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| Product | Description | |
|---|---|---|
| OBA-09 | OBA-09 is a novel multimodal neuroprotective agent. It is an ester of pyruvate and salicylic acid that acts as a multi-functional agent to protect against ischemic damages to the brain. It leads to reduction of infarct volume and also accelerates the recovery of behavioral and neurological deficits. It may be used in cell signaling studies. It shows robust protective effects in the postischemic brain. It exhibited antioxidative effects in the postischemic brain, which was evidenced by remarkable reduction of lipid peroxidation and 4-hydroxy-2-nonenal staining in OBA-09-administered animals. It was capable of scavenging hydroxyl radical in cell-free assays. It exerts anti-excitotoxic and anti-Zn2+-toxic functions. It has a potent therapeutic potential as a multimodal neuroprotectant in the postischemic brain. Uses: Oba-09 acts as a multi-functional agent to protect against ischemic damages to the brain. it leads to reduction of infarct volume and also accelerates the recovery of behavioral and neurological deficits. it may be used in cell signaling studies. Synonyms: OBA-09; OBA 09; OBA09; O-Pyruvoylsalicylic acid;2-(1,2-Dioxopropoxy)benzoic acid hydrate;2-((2-Oxopropanoyl)oxy)benzoic acid;2-(2-oxopropanoyloxy)benzoic acid. Grades: >98%. CAS No. 856095-68-6. Molecular formula: C10H8O5. Mole weight: 208.17. |  |
| OBA-09 hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Neuroprotectant, OBA-09 (2- (2-Oxopropanoyloxy) Benzoic Acid) | A brain-permeable ester of pyruvate and salicylic acid that exhibits anti-oxidative and anti-excitotoxic properties. Following its uptake by the brain tissue, it releases pyruvate and salicylic acid via ester hydrolysis (t1/2 of 43 min in serum). Exerts strong neuroprotective effects in the post-ischemic brain and significantly reduces infarct volume (27% and 65% reduction in 6 and 12 hours following i.v. administration of 10mg/kg in a rat model). Also, blocks Zn2+-induced neuronal cell death. Its neuroprotective effects are attributed to its ability to prevent NAD- and ATP-depletion in post-ischemic brain and suppression of NF-kB activity by reducing IkB-a degradation. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
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