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| Product | Description | |
|---|---|---|
| OTS-514 | OTS-514, a quinolone derivative, is an effective TOPK inhibitor and has been found to have potential effect against Renal cancer. It is still under preclinical trials. IC50: 2.6 nM. Uses: Ots-514 is an effective topk inhibitor and has been found to have potential effect against renal cancer. Synonyms: OTS514; OTS 514; OTS-514. Grades: 98%. CAS No. 1338540-63-8. Molecular formula: C21H20N2O2S. Mole weight: 364.46. |  |
| OTS514 HCl | OTS514 is a potent TOPK (T-LAK cell-originated protein kinase) inhibitor. OTS514 exhibits growth suppressive effect on small cell lung cancer. TS514 effectively suppressed growth of SCLC cell lines (IC50 ; 0.4 ~ 42.6 nM) and led to their apoptotic cell death. Treatment with OTS514 suppressed forkhead box protein M1 (FOXM1) activity, which was involved in stemness of CSC. Furthermore, OTS514 treatment reduced CD90-positive SCLC cells and showed higher cytotoxic effect against lung sphere-derived CSC-like SCLC cells. Group: Inhibitors. Alternative Names: OTS514; OTS 514; OTS-514; OTS514 HCl; OTS514 Hydrochloride. CAS No. 2319647-76-0. Molecular formula: C21H21ClN2O2S. Mole weight: 400.92. Appearance: Solid powder. Purity: >98%. IUPACName: 9-[4-[(1R)-2-amino-1-methylethyl]phenyl]-8-hydroxy-6-methyl-thieno[2,3-c]quinolin-4(5H)-one hydrochloride. Canonical SMILES: O=C1NC2=C (C (C3=CC=C ([C@@H] (C)CN)C=C3)=C (O)C=C2C)C4=C1SC=C4. [H]Cl. Catalog: ACM2319647760. |  |
| OTS514 hydrochloride | The hydrochloride of OTS514. OTS514 is a potent TOPK (T-LAK cell-originated protein kinase) inhibitor (IC50 = 2.6 nM), with an inhibitory effect on small cell lung cancer (SCLC). It acts through suppressing growth of SCLC cell lines and inducing their apoptotic cell death. Synonyms: OTS 514 hydrochloride; OTS-514 hydrochloride; OTS514 HCl. Grades: 99.42 %. CAS No. 2319647-76-0. Molecular formula: C21H20N2O2S.HCl. Mole weight: 400.92. | |
| OTS-964 hydrochloride | OTS-964, a thienoquinolin derivative, is a TOPK inhibitor and prabably be useful in studying anticancer agent as an analogue of OTS-514. It is still under preclinical trial. IC50: 28 nM. Synonyms: OTS964; OTS 964; OTS-964. Grades: 98%. CAS No. 1338545-07-5. Molecular formula: C23H25ClN2O2S. Mole weight: 428.97. | |
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