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Vasoconstrictor, used as a nasal decongestant. An ingredient of Drixin. Oxymetazoline is an agonist of α1- and α2-adrenergic receptors (α1- and α2-ARs; Kds = 6, 320, and 390 nM for α1A-, α1B-, and α1D-ARs, respectively, Ki = 15 nM for α2-AR).1,2 It is also an agonist of the serotonin (5-HT) receptor subtype 5-HT1 (Kds = 4.68, 25.7, and 5.01 nM for 5-HT1A, 5-HT1B, and 5-HT1D, respectively).3 Oxymetazoline increases intracellular calcium levels in CHO cells transfected with the α1A-AR (EC50 = 40.7 nM), but does not increase it measurably in cells transfected with the α1B- or α1D-AR (EC50s = 79.4 and 240 nM, respectively).1 It acts as a partial agonist of the α2-AR in isolated perfused rat heart (IC50 = 63 nM and EC50 = 13.5 nM for norepinephrine release).4,5 Oxymetazoline also acts as an agonist and antagonist of the 5-HT1C receptor in the presence of methiothepin (Kd = 110 nM; Item No. 23138) and clonidine (Kd = 257 Group: Biochemicals. Alternative Names: 3-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-6-(1,1-dimethylethyl)-2,4-dimethylphenol Hydrochloride; 2-(4-tert-Butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline Hydrochloride; 6-tert-Butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimethylphenol Hydrochloride; Hazol; Navasin; Navisin; Nezeril; Oxylazine; Rhinofrenol; Rhinolitan; Sinerol. Grades: Highly Purified. CAS No. 2315-2-8. Pack Sizes: 100mg, 500mg, 1g, 5g. Molecular Formula: C??H??ClN?O, Molecular Weight: 296.84. US Biological Life Sciences.
An impurity of Oxymetazoline which is a selective α1 adrenergic receptor agonist and α2 adrenergic receptor partial agonist. Grades: > 95%. Molecular formula: C16H26N2O2. Mole weight: 278.4.
Oxymetazoline Impurity B
An impurity of Oxymetazoline which is a direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. Grades: > 95%. Molecular formula: C16H24N2. Mole weight: 244.38.
Oxymetazoline Impurity C
An impurity of Oxymetazoline which is a vasoconstrictor to relieve nasal congestion, used in the form of oxymetazoline hydrochloride. Grades: > 95%. Molecular formula: C14H21NO2. Mole weight: 235.33.
Oxymetazoline Impurity D
An impurity of Oxymetazoline which is a direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. Grades: > 95%. Molecular formula: C14H20O3. Mole weight: 236.31.
Oxymetazoline Impurity E
An impurity of Oxymetazoline which is a vasoconstrictor to relieve nasal congestion, used in the form of oxymetazoline hydrochloride. Grades: > 95%. Molecular formula: C14H19NO. Mole weight: 217.31.
Oxymetazoline Related Compound A
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.