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| Product | Description | |
|---|---|---|
| O-1602 | O-1602. Group: Biochemicals. Grades: Purified. CAS No. 317321-41-8. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| O-1602 | O-1602 is an agonist of GPR55 (G protein-coupled receptor 55). O-1602 reduces the number and activation of hippocampal microglia induced by METH (methamphetamine). O-1602 decreases the expression levels of NLRP3 inflammasome proteins, including NLRP3, ASC and Caspase-1 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 317321-41-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107541. |  |
| O-1602 | O-1602 is an atypical analog of cannabinoid which acts as a potent and selective agonist of the cannabinoid (CB) receptor G protein-coupled 55(GPR55). Its EC50 values are 13, >30,000, and >30,000 nM for GPR55, CB1, and CB2, respectively. It reduces movement-induced firing of nociceptive C fibers in a rat model of inflammatory joint pain. It also decreases IL-6 and TNF-α levels and myeloperoxidase activities in the plasma, lungs, and pancreas in a mouse model of acute pancreatitis. It reduces growth of Mz-ChA-1, HuCCT-1, CCLP-1, and SG231 cholangiocarcinoma cells at a concentration of 50 μM in vitro. It increases calcium mobilization and lipogenesis in 3T3-L1 adipocytes in a dose-dependent manner and increases food intake and fat mass in rats. It induces activation of RhoA, cdc42 and rac1. Synonyms: O-1602; O 1602; O1602; 5-Methyl-4-[(1R,6R)-3-methyl-6-(1-cyclohexen-1-yl]-1,3-benzenediol. Grades: ≥98% by HPLC. CAS No. 317321-41-8. Molecular formula: C17H22O2. Mole weight: 258.36. |  |
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