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| Product | Description | |
|---|---|---|
| Palifosfamide | Palifosfamide is a novel DNA alkylator and the active metabolite of ifosfamide, with antitumor activity. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Isophosphoramide mustard; IPM; ZIO-201. CAS No. 31645-39-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-14798. |  |
| Palifosfamide | Palifosfamide is a synthetic mustard compound with potential antineoplastic activity. An active metabolite of ifosfamide covalently linked to the amino acid lysine for stability, palifosfamide irreversibly alkylates and cross-links DNA through GC base pairs, resulting in irreparable 7-atom inter-strand cross-links; inhibition of DNA replication and cell death follow. Unlike ifosfamide, this agent is not metabolized to acrolein or chloroacetaldehyde, metabolites associated with bladder and CNS toxicities. In addition, because palifosfamide does not require activation by aldehyde dehydrogenase, it may overcome the tumor resistance seen with ifosfamide. Synonyms: Isophosphamide mustard; Isophosphoramide mustard; IPAM; bis(2-chloroethylamino)phosphinic acid. Grades: ≥ 98%. CAS No. 31645-39-3. Molecular formula: C4H11Cl2N2O2P. Mole weight: 221.018. |  |
| Palifosfamide tromethamine | Palifosfamide tromethamine is a synthetic mustard compound with potential antineoplastic activity. It is an active metabolite of ifosfamide covalently linked to the amino acid lysine for stability. It inhibits DNA replication and cell death. It is not metabolized to acrolein or chloroacetaldehyde, metabolites associated with bladder and CNS toxicities. It may overcome the tumor resistance seen with ifosfamide. It was developed by Dekk-Tec and in clinic phase 3 with no progress. Uses: Palifosfamide tromethamine has potential antineoplastic activity. Synonyms: 2-Amino-2-(hydroxymethyl)propane-1,3-diol;Bis(2-chloroethylamino)phosphinic acid;ZIO201;ZIO-201;NSC297900;NSC-297900;N,N'-Bis(2-chloroethyl)phosphorodiamidic acid. Grades: >98%. CAS No. 1070409-31-2. Molecular formula: C8H22Cl2N3O5P. Mole weight: 342.15. | |
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