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| Product | Description | |
|---|---|---|
| Orexin 2 Receptor Agonist | N- [2- [3- [ [5- [3- (dimethylcarbamoyl) phenyl] -2-methoxyphenyl] sulfonylamino] anilino] ethyl] -3-methylbenzamide is an orexin 2 receptor agonist that is potentially for the treatment of narcolepsy. Synonyms: MDK-5220; MDK 5220; MDK5220. Orexin2 receptor agonist; CHEMBL3623075; N- [2- [3- [ [5- [3- (dimethylcarbamoyl) phenyl] -2-methoxyphenyl] sulfonylamino] anilino] ethyl] -3-methylbenzamide; GTPL9305; SCHEMBL18138813. Grades: ≥98%. CAS No. 1796565-52-0. Molecular formula: C32H34N4O5S. Mole weight: 586.707. |  |
| Orexin 2 Receptor Agonist | Orexin 2 Receptor Agonist is a potent selective OX2R agonist with an EC 50 of 23 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1796565-52-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19320. |  |
| Orexin 2 Receptor Agonist 2 | Orexin 2 Receptor Agonist 2 is a selective orexin 2 receptor agonist, extracted from patent WO2017135306A1, example 16 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2114324-60-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138695. | |
| 1-(tert-Butyloxycarbonyl)-3,3-difluoro-4-aminopiperidine | 1-(tert-Butyloxycarbonyl)-3,3-difluoro-4-aminopiperidine is synthetic building block for pharmaceuticals. It can be obtained from N-Benzyl- β-alanine Ethyl Ester (B232975) which is used as a reagent in organic synthesis including that of dipivaloyloxyphenyl aminopropionate β-agonist prodrugs which are used in the treatment of psoriasis. N-Benzyl- β-alanine Ethyl Ester (B232975) is also used in the synthesis of N,N'-dithiobis(N-benzyl- β-alanine) dethyl ester, which is an important intermediate of insecticide OK-135, and in synthesis of spiropiperidine-based orexin-2 receptor (OX2R) antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 1255666-48-8. Pack Sizes: 100mg, 500mg. Molecular Formula: C10H18F2N2O2, Molecular Weight: 236.26. US Biological Life Sciences. |  Worldwide |
| [Ala11,D-Leu15]-Orexin B | [Ala11,D-Leu15]-Orexin B is a selective OX2 receptor agonist with EC50 values are 0.13nM for human OX2. Grades: ≥95% by HPLC. CAS No. 532932-99-3. Molecular formula: C120H206N44O35S. Mole weight: 2857.28. | |
| Danavorexton | Danavorexton (TAK-925) is an orexin receptor agonist with brain permeability. Danavorexton induces a physiological pattern of OX2R activation in vitro to wake up sleepy mice and improve sleepiness symptoms [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TAK-925. CAS No. 2114324-48-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133898. | |
| Nalfurafine (TRK-820) | Nalfurafine is a κ-opioid receptor (KOR) agonist (EC50 = 0.05nM for human receptors expressed in CHO cell membranes).1 It is selective for κ-opioid over μ- and δ-opioid receptors (EC50s = 0.72 and 74.1nM, respectively). Nalfurafine (≥30ug/kg) reduces scratching behavior induced by chloroquine in mice, as well as locomotor activity when administered at a dose of 100ug/kg.2 In rats, nalfurafine (≥0.01mg/kg) reduces intracranial self-stimulation, lactic acid-induced stretching behavior, and scratching behavior induced by intradermal administration of serotonin.3 Nalfurafine is also an orexin 1 receptor (OX1R) antagonist (Ki = 250nM).4. Group: Biochemicals. Alternative Names: (2E)-N-[(5α,6 β)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]-3-(3-furanyl)-N-methyl-2-propenamide; TRK-820. Grades: Highly Purified. CAS No. 152657-84-6. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C28H32N2O5, Molecular Weight: 476.56. US Biological Life Sciences. | Worldwide |
| Orexin A (human, rat, mouse) | An orexin receptors agonist. It can stimulate feeding following central administration. Grades: 95%. CAS No. 205640-90-0. Molecular formula: C152H243N47O44S4. Mole weight: 3561.12. | |
| Orexin B human | An orexin receptors agonist. It can stimulate feeding following central administration. Synonyms: Human orexin B. Grades: ≥95% by HPLC. CAS No. 205640-91-1. Molecular formula: C123H212N44O35S. Mole weight: 2899.36. | |
| Orexin B (rat, mouse) | An orexin receptors agonist. It can stimulate feeding following central administration. Synonyms: Rat orexin B; Orexin B (mouse); H-Arg-Pro-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Asn-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2; L-arginyl-L-prolyl-glycyl-L-prolyl-L-prolyl-glycyl-L-leucyl-L-glutaminyl-glycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-asparagyl-glycyl-L-asparagyl-L-histidyl-L-alanyl-L-alanyl-glycyl-L-isoleucyl-L-leucyl-L-threonyl-L-methioninamide. Grades: ≥95% by HPLC. CAS No. 202801-92-1. Molecular formula: C126H215N45O34S. Mole weight: 2936.39. | |
| Orexin B, rat, mouse | Orexin B, rat, mouse (Rat orexin B) is an endogenous agonist at Orexin receptor with K i s of 420 and 36 nM for OX1 and OX2, respectively. Uses: Scientific research. Group: Peptides. Alternative Names: Rat orexin B; Orexin B (mouse). CAS No. 202801-92-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1349. | |
| OXA(17-33) | OXA(17-33) is a potent and selective orexin-1 receptor (OX1) agonist. OXA(17-33) shows a ?23-fold selectivity for the OX1 ( EC 50 =8.29 nM) over OX2 (187 nM) [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Orexin A (17-33) (human, mouse, rat, bovine). CAS No. 343268-91-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1341. | |
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