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| Product | Description | |
|---|---|---|
| Pam3CSK4 | Pam3CSK4 is a TLR 1/2 agonist and a cell-permeable, water-soluble synthetic tripalmitoylated lipopeptide that mimics the acylated amino terminus of bacterial LPs. Bacterial LPs are a family of pro-inflammatory cell wall components found in both Gram-positive and Gram-negative bacteria. Pam3CSK4 is a potent activator of the pro-inflammatory transcription factor NF-κB. It induces production of TNF-α, superoxide, NO, and IL-6, stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells, promotes differentiation of naive CD4+ T cells into Th17 cells, and enhances tyrosine protein phosphorylation and activation of ERK1/2 and MEK1/2. It is used in prevention of inflammation caused by certain bacterial infection. Synonyms: Pam3-Cys-Ser-Lys-Lys-Lys-Lys; (S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys4-OH; P3CSK4; Pam3Cys-SK4; TLR1/TLR2 Agonist I; Pam3Cys-Ser-(Lys)4; Synthetic Triacylated Lipopeptide; L-Lysine, S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-N-(1-oxohexadecyl)-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-; L-Lysine, N2-[N2-[N2-[N2-[N-[S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-N-(1-oxohexadecyl)-L-cysteinyl]-L-seryl]-L-lysyl]-L-lysyl]-L-lysyl]-; S-[2,3-Bis[(1-oxohexadecyl)oxy]propyl]-N-(1-oxohexadecyl)-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-L-lysine; P 3C; Pam3Cys-SKKKK; Pam3CysSK4. Grades: ≥95%. CAS No. 112208-00-1. Molecular formula: C81H156N10O13S. Mole weight: 1510.23. |  |
| Pam3CSK4 Biotin | Pam3CSK4 Biotin is the biotinylated Pam3CSK4. Pam3CSK4 is a synthetic tripalmitoylated lipopeptide that mimicks the acylated amino terminus of bacterial lipoproteins. Pam3CSK4 is a potent activator of the proinflammatory transcription factor NF-κB and a toll-like receptor 1/2 (TLR1/2) agonist. It stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells, and promotes differentiation of naive CD4+ T cells into Th17 cells. Synonyms: (2S, 3Z, 5S, 6Z, 8S, 9Z, 11S, 12Z, 14S, 15Z, 17R)-5, 8, 11-tris(4-aminobutyl)-4, 7, 10, 13, 16-pentahydroxy-2-(4-((Z)-(1-hydroxy-6-((Z)-(1-hydroxy-6-((Z)-(1-hydroxy-5-((3aR, 6S, 6aS)-2-hydroxy-3a, 4, 6, 6a-tetrahydro-1H-thieno[3, 4-d]imidazol-6-yl)pentylidene)amino)hexylidene); Pam3CysSerLys4. Grades: ≥95%. CAS No. 1429504-10-8. Molecular formula: C103H192N14O17S2. Mole weight: 1962.85. | |
| Pam3CSK4 (CSKKKK) | Toll-like receptor 1/2 (TLR1/2) agonist; induces production of TNF-α and IL-6 in macrophages. Stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells. Promotes differentiation of naive CD4+ T cells into Th17 cells. Group: Biochemicals. Alternative Names: CSKKKK (Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl]-Cys. Grades: Purified. CAS No. 112208-00-1. Pack Sizes: 1mg. Molecular Formula: C81H156N10O13S, Molecular Weight: 1510.24. US Biological Life Sciences. |  Worldwide |
| Pam3CSK4 TFA | Pam3CSK4 TFA is a toll-like receptor 1/2 ( TLR1/2 ) agonist with an EC 50 of 0.47 ng/mL for human TLR1/2 [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Pam3Cys-Ser-(Lys)4 TFA. CAS No. 112208-01-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1180A. |  |
| Pam3Cys-Ser-(Lys)4 3HCl (Pam3CSK4, Pam3Cys-SKKKK, (S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys4-OH) | Selective agonist of TLR1/TLR2 complex. Cell permeable, water soluble synthetic cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Potent and effective immune adjuvant. Exerts strong local response, enhances IgG2a and IgG1 titers and upregulates proinflammatory and Th1 cytokine genes. Potent activator of the proinflammatory transcription factor NF-kappaB. Activates/represses at least 140 genes involved in signal transduction and regulation of the immune response. Group: Biochemicals. Alternative Names: Pam3CSK4, Pam3Cys-SKKKK, (S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys4-OH. Grades: Highly Purified. CAS No. 112208-00-1. Pack Sizes: 2mg. US Biological Life Sciences. | Worldwide |
| TLR1/TLR2 Antagonist, CU-CPT22 (Hexyl-3,4,6-trihydroxy-2-methoxy-5-oxo-5H-benzo[7]annulene-8-carboxylate) | A cell-permeable benzotropolone compound that competes against Pam3CSK4- for TLR1/TLR2 heterodimer binding (Ki = 410nM) and selectively antagonizes against Pam3CSK4-induced RAW264.7 cellular NO production (IC50 = 580nM) without apparent cytotoxicity (up to 100uM and 24h). Exhibits no antagonist activity toward TLR2/TLR6, TLR3, TLR4, TLR7 at 0.5uM and little inhibitory potency against a panel of 10 kinases at 5uM (by <11% inhibition). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??O?. US Biological Life Sciences. | Worldwide |
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