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| Product | Description | |
|---|---|---|
| Orteronel | Orteronel. Group: Biochemicals. Alternative Names: TAK-700; 6- [ (7S) -6, 7-Dihydro-7-hydroxy-5H-pyrrolo [1, 2-c] imidazol-7-yl] -N- methyl -2-naphthalene carboxamide. Grades: Highly Purified. CAS No. 566939-85-3. Pack Sizes: 5mg. Molecular Formula: C18H17N3O2, Molecular Weight: 307.35. US Biological Life Sciences. |  Worldwide |
| Orteronel | Orteronel (TAK-700) is a highly selective inhibitor of human 17,20-lyase (CYP17) with IC 50 of 38 nM, and exhibits >1000-fold selectivity over other CYPs such as 11-hydroxylase and CYP3A4 [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TAK-700. CAS No. 566939-85-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10505. |  |
| Orteronel | Orterone (TAK-700) is an orally bioavailable non-steroidal androgen synthesis inhibitor of steroid 17alpha-monooxygenase (17,20 lyase) with potential antiandrogen activity. TAK-700 binds to and inhibits the steroid 17alpha-monooxygenase in both the testes and adrenal glands, thereby inhibiting androgen production. This may decrease androgen-dependent growth signaling and may inhibit cell proliferation of androgen-dependent tumor cells. The cytochrome P450 enzyme CYP17A1 (P450C17), localized to the endoplasmic reticulum (ER), exhibits both 17alpha-hydroxylase and 17,20-lyase activities, and plays a key role in the steroidogenic pathway that produces steroidal hormones, such as progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Synonyms: TAK-700; TAK 700; TAK700. Grades: >98%. CAS No. 566939-85-3. Molecular formula: C18H17N3O2. Mole weight: 307.353. |  |
| TAK-700 | TAK-700 (Orteronel) is a potent and highly selective human 17,20-lyase inhibitor with IC50 of 38 nM, exhibits >1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). It completed two phase III clinical trials for metastatic, hormone-refractory prostate cancer but failed to extend overall survival rates, and development was voluntarily terminated as a result. Synonyms: TAK-700; TAK700; (S/R)-Orteronel; 6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide. Grades: >98%. CAS No. 426219-18-3. Molecular formula: C18H17N3O2. Mole weight: 307.35. | |
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