Oxygenase Suppliers USA
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Product | Description | |
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1, 3-Bis (2- ( (benzyloxy) methyl) phenyl) isobenzofuran Quick inquiry Where to buy Suppliers range | 1, 3-Bis (2- ( (benzyloxy) methyl) phenyl) isobenzofuran is an intermediate in synthesizing 13-Fluorodibenzo[a, i]pyrene (F588440), a polycyclic aromatic hydrocarbon (PAH) thus potentially exhibiting carcinogenic properties through activation of P450 mono-oxygenase enzymes. Also, it has unique electrical and optical properties due to being a conjugated macromolecule. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 100mg, 250mg. Molecular Formula: C36H30O3. US Biological Life Sciences. | Worldwide |
1, 3-Bis (2-methylphenyl) isobenzofuran Quick inquiry Where to buy Suppliers range | 1, 3-Bis (2-methylphenyl) isobenzofuran is an intermediate in synthesizing 13-Fluorodibenzo[a, i]pyrene (F588440), a polycyclic aromatic hydrocarbon (PAH) thus potentially exhibiting carcinogenic properties through activation of P450 mono-oxygenase enzymes. Also, it has unique electrical and optical properties due to being a conjugated macromolecule. Group: Biochemicals. Grades: Highly Purified. CAS No. 252873-65-7. Pack Sizes: 500mg, 1g. Molecular Formula: C22H18O. US Biological Life Sciences. | Worldwide |
1-Bromo-2-[ (phenylmethoxy) methyl]benzene Quick inquiry Where to buy Suppliers range | 1-Bromo-2-[ (phenylmethoxy) methyl]benzene is an intermediate used in the synthesis of 13-Fluorodibenzo[a, i]pyrene (F588440), which is a polycyclic aromatic hydrocarbon (PAH) thus potentially exhibiting carcinogenic properties through activation of P450 mono-oxygenase enzymes. Also, it has unique electrical and optical properties due to being a conjugated macromolecule. Group: Biochemicals. Grades: Highly Purified. CAS No. 81395-28-0. Pack Sizes: 100mg, 250mg. Molecular Formula: C14H13BrO, Molecular Weight: 277.16. US Biological Life Sciences. | Worldwide |
[ (1-Fluoroethenyl) sulfinyl]benzene Quick inquiry Where to buy Suppliers range | [ (1-Fluoroethenyl) sulfinyl]benzene is an intermediate used in the synthesis of 13-Fluorodibenzo[a, i]pyrene (F588440), which is a polycyclic aromatic hydrocarbon (PAH) thus potentially exhibiting carcinogenic properties through activation of P450 mono-oxygenase enzymes. Also, it has unique electrical and optical properties due to being a conjugated macromolecule. Group: Biochemicals. Grades: Highly Purified. CAS No. 515863-85-1. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C8H7FOS, Molecular Weight: 170.2. US Biological Life Sciences. | Worldwide |
[ (1-Fluoroethenyl) thio]benzene Quick inquiry Where to buy Suppliers range | [ (1-Fluoroethenyl) thio]benzene is an intermediate used in the synthesis of 13-Fluorodibenzo[a, i]pyrene (F588440), which is a polycyclic aromatic hydrocarbon (PAH) thus potentially exhibiting carcinogenic properties through activation of P450 mono-oxygenase enzymes. Also, it has unique electrical and optical properties due to being a conjugated macromolecule. Group: Biochemicals. Grades: Highly Purified. CAS No. 141075-87-8. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C8H7FS, Molecular Weight: 154.199999999999. US Biological Life Sciences. | Worldwide |
2-Amino-3-methoxy-4-fluorobenzoic Acid Quick inquiry Where to buy Suppliers range | 2-Amino-3-methoxy-4-fluorobenzoic Acid is used in the synthesis of 4-Halo-3-hydroanthranilic Acids as oxygenase inhibitors in rat and human brain tissue. Group: Biochemicals. Grades: Highly Purified. CAS No. 126480-32-8. Pack Sizes: 100mg, 250mg. Molecular Formula: C8H8FNO3, Molecular Weight: 185.15. US Biological Life Sciences. | Worldwide |
