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Latanoprost Latanoprost eye solution is a medication administered into the eyes to control the progression of glaucoma or ocular hypertension by reducing intraocular pressure (IOP). It is a prostaglandin analogue (more specifically an analogue of prostaglandin F2α) that lowers the pressure by increasing the outflow of aqueous fluid from the eyes through the uveoscleral tract. Latanoprost is an isopropyl ester prodrug, meaning it is inactive until it is hydrolyzed by esterases in the cornea to the biologically active acid.Latanoprost was invented by Johan W. Stjernschantz and Bahram Resul, employees of the Pharmacia Corporation of Uppsala, Sweden. It is on the World Health Organizations List of Essential Medicines, a list of the most important medication needed in a basic health system. It is also known by the brand name of Xalatan manufactured by Pfizer. Annual sales are approximately $1.6 billion. The patent for latanoprost expired in March 2011, and at least one generic version is now widely available in the U.S. Alternative Names: Isopropyl (5Z,9Α,11Α,15R)-9,11,15-Trihydroxy-17-Phenyl-18,19,20-Trinor-Prost-5-En-1-Oate. CAS No. 130209-82-4. Molecular formula: C26H40O5. Mole weight: 432.59. Appearance: Oil. Purity: 0.98. Canonical SMILES: CC (C)OC (=O)CCC/C=C\\C[C@H]1[C@H] (C[C@H] ([C@@H]1CC[C@H] (CCC2=CC=CC=C2)O)O)O. Density: 1.093 g/cm³. Catalog: ACM130209824. Alfa Chemistry.
tert-Butyl 14- (N-boc-amino)-1-[3- (mercaptocarbamoyl)phenoxy]-13, 15-dioxo-3, 6, 9-trioxa-12, 16-diazanonadecan-19-oate Heterocyclic Organic Compound. Alternative Names: tert-Butyl 14- (N-Boc-amino)-1-[3- (mercaptocarbamoyl)phenoxy]-13, 15-dioxo-3, 6, 9-trioxa- 12,16-diazanonadecan-19-oate. CAS No. 1076199-60-4. Molecular formula: C30H48N4O11S. Mole weight: 672.78732. Appearance: Clear Oil. Catalog: ACM1076199604. Alfa Chemistry. 4
tert-Butyl 14-(N-boc-amino)-1-[3-(methoxycarbonyl)phenoxy]-13, 15-dioxo-3, 6, 9-trioxa-12, 16-diazanonadecan-19-oate Heterocyclic Organic Compound. Alternative Names: tert-Butyl 14-(N-Boc-amino)-1-[3-(methoxycarbonyl)phenoxy]-13, 15-dioxo-3, 6, 9-trioxa- 12,16-diazanonadecan-19-oate. CAS No. 1076199-61-5. Molecular formula: C31H49N3O12. Mole weight: 655.73366. Appearance: Yellow Oil. Purity: 0.96. IUPACName: methyl 3- [2- [2- [2- [2- [ [2- [ (2-methylpropan-2-yl) oxycarbonylamino] -3- [ [3- [ (2-methylpropan-2-yl) oxy] -3-oxopropyl] amino] -3-oxopropanoyl] amino] ethoxy] ethoxy] ethoxy] ethoxy] benzoate. Canonical SMILES: CC (C) (C)OC (=O)CCNC (=O)C (C (=O)NCCOCCOCCOCCOC1=CC=CC (=C1)C (=O)OC)NC (=O)OC (C) (C)C. Catalog: ACM1076199615. Alfa Chemistry. 4

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