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| Product | Description | |
|---|---|---|
| Onvansertib | NMS-1286937 is a potent, selective and orally available PLK1 inhibitor, with an IC 50 of 2 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NMS-1286937; NMS-P937. CAS No. 1034616-18-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15828. |  |
| Onvansertib | Onvansertib Inhibitor. Uses: Scientific use. Product Category: T6247. CAS No. 1034616-18-6. |  |
| NMS-1286937 | NMS1286937, also know as NMS-P937, is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor NMS-1286937 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressing tumor cells. PLK1 is a serine/threonine protein kinase crucial in the regulation of mitosis. Uses: Protein kinase inhibitors. Synonyms: PCM-075; PCM 075; PCM075; NMS1286937; NMS 1286937; NMS-1286937; NMS-P937; NMS-P-937; NMS-P 937; Onvansertib. Grades: >98%. CAS No. 1034616-18-6. Molecular formula: C24H27F3N8O3. Mole weight: 532.53. |  |
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