2-Tolylmagnesium Bromide Quick inquiry Where to buy Suppliers range | 2-Tolylmagnesium Bromide is an intermediate used in the synthesis of 13-Fluorodibenzo[a, i]pyrene (F588440), which is a polycyclic aromatic hydrocarbon (PAH) thus potentially exhibiting carcinogenic properties through activation of P450 mono-oxygenase enzymes. Also, it has unique electrical and optical properties due to being a conjugated macromolecule. Group: Biochemicals. Grades: Highly Purified. CAS No. 932-31-0. Pack Sizes: 1g, 5g. Molecular Formula: C7H7BrMg, Molecular Weight: 195.34. US Biological Life Sciences. | Worldwide |
4-Hydroxy Diclofenac Acyl Glucuronide Quick inquiry Where to buy Suppliers range | 4-Hydroxy Diclofenac acyl glucuronide is a derivative of Diclofenac. Diclofenac is the first non-steroidal anti-inflammatory drug (NSAID) that is derived from phenylacetic acid. Diclofenac, like other NSAIDs, primarily works by targeting the cyclo-oxygenase pathway in the arachidonic acid cascade, reducing the formation of inflammation mediators in the body. Grades: 98%. Molecular formula: C20H19Cl2NO9. Mole weight: 488.27. | |
Aceclofenac Quick inquiry Where to buy Suppliers range | Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. It has higher anti-inflammatory action than conventional NSAIDs. It is a cytokine inhibitor. It works by blocking the action of a substance in the body called cyclo-oxygenase. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: Preservex; Aceclofenac; YT-919; YT 919; YT919; Airtal; Beofenac. Grades: >98%. CAS No. 89796-99-6. Molecular formula: C16H13Cl2NO4. Mole weight: 354.18. | |
Adapalene Quick inquiry Where to buy Suppliers range | Adapalene is more active than indomethacin, betamethasone valerate, tretinoin, isotretinoin or etretinate in inhibiting lipoxygease activity, but it has little activity against cyclo-oxygenase. Synonyms: ADAPALENE; Differin; Adaferin; Adapaleno; Adapalenum; CD-271; CD271; CD 271. Grades: >98%. CAS No. 106685-40-9. Molecular formula: C28H28O3. Mole weight: 412.52. | |
Auranofin Quick inquiry Where to buy Suppliers range | Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA, as an inhibitor of thioredoxin reductase (TrxR) (IC50 = 20 nM; Ki = 4 nM for the NADPH-reduced form of human cytosolic TrxR). Uses: Auranofin inhibits various leukocyte activation pathways at multiple sites. Synonyms: SKF-39162; SKF-D-39162; SKF 39162; SKF D 39162; SKFD-39162; SKFD39162; Ridaura; NSC 321521, Ridauragold thiol; Gold, [1-(thio-κS)-β-D-glucopyranose 2,3,4,6-tetraacetato](triethylphosphine)-; [1-(Thio-κS)-β-D-glucopyranose 2, 3, 4, 6-tetraacetato] (triethylphosphine)gold; Gold, (1-thio-β-D-glucopyranosato)(triethylphosphine)-, 2,3,4,6-tetraacetate; Gold, (1-thio-β-D-glucopyranose 2,3,4,6-tetraacetato-S)(triethylphosphine)-; β-D-Glucopyranose, 1-thio-, 2,3,4,6-tetraacetate, gold complex; [ (Tetra-O-acetyl-β -D-glucopyranosyl)thio] (triethylphosphine)gold; Aktil; Crisinor; Crisofin Gold Salt; Ridauran; SKF 39162D. Grades: ≥98%. CAS No. 34031-32-8. Molecular formula: C20H34AuO9PS. Mole weight: 678.49. | |
Daminozide Quick inquiry Where to buy Suppliers range | Daminozide is a highly selective inhibitor of the human 2-oxoglutarate (JmjC) histone demethylases KDM2A, PHF8, and KDM7A with IC50 values of 1.5, 0.55, and 2.1 μM, respectively. When tested for inhibition of other demethylase subfamily members (KDM3, KDM4, KDM5, KDM6) and other 2OG oxygenases (FIH, PHD2, BBOX1), daminozide was considerably less potent (IC50s > 100 μM). Daminozide is known to retard plant growth and was widely used in the 1960s for agricultural and horticultural applications to control plant size and fruit ripening before it was withdrawn because of carcinogenicity concerns. Synonyms: Alar; B 995; DMASA; SADH; Succinic Acid; Aminozide; Kylar; DIMG. Grades: >98%. CAS No. 1596-84-5. Molecular formula: C6H12N2O3. Mole weight: 160.17. | |
