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| Product | Description | |
|---|---|---|
| Oclacitinib | Oclacitinib, also known as PF03394197, is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Oclacitinib inhibited JAK family members by 50% at concentrations (IC50 's) ranging from 10 to 99 nM and did not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000 nm). Oclacitinib was most potent at inhibiting JAK1 (IC50 = 10 nm). Oclacitinib also inhibited the function of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31) at IC50 's ranging from 36 to 249 nm. Oclacitinib had minimal effects on cytokines that did not activate the JAK1 enzyme in cells (erythropoietin, granulocyte/macrophage colony-stimulating factor, IL-12, IL-23; IC50 's > 1000 nm). These results demonstrate that oclacitinib is a targeted therapy that selectively inhibits JAK1-dependent cytokines involved in allergy, inflammation, and pruritus and suggests these are the mechanisms by which oclacitinib effectively controls clinical signs associated with allergic skin disease in dogs. Synonyms: Cyclohexanemethanesulfonamide, N-methyl-4-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-, trans-; trans-N-Methyl-4- (methyl-7H-pyrrolo[2, 3-d]pyrimidin-4-ylamino) cyclohexanemethanesulfonamide; JAKi; PF 03394197. Grades: 98%. CAS No. 1208319-26-9. Molecular formula: C15H23N5O2S. Mole weight: 337.44. |  |
| Oclacitinib | Oclacitinib is a novel JAK inhibitor. Oclacitinib is most potent at inhibiting JAK1 ( IC 50 =10 nM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-03394197. CAS No. 1208319-26-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13577. |  |
| Oclacitinib Maleate | Oclacitinib maleate was the first selective Janus kinase (JAK) inhibitor to be developed for dogs. Oclacitinib is most potent at inhibiting JAK1 (IC50=10 nM). Synonyms: Cyclohexanemethanesulfonamide, N-methyl-4-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-, trans-, (2Z)-2-butenedioate (1:x); Apoquel; Oclacitinib maleate (1:x); PF 03394197-11; trans-N-Methyl-4- (methyl-7H-pyrrolo[2, 3-d]pyrimidin-4-ylamino) cyclohexanemethanesulfonamide maleate (1:x); N-methyl-1- ( (1r, 4r) -4- (methyl (7H-pyrrolo[2, 3-d]pyrimidin-4-yl) amino) cyclohexyl) methanesulfonamide maleate. Grades: ≥95%. CAS No. 1208319-27-0. Molecular formula: C15H23N5O2S.xC4H4O4. Mole weight: 337.44 (free base). | |
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