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| Product | Description | |
|---|---|---|
| PACMA 31 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| PACMA 31 | PACMA 31. Group: Biochemicals. Grades: Purified. CAS No. 1401089-31-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| PACMA 31 | PACMA 31 is an irreversible, orally active protein disulfide isomerase (PDI) inhibitor with an IC50 of 10 ?M. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues[1]. PACMA 31 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1401089-31-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100433. |  |
| PACMA 31 | PACMA 31 is a protein disulfide isomerase family inhibitor as promising target for chemotherapy. It inhibits growth of ovarian cancer cells. Synonyms: PACMA 31; PACMA31; PACMA-31; N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycylglycine ethyl ester. Grades: ≥99% by HPLC. CAS No. 1401089-31-3. Molecular formula: C21H22N2O6S. Mole weight: 430.47. |  |
| CCF-642 | CCF-642 is a protein disulfide isomerase (PDI) inhibitor that exhibits 100-fold higher potency than PACMA 31 (by di-E-GSSG assay) via an alternative mode of action. CCF642 displayed potent efficacy in an aggressive syngeneic mouse model of multiple myeloma and prolonged the lifespan of C57BL/KaLwRij mice engrafted with 5TGM1-luc myeloma, an effect comparable to the first-line multiple myeloma therapeutic bortezomib. Synonyms: 3-(4-Methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone; CCF-642; CCF 642; CCF642. CAS No. 346640-08-2. Molecular formula: C15H10N2O4S3. Mole weight: 378.44. | |
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