Flavoglaucin Quick inquiry Where to buy Suppliers range | Flavoglaucin is a natural compound isolated from marine fungus Eurotium sp. SF-5989. Flavoglaucin exhibits significant inhibitory effect on PTP1B with IC50 value of 13.4 micrometer. Flavoglaucin shows good binding affinity for human opioid or cannabinoid receptors. Flavoglaucin has anti-inflammatory effect, which inhibits inflammatory mediators via the induction of heme oxygenase-1 in lipopolysaccharide-stimulated RAW264.7 macrophages. Flavoglaucin exhibits significant radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with the IC50 value of 11.3 microM. Synonyms: 6-Heptyl-3-(3-methyl-2-butenyl)gentisaldehyde; Benzaldehyde, 2-heptyl-3,6-dihydroxy-5-(3-methyl-2-butenyl)-. Grades: 98.0%. CAS No. 523-73-9. Molecular formula: C19H28O3. Mole weight: 304.42. | |
Iguratimod Quick inquiry Where to buy Suppliers range | Iguratimod is a selective inhibitor of cyclo-oxygenase-2 (COX-2), and inhibits the production of interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor. Uses: Anti-inflammation agent. Synonyms: T 614; T-614; T614; N-(7-(Methylsulfonamido)-4-oxo-6-phenoxy-4H-chromen-3-yl)formamide; Careram; Kolbet; UNII-4IHY34Y2NV. Grades: 0.98. CAS No. 123663-49-0. Molecular formula: C17H14N2O6S. Mole weight: 374.367. | |
IOX1 Quick inquiry Where to buy Suppliers range | IOX1 is a potent and broad-spectrum inhibitor of 2OG oxygenases. Synonyms: IOX1; IOX-1; IOX 1. Grades: >98%. CAS No. 5852-78-8. Molecular formula: C10H7NO3. Mole weight: 189.17. | |
JSH-23 Quick inquiry Where to buy Suppliers range | JSH-23 is a nuclear factor-kappa B (NF-κB) nuclear translocation inhibitor. JSH-23 inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. JSH-23 treatment significantly reversed the nerve conduction and nerve blood flow deficits seen in diabetic animals. Reduction in mechanical pain threshold was also partially corrected by the treatment. Protein expression studies showed that nuclear translocation of p65/p50 subunit was inhibited by JSH-23 treatment in the sciatic nerve. The treatment also lowered the elevated IL-6, TNF-α, cyclo-oxygenase (COX-2) and inducible nitric oxide synthase (iNOS) levels/expression, indicating reduction in the inflammatory damage of the sciatic nerve. Apart from these effects, JSH-23 also increased Nrf2 and hemeoxygenase-1 (HO-1) levels which could imply its potential in increasing the strength of antioxidant defence. Synonyms: JSH-23; JSH 23; JSH23. Grades: 0.98. CAS No. 749886-87-1. Molecular formula: C16H20N2. Mole weight: 240.35. | |
Lagunamycin Quick inquiry Where to buy Suppliers range | It is produced by the strain of Str. sp. AA0310. It can inhibit 5-fat oxygenase with IC50 of 6.08 μmol/L, but dose not inhibit lipid peroxidation. It has the activity of anti-gram-positive bacteria, not anti-gram-negative bacteria. Synonyms: (E)-(-)-6-Diazo-3-methyl-4-(1,3,5-trimethyl-1-hexenyl)-2,5,7,8(1H,6H)-quinolinetetrone; 6-diazonio-4-[(E)-4,6-dimethylhept-2-en-2-yl]-3-methyl-2,7,8-trioxo-1H-quinolin-5-olate. Grades: 95%. CAS No. 150693-65-5. Molecular formula: C19H21N3O4. Mole weight: 355.39. | |
