynucleotidyl transferase; polyribonucleotide nucleotidyltransferase; polynucleotide phosphorylase; polyribonucleotide phosphorylase; EC 2.7.7.8; 9014-12-4. Enzyme Commission Number: EC 2.7.7.8. CAS No. 9014-12-4. Polynucleotide phosphorylase. Storage: -70°C. Form: Supplied as a solution in 20 mM Hepes buffer pH 7.9, 0.1 mM EDTA, 2 mM DTT, 12.5 mM MgCl2, 200 mM KCl, 21.4% (w/v) Glycerol. Source: E. coli. Species: Escherichia coli. PNPase; nucleoside diphosphate:polynucleotidyl transferase; polyribonucleotide nucleotidyltransferase; polynucleotide phosphorylase; polyribonucleotide phosphorylase; EC 2.7.7.8; 9014-12-4. Cat No: NATE-0608. | |
| Polynucleotide phosphorylase from Human, Recombinant | Polynucleotide phosphorylase (PNPase) is a bifunctional enzyme with a phosphorolytic 3' to 5' exoribonuclease activity and a 3'-terminal oligonucleotide polymerase activity. It is also involved in mRNA processing and degradation in bacteria, plants, and humans. Group: Enzymes. Synonyms: PNPase; nucleoside diphosphate:polynucleotidyl transferase; polyribonucleotide nucleotidyltransferase; polynucleotide phosphorylase; polyribonucleotide phosphorylase; EC 2.7.7.8; 9014-12-4. Enzyme Commission Number: EC 2.7.7.8. CAS No. 9014-12-4. Polynucleotide phosphorylase. Storage: -70°C. Form: supplied as a solution in 20 mM HEPES buffer, pH 7.9, with 0.1 mM EDTA, 2 mM DTT, 12.5 mM MgCl2, ~130 mM KCl, and 20% (w/v) glycerol. Source: E. coli. Species: Human. PNPase; nucleoside diphosphate:polynucleotidyl transferase; polyribonucleotide nucleotidyltransferase; polynucleotide phosphorylase; polyribonucleotide phosphorylase; EC 2.7.7.8; 9014-12-4. Cat No: NATE-0609. | |
| Polynucleotide phosphorylase from Synechocystis sp., Recombinant | Polynucleotide phosphorylase (PNPase) is a bifunctional enzyme with a phosphorolytic 3' to 5' exoribonuclease activity and a 3'-terminal oligonucleotide polymerase activity. It is also involved in mRNA processing and degradation in bacteria, plants, and humans. Polynuclotide phosphorlyase in spinach chloroplasts acts as a exonuclease and a poly (a) polymerase. Applications: Polynucleotide phosphorylase has been used in a study to discover that a major function of pnpase is the synthesis of cdp. it has also been used in a study to investigate the enzyme responsible for rna 3?-tail synthesis in s. coelicolor. Group: Enzymes. Synonyms: PNPase; nucleoside diphosphate:polynucleotidyl transferase; polyribonucleotide nucleotidyltransferase; polynucleotide phosphorylase; polyribonucleotide phosphorylase; EC 2.7.7.8; 9014-12-4. Enzyme Commission Number: EC 2.7.7.8. CAS No. 9014-12-4. Polynucleotide phosphorylase. Storage: -70°C. Source: E. coli. Species: Synechocystis sp. PNPase; nucleoside diphosphate:polynucleotidyl transferase; polyribonucleotide nucleotidyltransferase; polynucleotide phosphorylase; polyribonucleotide phosphorylase; EC 2.7.7.8; 9014-12-4. Cat No: NATE-0610. | |
| polyribonucleotide nucleotidyltransferase | ADP, IDP, GDP, UDP and CDP can act as donors. Group: Enzymes. Synonyms: polynucleotide phosphorylase; PNPase; nucleoside diphosphate:polynucleotidyl transferase; polyribonucleotide nucleotidyltransferase; polynucleotide phosphorylase; polyribonucleotide phosphorylase. Enzyme Commission Number: EC 2.7.7.8. CAS No. 9014-12-4. Polynucleotide phosphorylase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3292; polyribonucleotide nucleotidyltransferase; EC 2.7.7.8; 9014-12-4; polynucleotide phosphorylase; PNPase; nucleoside diphosphate:polynucleotidyl transferase; polyribonucleotide nucleotidyltransferase; polynucleotide phosphorylase; polyribonucleotide phosphorylase. Cat No: EXWM-3292. | |
| S-methyl-5'-thioadenosine phosphorylase | Also acts on 5'-deoxyadenosine and other analogues having 5'-deoxy groups. Group: Enzymes. Synonyms: 5'-deoxy-5'-methylthioadenosine phosphorylase; MTA phosphorylase; MeSAdo phosphorylase; MeSAdo/Ado phosphorylase; methylthioadenosine phosphorylase; methylthioadenosine nucleoside phosphorylase; 5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase; S-methyl-5-thioadenosine phosphorylase; S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-α-D-ribosyl-transferase. Enzyme Commission Number: EC 2.4.2.28. CAS No. 61970-06-7. MTAP. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2655; S-methyl-5'-thioadenosine phosphorylase; EC 2.4.2.28; 61970-06-7; 5'-deoxy-5'-methylthioadenosine phosphorylase; MTA phosphorylase; MeSAdo phosphorylase; MeSAdo/Ado phosphorylase; methylthioadenosine phosphorylase; methylthioadenosine nucleoside phosphorylase; 5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase; S-methyl-5-thioadenosine phosphorylase; S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-α-D-ribosyl-transferase. Cat No: EXWM-2655. | |
