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| Product | Description | |
|---|---|---|
| P005091 | P005091. Group: Biochemicals. Alternative Names: 1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]-ethanone. Grades: Highly Purified. CAS No. 882257-11-6. Pack Sizes: 10mg. Molecular Formula: C12H7Cl2NO3S2, Molecular Weight: 348.22. US Biological Life Sciences. |  Worldwide |
| P005091 | P005091 is a potent and selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 μM). P005091 induces elevated p53 and apoptosis in cancer cell lines and displays antiangiogenic activity in vivo. The deubiquitylating enzyme USP7 (HAUSP) sits at a critical node regulating the activities of numerous proteins broadly characterized as tumor suppressors, DNA repair proteins, immune responders, viral proteins, and epigenetic modulators. Aberrant USP7 activity may promote oncogenesis and viral disease making it a compelling target for therapeutic intervention. Synonyms: P005091; P-005091; P 005091; P5091; P-5091; P 5091. Grades: 0.98. CAS No. 882257-11-6. Molecular formula: C12H7Cl2NO3S2. Mole weight: 348.212. |  |
| P005091 (USP7 Inhibitor, 1-[5-[(2,3-Dichlorophenyl)thio]-4-n itro-2-thienyl]ethanone) | Selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2um). Displays little-to-no inhibition of other USP variants or proteases such as caspase, cathepsins and serine proteases; exhibits some activity at USP47. Induces elevated p53 and apoptosis in cancer cell lines; displays antiangiogenic activity in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 882257-11-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
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