Nrf2 Activator III, TAT-14 Peptide, H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH Quick inquiry Where to buy Suppliers range | A 14-mer peptide (LQLDEETGEFLPIQ) conjugated to cell-penetrating trans-activating transcriptional activator (TAT) sequence (YGRKKRRQRRRLQ) that targets the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) binding site on Kelch-like ECH-associated protein 1 (Keap1). Competitively disrupts Nrf2-Keap1 interaction and stabilizes cytosolic Nrf2, and promotes its nuclear translocation and binding to the antioxidant response element (ARE). Exhibits anti-inflammatory properties and increases heme-oxygenase-1 gene expression (~75uM). Also shown to suppress LPS-induced TNF-a secretion in THP-1 monocytes (~ 37.5uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 1362661-34-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
OB 24 hydrochloride Quick inquiry Where to buy Suppliers range | OB 24 hydrochloride is a selective heme oxygenase 1 (HO-1) inhibitor with IC50 value of 1.9μM. It can inhibit cell proliferation in vitro, PCA tumor growth and lymph node/lung metastases in vivo. Synonyms: OB-24 hydrochloride; OB 24 hydrochloride; OB24 hydrochloride; OB-24 HCl; OB 24 HCl; OB24 HCl; 1-[[2-[2-(4-Bromophenyl)ethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazole hydrochloride. Grades: ≥98% by HPLC. CAS No. 939825-12-4. Molecular formula: C15H17BrN2O2.HCl. Mole weight: 373.67. | |
RTA-408 Quick inquiry Where to buy Suppliers range | RTA-408 is a member of the synthetic oleanane triterpenoid class of compounds and an activator of nuclear factor erythroid 2 [NF-E2]-related factor 2 (Nrf2, Nfe2l2), with potential chemopreventive activity. Upon administration, RTA 408 activates the cytoprotective transcription factor Nrf2. In turn, Nrf2 translocates to the nucleus, dimerizes with a small Maf protein (sMaf), and binds to the antioxidant response element (ARE). This induces the expression of a number of cytoprotective genes, including NAD(P)H quinone oxidoreductase 1 (NQO1), sulfiredoxin 1 (Srxn1), heme oxygenase-1 (HO1, HMOX1), superoxide dismutase 1 (SOD1), gamma-glutamylcysteine synthetase (gamma-GCS), thioredoxin reductase-1 (TXNRD1), glutathione S-transferase (GST), glutamate-cysteine ligase catalytic subunit (Gclc) and glutamate-cysteine ligase regulatory subunit (Gclm), and increases the synthesis of the antioxidant glutathione (GSH). Nrf2, a leucine zipper transcription factor, plays a key role in the maintenance of redox balance and cytoprotection against oxidative stress. Synonyms: RTA408; RTA408; RTA-408. Omaveloxolone; Propanamide, N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoro-. Grades: >98%. CAS No. 1474034-05-3. Molecular formula: C33H44F2N2O3. Mole weight: 554.723. | |
Santin Quick inquiry Where to buy Suppliers range | Santin is a flavonoid compound found in Alnus japonica and Grindelia glutinosa. It has anti-inflammatory activity and inhibits cyclo-oxygenase and 5-lipoxygenase pathways of arachidonic metabolism. Synonyms: 2-(4-Methoxyphenyl)-5,7-dihydroxy-3,6-dimethoxy-4H-1-benzopyran-4-one; 3,4',6-Trimethoxy-5,7-dihydroxyflavone; 5,7-Dihydroxy-3,6,4'-trimethoxyflavone; 6-Hydroxykaempferol 3,4',6-trimethyl ether; 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3,6-dimethoxy-2-(4-methoxyphenyl)-; Centauridin; 3-Methylbetuletol. Grades: ≥95%. CAS No. 27782-63-4. Molecular formula: C18H16O7. Mole weight: 344.32. | |
