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| Product | Description | |
|---|---|---|
| Ortataxel | Ortataxel, also known as IDN5109, is novel seimsynthetic taxane with potential anticancer activity. Ortataxel is characterized by its high tolerability, antitumor efficacy, ability to overcome multidrug resistance, and oral bioavailabilty. In in vitro experiments, IDN5109 showed antiproliferative effects against HNSCC cell lines. After treatment with IDN5109, Bcl-2 and Bcl-XL were down-regulated, Bax was up-regulated, and caspase-3 was activated. After treatment with IDN5109, concentrations of both VEGF and IL-8 in the culture supernatant of HNSCC cells decreased. In in vivo experiments, the oral administration of IDN5109 showed antitumor effects against HNSCC tumor xenografts. Immunohistochemistry showed that IDN5109 inhibited tumor angiogenesis and induced apoptosis in HNSCC cells, producing a decreased blood vessel density and increased apoptosis index. On the basis of these results, IDN5109 is useful as a chemotherapeutic agent against HNSCC. Uses: Antineoplastic agents. Synonyms: Bay-59-8862, Bay 59 8862; SB-T-101131; SB T 101131; 13-(N-tert-butoxycarbonyl-beta-isobutyisoserinyl)-14-hydroxy-baccatin-1,14-carbonate. CAS No. 186348-23-2. Molecular formula: C44H57NO17. Mole weight: 871.93. |  |
| Ortataxel | Ortataxel. Uses: For analytical and research use. Group: Impurity standards. CAS No. 186348-23-2. Molecular formula: C44H57NO17. Mole weight: 871.93. Catalog: APB186348232. |  |
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