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| Product | Description | |
|---|---|---|
| OAC1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| OAC1 | OAC1 is an octamer-binding transcription factor 4 (Oct4) activator. It enhances reprogramming efficiency of iPSC and accelerates the reprogramming process. Synonyms: BAS 00287861; OAC-1; N-1H-pyrrolo[2,3-c]pyridin-5-ylbenzamide. Grades: >98%. CAS No. 300586-90-7. Molecular formula: C14H11N3O. Mole weight: 237.26. |  |
| iPSC Induction Enhancer II, OAC1 N-(1H-Pyrrolo[2,3-c]pyridin-5-yl)benzamide, Induced Pluripotent Stem Cells Induction Enhancer II, Oct4-Activating Compound 1) | A cell-permeable pyrrolopyridinyl-benzamide compound that is reported to enhance the efficiency of 4F/4TF-induced iPSC generation from MEFs cultured in either feeder cell-containing ESC media or in feeder-/serum-free iSF1 media (1uM OAC1 treatment starts 48h after viral transduction). OCA1 is shown to increase cellular Oct4, Nanog, Sox2, and Tet1 mRNA levels via a yet unidentified mechanism, although OAC1 is reported not affect Oct4 promoter methylation, cellular Wnt signaling, or p53 and p21 mRNA levels. Six other iPSC reprogramming improving reagents, AM580, AzaC, BIX-01294, Tranylcypromine, VPA, and Vitamin C, in comparison, do not exhibit Oct4 and Nanog promoters enhancing activity, while BIO is demonstrated to be 3.8- and 6-fold less potent than OAC1, respectively, in inducing Oct4 and Nanog transcription. Group: Biochemicals. Grades: Highly Purified. CAS No. 300586-90-7. Pack Sizes: 25mg. Molecular Formula: C??H??N?O, Molecular Weight: 237.3. US Biological Life Sciences. |  Worldwide |
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