Stannsoporfin Quick inquiry Where to buy Suppliers range | Stannsoporfin (SnMP) is a porphyrin-Sn(IV) complex, is also a potent heme oxygenase inhibitor, that inhibits HO-1-mediated heme catabolism with potential medicinal application for the treatment of both neonatal jaundice and inherited hyperbilirubinemia syndromes. It was developed to possess unique structural and photophysical properties that make it a particularly potent and bioavailable in vivo inhibitor suitable for clinical use in newborns and studies to date have revealed a very favorable therapeutic profile with no significant adverse side effects. Synonyms: Tin mesoporphyrin; SNMPP; SnMP; Sn Mesoporphyrin; Stanate; Sn(IV) Mesoporphyrin IX Dichloride. CAS No. 106344-20-1. Molecular formula: C34H36Cl2N4O4Sn. Mole weight: 754.29. | |
TAT 14 Quick inquiry Where to buy Suppliers range | TAT 14 is an Nrf2 activator and inhibits Nrf2/Keap1 interaction with neuroprotective activity. TAT 14 has been shown to induce upregulation of Nrf2 pathway downstream gene expression including heme-oxygenase 1 and suppress LPS-induced TNF-α expression in THP-1 cells. Synonyms: TAT14; TAT-14; H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH; L-tyrosyl-glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-leucyl-L-glutaminyl-L-leucyl-L-alpha-aspartyl-L-alpha-glutamyl-L-alpha-glutamyl-L-threonyl-glycyl-L-alpha-glutamyl-L-phenylalanyl-L-leucyl-L-prolyl-L-isoleucyl-L-glutamine; TAT 14 Peptide (Nrf2 Activator III). Grades: ≥95%. CAS No. 1362661-34-4. Molecular formula: C137H230N48O39. Mole weight: 3173.59. | |
Tin protoporphyrin IX dichloride Quick inquiry Where to buy Suppliers range | Tin protoporphyrin IX dichloride is a potent heme oxygenase inhibitor with selectivity for HO-1 (Ki = 11 nM) over HO-2 (IC50 = 7.5 μM). Tin protoporphyrin IX dichloride is used for the prevention of hyperbilirubinemia in neonates. Synonyms: (OC-6-13)-Dichloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24]-stannate(2-) Dihydrogen. CAS No. 14325-05-4. Molecular formula: C34H32Cl2N4O4Sn. Mole weight: 750.25. | |
YS-49 Quick inquiry Where to buy Suppliers range | Anti-inflammatory agent; Antithrombotic; Antiplatelet; YS-49 protects cells from oxidant injury; induces heme oxygenase (HO-1) in endothelial cells and protects cells from oxidant injury; activator of PI3K/Akt signaling. Synonyms: YS 49; YS49. Grades: >98%. CAS No. 132836-42-1. Molecular formula: C20H20BrNO2. Mole weight: 386.28. | |
Zamicastat Quick inquiry Where to buy Suppliers range | Zamicastat is a potent and selective dopamine β-mono-oxygenase inhibitor. It prevents the Deterioration of Cardiometabolic and Inflammatory Biomarkers in a Genetic Model of Salt-sensitive Hypertension. It is used for the treatment for hypertension and heart failure. It was developed by Bial-Portela and in clinic phase 1 trails. Uses: Zamicastat is used for the treatment for hypertension and heart failure. Synonyms: 4-[2-(Benzylamino)ethyl]-3-[(3R)-6,8-difluoro-3,4-dihydro-2H-chromen-3-yl]-1H-imidazole-2-thione;(R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydro-2H-imidazole-2-thione. Grades: >98%. CAS No. 1080028-80-3. Molecular formula: C21H21F2N3OS. Mole weight: 401.48. | |
Zinc protoporphyrin IX Quick inquiry Where to buy Suppliers range | Zinc protoporphyrin IX is an endogenous metabolite formed during heme biosynthesis and a heme oxygenase inhibitor. Heme oxygenase is the enzyme producing CO, which is an activator of guanylyl cyclase and shares some chemical and biological properties of NO. Zinc protoporphyrin IX has been shown to inactivates the NOS isoforms nNOS, iNOS, and eNOS(IC50 = 0.8, 4, and 5 μM, respectively). Synonyms: 7,12-Diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid, zinc complex; Zinc protoporphyrin-9; ZnPP; Zinc 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,23-diid-2-yl]propanoic acid; Zn-Protoporphyrin IX. CAS No. 15442-64-5. Molecular formula: C34H32N4O4Zn. Mole weight: 626.03. |