| S-methyl-5'-thioadenosine phosphorylase from Human, Recombinant | MTAP expression is crucial for the catabolism of methylthioadenosine, which is a by-product of polyamine biosynthesis in the methionine salvage pathway. Protein expression is decreased by homozygous deletion and promoter hypermethylation. N-terminal gst-tagged 57 kda protein containing amino acids 2-end. Applications: S-methyl-5?-thioadenosine phosphorylase human (mtap) is an enzyme used in cancer research that is deficient in many types of cancer. decreased mtap expression may be used as a potential indicator of disease progression of gastrointestinal stromal tumors. mtap may be a used to develop potential therapeutic strategies for hepat ocellular carcinoma ...CAS No. 61970-06-7. MTAP. Mole weight: 57 kDa. Storage: -70°C. Form: Supplied as a solution in 25 mM Tris-HCl, pH 8.0,100 mM NaCl, 0.05% Tween-20, 10% glycerol,and 3 mM DTT. Source: E. coli. Species: Human. S-methyl-5'-thioadenosine phosphorylase; EC 2.4.2.28; 5'-deoxy-5'-methylthioadenosine phosphorylase; MTA phosphorylase; MeSAdo phosphorylase; MeSAdo/Ado phosphorylase; methylthioadenosine phosphorylase; methylthioadenosine nucleoside phosphorylase; 5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase; S-methyl-5-thioadenosine phosphorylase; S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-α-D-ribosyl-transferase; MTAP. Cat No: NATE-0462. | |
| thymidine phosphorylase | The enzyme in some tissues also catalyses deoxyribosyltransferase reactions of the type catalysed by EC 2.4.2.6, nucleoside deoxyribosyltransferase. Group: Enzymes. Synonyms: pyrimidine phosphorylase; thymidine-orthophosphate deoxyribosyltransferase; animal growth regulators, blood platelet-derived endothelial cell growth factors; blood platelet-derived endothelial cell growth factor; deoxythymidine phosphorylase; gliostatins; pyrimidine deoxynucleoside phosphorylase; thymidine:phosphate deoxy-D-ribosyltransferase. Enzyme Commission Number: EC 2.4.2.4. CAS No. 9030-23-3. Thymidine Phosphorylase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2668; thymidine phosphorylase; EC 2.4.2.4; 9030-23-3; pyrimidine phosphorylase; thymidine-orthophosphate deoxyribosyltransferase; animal growth regulators, blood platelet-derived endothelial cell growth factors; blood platelet-derived endothelial cell growth factor; deoxythymidine phosphorylase; gliostatins; pyrimidine deoxynucleoside phosphorylase; thymidine:phosphate deoxy-D-ribosyltransferase. Cat No: EXWM-2668. | |
| Thymidine Phosphorylase from Escherichia coli, Recombinant | An enzyme that catalyzes the reversible conversion of thymidine to thymine. Thymidine phosphorylase is part of the pyrimidine nucleoside salvage pathway. This pathway allows pyrimidine bases to be recycled for nucleotide biosynthesis, while the pentose 1-phosphates are converted to intermediates of the pentose phosphate shunt and glycolysis. The E. coli thymidine phosphorylase shares 40% sequence homology with the human sequence, which has been found to be identical to the angiogenic agent platelet-derived endothelial growth factor. The purified E. coli enzyme has been shown to stimulate blood vessel growth in chick chorioallantoic membrane assays. Applications: ...hosphate deoxy-D-ribosyltransferase; EC 2.4.2.4; 9030-23-3. Enzyme Commission Number: EC 2.4.2.4. CAS No. 9030-23-3. Thymidine Phosphorylase. Activity: Type I, > 900 units/mL, aseptically filled; Type II, > 500 units/mL. Storage: 2-8°C. Form: buffered aqueous solution, Solution in 0.5 M potassium phosphate containing 2 mM uracil, 0.02% sodium azide and bovine serum albumin. Source: E. coli. Species: Escherichia coli. thymidine phosphorylase; pyrimidine phosphorylase; thymidine-orthophosphate deoxyribosyltransferase; animal growth regulators, blood platelet-derived endothelial cell growth factors; blood platelet-derived endothelial cell growth factor; deoxythymidi | |
| Ulodesine | Ulodesine, also known as BCX4208, is a purine nucleoside phosphorylase (PNP) inhibitor in development as a once-daily oral, chronic treatment for gout. Ulodesine is currently being developed by Biocryst. Ulodesine acts upstream of xanthine oxidase in the purine metabolism pathway to reduce the production of serum uric acid (sUA). Ulodesine has an IC(50) of 0.5 nM to PNP. BCX-4208 is currently undergoing early clinical investigation in psoriasis and gout. (last update: ). Synonyms: BCX4208; BCX 4208; BCX-4208; DADMe-immucillin H. CAS No. 548486-59-5. Molecular formula: C12H16N4O3. Mole weight: 264.28. | |
| Ulodesine | Ulodesine, also known as BCX4208, is a purine nucleoside phosphorylase (PNP) inhibitor in development as a once-daily oral, chronic treatment for gout. Ulodesine is currently being developed by Biocryst. Ulodesine acts upstream of xanthine oxidase in the purine metabolism pathway to reduce the production of serum uric acid (sUA). Ulodesine has an IC(50) of 0.5 nM to PNP. BCX-4208 is currently undergoing early clinical investigation in psoriasis and gout. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BCX4208, BCX 4208, BCX-4208, Ulodesine, DADMe-immucillin H. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 548486-59-5. Molecular formula: C12H16N4O3. Mole weight: 264.28. Purity: >98%. IUPACName: 7-(((3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl)methyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one. Canonical SMILES: O=C1C(NC=C2CN3C[C@H](O)[C@@H](CO)C3)=C2N=CN1. Product ID: ACM548486595. Alfa Chemistry ISO 9001:2015 Certified. | |
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